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- W2012065293 abstract "Myogenic differentiation of skeletal myoblasts in culture is triggered by withdrawal of serum mitogens. Expression of one of the serum-inducible, immediate early genes, the protooncogene c-jun, is maintained under low-serum conditions during myogenic differentiation of L6 myoblasts. In this report we have used agents that modulate protein kinases and Ca 2+ levels to investigate how the expression of c-jun and myogenin mRNA and also the activator protein 1 (AP-1) DNA-binding activity are regulated in differentiating L6 cells. Our results show that expression of c-jun and myogenin are regulated independent of each other. Furthermore, down regulation of c-jun expression does not cause an increase in myogenin expression, suggesting that c-jun does not suppress myogenin expression in these cells. Electrophoretic mobility shift and ultraviolet cross-linking analyses revealed that the AP-1 complexes of proliferating myoblasts and differentiating myotubes are formed of similar set of polypeptides, and the AP-1 binding activity is probably modulated by posttranslational modifications in differentiating L6 cells.Key words: myogenin, protein kinase C, cAMP, Ca 2+ , muscle differentiation." @default.
- W2012065293 created "2016-06-24" @default.
- W2012065293 creator A5006901857 @default.
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- W2012065293 date "1993-03-01" @default.
- W2012065293 modified "2023-09-27" @default.
- W2012065293 title "Regulation of <i>c-jun</i>/AP-1 expression in rat L6 myoblasts" @default.
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- W2012065293 doi "https://doi.org/10.1139/o93-031" @default.
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