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• W2012066075 abstract "The present investigation concerns the evaluation of the effect of formulation variables on in vitro floating time and the release properties in developing a floating drug delivery system (FDDS) containing a highly water soluble drug metoprolol tartrate (MT) in the presence of a gas generating agent. A 32 full factorial design was employed in formulating the FDDS containing hydroxyl propylmethylcellulose (HPMC K4M) and sodium carboxymethylcellulose (NaCMC) as swellable polymers. Drug-to-polymer ratio and polymer-to-polymer ratio were included as independent variables. The main effect and the interaction terms were quantitatively evaluated by a quadratic model to predict formulations with the floating time desired, and the release properties. It was found that only drug-to-polymer ratio and its quadratic term were found to be significantly affective for all the response variables. Non-Fickian transport was confirmed as a release mechanism from the optimized formulations. The desirability function was used to optimize the response variables, each having a different target, and the observed responses were highly agreed with experimental values. The results demonstrate the feasibility of the model in the development of FDDS containing a highly water-soluble drug MT." @default.
• W2012066075 created "2016-06-24" @default.
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• W2012066075 date "2008-01-01" @default.
• W2012066075 modified "2023-09-27" @default.
• W2012066075 title "The study on the effect of formulation variables on in vitro floating time and the release properties of a floating drug delivery system by a statistical optimization technique" @default.
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• W2012066075 doi "https://doi.org/10.2298/ciceq0801017n" @default.
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