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• W2012066379 abstract "Increases of cytokine in the blood play important roles in the pathogenesis of influenza-associated encephalopathy. TNF-α was administered intravenously to wild-type mice, after which blood, CSF and brain tissue were obtained, and changes in BBB permeability, the amounts of MMP-9 and TIMP-1, and the localization of activated MMP were assessed. There was a significant increase in BBB permeability after 6 and 12 hr. MMP-9 was increased after 3 hr in the brain and cerebrospinal fluid, which was earlier than in the serum. TIMP-1 protein in the brain increased significantly after MMP-9 had increased. Activation of MMP-9 was observed in neurons in the cerebral cortex and hippocampus, and in vascular endothelial cells. These findings suggest that an increase in blood TNF-α promotes activation of MMP-9 in the brain, and may also induce an increase in permeability of the BBB. Early activation of MMP-9 in the brain may contribute to an early onset of neurological disorders and brain edema prior to multiple organ failure in those inflammatory diseases associated with highly increased concentrations of TNF-α in the blood, such as sepsis, burns, trauma and influenza-associated encephalopathy." @default.
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• W2012066379 date "2010-04-01" @default.
• W2012066379 modified "2023-10-18" @default.
• W2012066379 title "Increase of tumor necrosis factor-α in the blood induces the early activation of matrix metalloproteinase-9 in the brain" @default.
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• W2012066379 doi "https://doi.org/10.1111/j.1348-0421.2010.00226.x" @default.
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