FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2012065514> ?p ?o ?g. }

• W2012065514 endingPage "931" @default.
• W2012065514 startingPage "921" @default.
• W2012065514 abstract "The contribution of viral infectivity to the expression of MHC class II-restricted T cell determinants was studied. A murine I-Ed-restricted T cell hybridoma recognizing the neuraminidase (NA) glycoprotein of influenza PR8 virus was stimulated strongly by infectious virus but failed to recognize antigen introduced on noninfectious virions. Recognition correlated with the de novo synthesis of viral NA within infected APC. The effectiveness of infectious virus did not depend strictly upon the amount of NA present in cultures, since high NA concentrations could be achieved by addition of nonreplicative virus without being stimulatory for NA-specific T cells. Recognition of a determinant generated only when synthesized in murine host cells was ruled out, since, in high concentration, NA isolated from purified egg-grown virions, even if reduced and alkylated, was recognized by the T hybridoma clone. Isolated NA was recognized when added to pre-fixed APC, suggesting that this form of antigen was able to bypass the usual processing pathway of exogenous proteins. Data suggest that endogenously synthesized antigen may contribute most significantly to presentation of labile T cell determinants. In addition to NA, recognition of an I-Ed-restricted determinant of the influenza hemagglutinin (HA) molecule, shown previously to have a relatively short half-life on APC surfaces, was enhanced greatly by infectious virus. In contrast, T cell recognition of a more stably expressed I-Ed-restricted site of the same HA polypeptide was only marginally improved on infected APC." @default.
• W2012065514 created "2016-06-24" @default.
• W2012065514 creator A5049827370 @default.
• W2012065514 creator A5055438317 @default.
• W2012065514 date "1989-03-01" @default.
• W2012065514 modified "2023-09-26" @default.
• W2012065514 title "Class II major histocompatibility complex-restricted T cells specific for a virion structural protein that do not recognize exogenous influenza virus. Evidence that presentation of labile T cell determinants is favored by endogenous antigen synthesis." @default.
• W2012065514 cites W1160821720 @default.
• W2012065514 cites W1493816460 @default.
• W2012065514 cites W1493865972 @default.
• W2012065514 cites W1496893639 @default.
• W2012065514 cites W1501936064 @default.
• W2012065514 cites W1506157243 @default.
• W2012065514 cites W1513536965 @default.
• W2012065514 cites W1519185370 @default.
• W2012065514 cites W1552210821 @default.
• W2012065514 cites W1563157353 @default.
• W2012065514 cites W1579578038 @default.
• W2012065514 cites W1586964881 @default.
• W2012065514 cites W169743129 @default.
• W2012065514 cites W1919985497 @default.
• W2012065514 cites W1920548561 @default.
• W2012065514 cites W1987668067 @default.
• W2012065514 cites W1992412976 @default.
• W2012065514 cites W2018299840 @default.
• W2012065514 cites W2020850769 @default.
• W2012065514 cites W2037328302 @default.
• W2012065514 cites W2046285013 @default.
• W2012065514 cites W2046609186 @default.
• W2012065514 cites W2063929734 @default.
• W2012065514 cites W2067510436 @default.
• W2012065514 cites W2074360298 @default.
• W2012065514 cites W2080757497 @default.
• W2012065514 cites W2099974869 @default.
• W2012065514 cites W2102113761 @default.
• W2012065514 cites W2105818762 @default.
• W2012065514 cites W2114918609 @default.
• W2012065514 cites W2133658730 @default.
• W2012065514 cites W2146034497 @default.
• W2012065514 cites W2146581768 @default.
• W2012065514 cites W2152280976 @default.
• W2012065514 cites W2171086365 @default.
• W2012065514 doi "https://doi.org/10.1084/jem.169.3.921" @default.
• W2012065514 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2189282" @default.
• W2012065514 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2784481" @default.
• W2012065514 hasPublicationYear "1989" @default.
• W2012065514 type Work @default.
• W2012065514 sameAs 2012065514 @default.
• W2012065514 citedByCount "53" @default.
• W2012065514 countsByYear W20120655142013 @default.
• W2012065514 countsByYear W20120655142014 @default.
• W2012065514 countsByYear W20120655142015 @default.
• W2012065514 countsByYear W20120655142016 @default.
• W2012065514 countsByYear W20120655142017 @default.
• W2012065514 countsByYear W20120655142019 @default.
• W2012065514 countsByYear W20120655142021 @default.
• W2012065514 countsByYear W20120655142022 @default.
• W2012065514 crossrefType "journal-article" @default.
• W2012065514 hasAuthorship W2012065514A5049827370 @default.
• W2012065514 hasAuthorship W2012065514A5055438317 @default.
• W2012065514 hasBestOaLocation W20120655141 @default.
• W2012065514 hasConcept C104317684 @default.
• W2012065514 hasConcept C106358424 @default.
• W2012065514 hasConcept C134164806 @default.
• W2012065514 hasConcept C147483822 @default.
• W2012065514 hasConcept C153911025 @default.
• W2012065514 hasConcept C159047783 @default.
• W2012065514 hasConcept C180915046 @default.
• W2012065514 hasConcept C203014093 @default.
• W2012065514 hasConcept C207936829 @default.
• W2012065514 hasConcept C2522874641 @default.
• W2012065514 hasConcept C2776090121 @default.
• W2012065514 hasConcept C2778692840 @default.
• W2012065514 hasConcept C55493867 @default.
• W2012065514 hasConcept C67662055 @default.
• W2012065514 hasConcept C7842527 @default.
• W2012065514 hasConcept C81089528 @default.
• W2012065514 hasConcept C83464605 @default.
• W2012065514 hasConcept C86803240 @default.
• W2012065514 hasConcept C8891405 @default.
• W2012065514 hasConceptScore W2012065514C104317684 @default.
• W2012065514 hasConceptScore W2012065514C106358424 @default.
• W2012065514 hasConceptScore W2012065514C134164806 @default.
• W2012065514 hasConceptScore W2012065514C147483822 @default.
• W2012065514 hasConceptScore W2012065514C153911025 @default.
• W2012065514 hasConceptScore W2012065514C159047783 @default.
• W2012065514 hasConceptScore W2012065514C180915046 @default.
• W2012065514 hasConceptScore W2012065514C203014093 @default.
• W2012065514 hasConceptScore W2012065514C207936829 @default.
• W2012065514 hasConceptScore W2012065514C2522874641 @default.
• W2012065514 hasConceptScore W2012065514C2776090121 @default.
• W2012065514 hasConceptScore W2012065514C2778692840 @default.
• W2012065514 hasConceptScore W2012065514C55493867 @default.
• W2012065514 hasConceptScore W2012065514C67662055 @default.
• W2012065514 hasConceptScore W2012065514C7842527 @default.
• W2012065514 hasConceptScore W2012065514C81089528 @default.
• W2012065514 hasConceptScore W2012065514C83464605 @default.
• W2012065514 hasConceptScore W2012065514C86803240 @default.

• next