FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2012066823> ?p ?o ?g. }

• W2012066823 endingPage "510" @default.
• W2012066823 startingPage "503" @default.
• W2012066823 abstract "Background: Gastrin stimulates histidine decarboxylase (HDC) activity and proliferation of enterochromaffin-like (ECL) cells. Furthermore, it has been suggested that gastrin controls HDC gene expression. We therefore analysed the effect of gastrin receptor blockade by PD 136 450 (CAM 1189) on HDC gene expression. The influence of PD 136 450 on gastrin, somatostatin, and chromogranin A was also evaluated. Methods: Gene expression of HDC, gastrin, somatostatin, and chromogranin A (CgA) was analysed by Northern blot analyses after 14 days' application of the proton pump inhibitor BY 308 and/or the gastrin/cholecystokinin B receptor antagonist PD 136 450. Results: PD 136 450 had no significant effect on gastrin mRNA or somatostatin mRNA in controls and during proton pump inhibition. BY 308 treatment resulted in a marked induction of HDC and CgA mRNA, whereas concomitant PD 136 450 in a concentration previously shown to suppress maximal pentagastrin-induced gastric acid secretion and to prevent BY 308-induced ECL cell proliferation did not result in significant alteration. PD 136 450 increased HDC significantly and CgA mRNA to a lesser extent in normogastrinaemic rats, whereas previous work showed a decreased ECL cell labelling index. Conclusions: These data suggest that there are independent regulatory pathways for ECL cell proliferation and gene expression. Other factors besides gastrin may act through PD 136 450-insensitive pathways to control HDC and CgA gene expression." @default.
• W2012066823 created "2016-06-24" @default.
• W2012066823 creator A5009440733 @default.
• W2012066823 creator A5015185039 @default.
• W2012066823 creator A5018028476 @default.
• W2012066823 creator A5044542565 @default.
• W2012066823 creator A5057290988 @default.
• W2012066823 date "1995-01-01" @default.
• W2012066823 modified "2023-10-01" @default.
• W2012066823 title "Effect of Gastrin Receptor Blockade on Gastrin and Histidine Decarboxylase Gene Expression in Rats during Achlorhydria" @default.
• W2012066823 cites W1562288220 @default.
• W2012066823 cites W1675520567 @default.
• W2012066823 cites W1707863440 @default.
• W2012066823 cites W1958401509 @default.
• W2012066823 cites W1968353005 @default.
• W2012066823 cites W1970203013 @default.
• W2012066823 cites W1971325596 @default.
• W2012066823 cites W1977133915 @default.
• W2012066823 cites W1983493986 @default.
• W2012066823 cites W1986718205 @default.
• W2012066823 cites W1987182268 @default.
• W2012066823 cites W1990612432 @default.
• W2012066823 cites W2009289013 @default.
• W2012066823 cites W2013538870 @default.
• W2012066823 cites W2027119507 @default.
• W2012066823 cites W2047433578 @default.
• W2012066823 cites W2051680485 @default.
• W2012066823 cites W2053126072 @default.
• W2012066823 cites W2057562235 @default.
• W2012066823 cites W2065981508 @default.
• W2012066823 cites W2068917080 @default.
• W2012066823 cites W2069919719 @default.
• W2012066823 cites W2071881271 @default.
• W2012066823 cites W2086708288 @default.
• W2012066823 cites W2092509370 @default.
• W2012066823 cites W2094020906 @default.
• W2012066823 cites W2159870483 @default.
• W2012066823 cites W2396947151 @default.
• W2012066823 cites W2886800621 @default.
• W2012066823 cites W2950105308 @default.
• W2012066823 doi "https://doi.org/10.3109/00365529509089780" @default.
• W2012066823 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7569754" @default.
• W2012066823 hasPublicationYear "1995" @default.
• W2012066823 type Work @default.
• W2012066823 sameAs 2012066823 @default.
• W2012066823 citedByCount "7" @default.
• W2012066823 countsByYear W20120668232023 @default.
• W2012066823 crossrefType "journal-article" @default.
• W2012066823 hasAuthorship W2012066823A5009440733 @default.
• W2012066823 hasAuthorship W2012066823A5015185039 @default.
• W2012066823 hasAuthorship W2012066823A5018028476 @default.
• W2012066823 hasAuthorship W2012066823A5044542565 @default.
• W2012066823 hasAuthorship W2012066823A5057290988 @default.
• W2012066823 hasConcept C104317684 @default.
• W2012066823 hasConcept C107539642 @default.
• W2012066823 hasConcept C126322002 @default.
• W2012066823 hasConcept C128240485 @default.
• W2012066823 hasConcept C134018914 @default.
• W2012066823 hasConcept C150194340 @default.
• W2012066823 hasConcept C170493617 @default.
• W2012066823 hasConcept C177707886 @default.
• W2012066823 hasConcept C181199279 @default.
• W2012066823 hasConcept C185592680 @default.
• W2012066823 hasConcept C186199130 @default.
• W2012066823 hasConcept C192233252 @default.
• W2012066823 hasConcept C204232928 @default.
• W2012066823 hasConcept C2776297358 @default.
• W2012066823 hasConcept C2776986829 @default.
• W2012066823 hasConcept C2777593968 @default.
• W2012066823 hasConcept C2778460671 @default.
• W2012066823 hasConcept C49039625 @default.
• W2012066823 hasConcept C55493867 @default.
• W2012066823 hasConcept C71924100 @default.
• W2012066823 hasConcept C77231918 @default.
• W2012066823 hasConcept C86803240 @default.
• W2012066823 hasConceptScore W2012066823C104317684 @default.
• W2012066823 hasConceptScore W2012066823C107539642 @default.
• W2012066823 hasConceptScore W2012066823C126322002 @default.
• W2012066823 hasConceptScore W2012066823C128240485 @default.
• W2012066823 hasConceptScore W2012066823C134018914 @default.
• W2012066823 hasConceptScore W2012066823C150194340 @default.
• W2012066823 hasConceptScore W2012066823C170493617 @default.
• W2012066823 hasConceptScore W2012066823C177707886 @default.
• W2012066823 hasConceptScore W2012066823C181199279 @default.
• W2012066823 hasConceptScore W2012066823C185592680 @default.
• W2012066823 hasConceptScore W2012066823C186199130 @default.
• W2012066823 hasConceptScore W2012066823C192233252 @default.
• W2012066823 hasConceptScore W2012066823C204232928 @default.
• W2012066823 hasConceptScore W2012066823C2776297358 @default.
• W2012066823 hasConceptScore W2012066823C2776986829 @default.
• W2012066823 hasConceptScore W2012066823C2777593968 @default.
• W2012066823 hasConceptScore W2012066823C2778460671 @default.
• W2012066823 hasConceptScore W2012066823C49039625 @default.
• W2012066823 hasConceptScore W2012066823C55493867 @default.
• W2012066823 hasConceptScore W2012066823C71924100 @default.
• W2012066823 hasConceptScore W2012066823C77231918 @default.
• W2012066823 hasConceptScore W2012066823C86803240 @default.
• W2012066823 hasIssue "6" @default.

• next