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- W2012059154 abstract "The salient structural features of urotensin II (U II) required for stimulation of its G-protein-coupled receptor were obtained from biological evaluation of synthetic derivatives of U II. This approach led to a plausible U-II–receptor complex (see picture), which inspired the installation of nonnatural amino acids in place of key residues. Notably, replacement of tyrosine with (2-naphthyl)-L-alanine resulted in a sixfold potency improvement compared to U II. Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2002/2002/z18301_s.pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article." @default.
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- W2012059154 date "2002-08-16" @default.
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- W2012059154 title "StructureâFunction Analysis of Urotensin II and Its Use in the Construction of a LigandâReceptor Working Model" @default.
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