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- W2012059575 abstract "Cyclic GMP (guanosine 3′:5′-cyclic monophosphate) accumulation and Ca2+ influx have been correlated with early nuclear events associated with increases in RNA polymerase I activity and decreases in RNA polymerase II activity in phytohemagglutinin-stimulated lymphocytes. In the present study we demonstrate that cyclic GMP in the presence of Ca2+ stimulates RNA polymerase I activity in lymphocyte nuclei isolated from both non-stimulated and phytohemagglutinin-stimulated lymphocytes. In addition, cyclic GMP in the presence of Ca2+ decreases RNA polymerase II activity in both non-stimulated and phytohemagglutinin-stimulated lymphocyte nuclei. These observations suggest that cyclic GMP and Ca2+ may represent components of a plasma membrane-to-nucleus “mitogen signal sequence”." @default.
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- W2012059575 date "1975-10-01" @default.
- W2012059575 modified "2023-09-23" @default.
- W2012059575 title "Cyclic GMP and lymphocyte proliferation: Effects on DNA-dependent RNA polymerase I and II activities" @default.
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- W2012059575 doi "https://doi.org/10.1016/0006-291x(75)90528-8" @default.
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