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• W2012058446 abstract "Nitric oxide (NO) is associated with broad-spectrum antimicrobial activity of particular importance in infections caused by intracellular pathogens. An insertion mutation in the metL gene of Salmonella typhimurium conferred specific hypersusceptibility to S-nitrosothiol NO-donor compounds and attenuated virulence of the organism in mice. The metL gene product catalyzes two proximal metabolic steps required for homocysteine biosynthesis. S-Nitrosothiol resistance was restored by exogenous homocysteine or introduction of the metL gene on a plasmid. Measurement of expression of the homocysteine-sensitive metH gene indicated that S-nitrosothiols may directly deplete intracellular homocysteine. Homocysteine may act as an endogenous NO antagonist in diverse processes including infection, atherosclerosis, and neurologic disease." @default.
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• W2012058446 date "1996-04-19" @default.
• W2012058446 modified "2023-09-27" @default.
• W2012058446 title "Homocysteine Antagonism of Nitric Oxide-Related Cytostasis in <b> <i>Salmonella typhimurium</i> </b>" @default.
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• W2012058446 doi "https://doi.org/10.1126/science.272.5260.414" @default.
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