Matches in SemOpenAlex for { <https://semopenalex.org/work/W2012060810> ?p ?o ?g. }
- W2012060810 endingPage "464" @default.
- W2012060810 startingPage "455" @default.
- W2012060810 abstract "The enhancement of metabolic rate by thyroid hormone in target tissues is accompanied by increased glucose utilization, which in skeletal muscle and many other tissues is regulated at the level of membrane transport. To elucidate the role of thyroid hormone as a regulator of glucose transport in skeletal muscle, we have examined its effects on the expression of the muscle/fat (insulin-regulatable) glucose transporter, a distinct glucose transporter isotype whose expression is limited to insulin-sensitive tissues and which appears to be the major glucose transport protein in skeletal muscle. Treatment of hypothyroid rats with L-T3 (T3; 100 μg/100 g BW-day for 6 days) increased the abundance of the muscle/fat glucose transporter protein in crude membranes from hindlimb muscle, assessed by immunoblotting, to 145 ± 8% of the control value in animals fasted for 17-20 h before death and to 159 ± 16% of the control value in animals fed ad libitum (mean ± SE). In purified plasma membranes, this effect of thyroid hormone was greater (208 ± 23% and 219 ± 13% of control in fasted and fed animals, respectively). Similar increases were found in an intracellular membrane fraction. Levels of muscle/fat glucose transporter mRNA were also increased in hindlimb muscle from the T3-treated rats, to 261 ± 17% and 316 ± 23% of control values in fasted and fed animals, respectively. In contrast, the erythroid glucose transporter protein and its mRNA, which are only weakly expressed in skeletal muscle but strongly expressed in brain, were not substantially increased by T3 treatment in either tissue. In experiments comparing hypothyroid, euthyroid, and chronically T4-treated animals, muscle/fat glucose transporter protein and mRNA abundance in skeletal muscle were also found to be dependent on thyroid status. Thyroid hormone may, thus, be an important regulator of the muscle/fat glucose transporter in skeletal muscle." @default.
- W2012060810 created "2016-06-24" @default.
- W2012060810 creator A5013673575 @default.
- W2012060810 creator A5032119453 @default.
- W2012060810 creator A5034977246 @default.
- W2012060810 date "1991-07-01" @default.
- W2012060810 modified "2023-10-16" @default.
- W2012060810 title "Thyroid Hormone Increases Muscle/Fat Glucose Transporter Gene Expression in Rat Skeletal Muscle*" @default.
- W2012060810 cites W1526300496 @default.
- W2012060810 cites W1537045952 @default.
- W2012060810 cites W1544390571 @default.
- W2012060810 cites W1553733060 @default.
- W2012060810 cites W1565928898 @default.
- W2012060810 cites W1574991890 @default.
- W2012060810 cites W1581503263 @default.
- W2012060810 cites W1606138580 @default.
- W2012060810 cites W1775749144 @default.
- W2012060810 cites W1963840316 @default.
- W2012060810 cites W1971060217 @default.
- W2012060810 cites W1972174293 @default.
- W2012060810 cites W1984950565 @default.
- W2012060810 cites W1996845220 @default.
- W2012060810 cites W1999362971 @default.
- W2012060810 cites W2000977514 @default.
- W2012060810 cites W2022721465 @default.
- W2012060810 cites W2023947174 @default.
- W2012060810 cites W2028627182 @default.
- W2012060810 cites W2030497991 @default.
- W2012060810 cites W2031265390 @default.
- W2012060810 cites W2035198012 @default.
- W2012060810 cites W2038035063 @default.
- W2012060810 cites W2067223472 @default.
- W2012060810 cites W2067307619 @default.
- W2012060810 cites W2070099193 @default.
- W2012060810 cites W2070120544 @default.
- W2012060810 cites W2070892520 @default.
- W2012060810 cites W2072850070 @default.
- W2012060810 cites W2074783201 @default.
- W2012060810 cites W2079752404 @default.
- W2012060810 cites W2087015690 @default.
- W2012060810 cites W2096996169 @default.
- W2012060810 cites W2122953585 @default.
- W2012060810 cites W2134812217 @default.
- W2012060810 cites W2136433521 @default.
- W2012060810 cites W2143122636 @default.
- W2012060810 cites W2144041845 @default.
- W2012060810 cites W2158264015 @default.
- W2012060810 cites W2168808578 @default.
- W2012060810 cites W2169401893 @default.
- W2012060810 cites W2271840264 @default.
- W2012060810 cites W2336842108 @default.
- W2012060810 cites W2413058670 @default.
- W2012060810 doi "https://doi.org/10.1210/endo-129-1-455" @default.
- W2012060810 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2055200" @default.
- W2012060810 hasPublicationYear "1991" @default.
- W2012060810 type Work @default.
- W2012060810 sameAs 2012060810 @default.
- W2012060810 citedByCount "73" @default.
- W2012060810 countsByYear W20120608102012 @default.
- W2012060810 countsByYear W20120608102013 @default.
- W2012060810 countsByYear W20120608102014 @default.
- W2012060810 countsByYear W20120608102016 @default.
- W2012060810 countsByYear W20120608102017 @default.
- W2012060810 countsByYear W20120608102019 @default.
- W2012060810 countsByYear W20120608102020 @default.
- W2012060810 countsByYear W20120608102021 @default.
- W2012060810 countsByYear W20120608102022 @default.
- W2012060810 crossrefType "journal-article" @default.
- W2012060810 hasAuthorship W2012060810A5013673575 @default.
- W2012060810 hasAuthorship W2012060810A5032119453 @default.
- W2012060810 hasAuthorship W2012060810A5034977246 @default.
- W2012060810 hasConcept C126322002 @default.
- W2012060810 hasConcept C134018914 @default.
- W2012060810 hasConcept C161573976 @default.
- W2012060810 hasConcept C2779306644 @default.
- W2012060810 hasConcept C2779959927 @default.
- W2012060810 hasConcept C526584372 @default.
- W2012060810 hasConcept C71315377 @default.
- W2012060810 hasConcept C71924100 @default.
- W2012060810 hasConcept C86803240 @default.
- W2012060810 hasConceptScore W2012060810C126322002 @default.
- W2012060810 hasConceptScore W2012060810C134018914 @default.
- W2012060810 hasConceptScore W2012060810C161573976 @default.
- W2012060810 hasConceptScore W2012060810C2779306644 @default.
- W2012060810 hasConceptScore W2012060810C2779959927 @default.
- W2012060810 hasConceptScore W2012060810C526584372 @default.
- W2012060810 hasConceptScore W2012060810C71315377 @default.
- W2012060810 hasConceptScore W2012060810C71924100 @default.
- W2012060810 hasConceptScore W2012060810C86803240 @default.
- W2012060810 hasIssue "1" @default.
- W2012060810 hasLocation W20120608101 @default.
- W2012060810 hasLocation W20120608102 @default.
- W2012060810 hasOpenAccess W2012060810 @default.
- W2012060810 hasPrimaryLocation W20120608101 @default.
- W2012060810 hasRelatedWork W146700098 @default.
- W2012060810 hasRelatedWork W1981107935 @default.
- W2012060810 hasRelatedWork W2010645160 @default.
- W2012060810 hasRelatedWork W2044897248 @default.