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- W2012067886 abstract "Dramatic reorganization of dendrites and axonal terminals is a hallmark of neuronal remodeling during metamorphosis in the hawkmoth, Manduca sexta. The dendritic and axonal arbors of leg motor neurons regress in late larval stages, then regrow during adult development. Ecdysteroids, the insect steroids that trigger metamorphosis, control both regression and outgrowth in vivo and stimulate neuritic growth in cultured pupal leg motor neurons. To identify subcellular targets of ecdysteroid action in these neurons, we examined the dynamic and structural features of branching and their modulation by ecdysteroids in vitro. Delayed treatment of pupal leg motor neurons with ecdysteroid led to a robust enhancement of neuritic branch accumulation accompanied by a subtle effect on total neuritic length. Repeated imaging revealed that branch formation occurred almost exclusively at the growth cone; interstitial branching was extremely rare. Ecdysteroid treatment significantly enhanced both the formation and retention of branches at the growth cone. Branches formed via two distinct processes: engorgement (of fine protrusions) and condensation (of lamellae) with the relative contributions of these mechanisms being unaltered by ecdysteroid. Confocal imaging of the cytoskeleton demonstrated that growth cones consisted of microtubule-based domains fringed by actin-based filopodia. Treated growth cones were larger and displayed increased numbers of microtubule-based branches, whereas filopodial density was unaffected. These findings indicate that ecdysteroid enhances neuritic branching by altering growth cone structure and function, and suggest that hormonal modulation of cytoskeletal interactions contributes significantly to neuritic remodeling during metamorphosis. © 1999 John Wiley & Sons, Inc. J Neurobiol 38: 27–45, 1999" @default.
- W2012067886 created "2016-06-24" @default.
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- W2012067886 date "1999-01-01" @default.
- W2012067886 modified "2023-10-11" @default.
- W2012067886 title "Steroid hormone enhancement of neurite outgrowth in identified insect motor neurons involves specific effects on growth cone form and function" @default.
- W2012067886 cites W1490295223 @default.
- W2012067886 cites W1500609492 @default.
- W2012067886 cites W1521404049 @default.
- W2012067886 cites W1526145742 @default.
- W2012067886 cites W1585284682 @default.
- W2012067886 cites W1586509210 @default.
- W2012067886 cites W1586523812 @default.
- W2012067886 cites W1598711912 @default.
- W2012067886 cites W1618300553 @default.
- W2012067886 cites W1639119719 @default.
- W2012067886 cites W1849369087 @default.
- W2012067886 cites W1873041227 @default.
- W2012067886 cites W1883988145 @default.
- W2012067886 cites W1895213472 @default.
- W2012067886 cites W1895749396 @default.
- W2012067886 cites W1916483082 @default.
- W2012067886 cites W1919066930 @default.
- W2012067886 cites W1932215687 @default.
- W2012067886 cites W1953807893 @default.
- W2012067886 cites W1963551424 @default.
- W2012067886 cites W1969563780 @default.
- W2012067886 cites W1971125966 @default.
- W2012067886 cites W1971215062 @default.
- W2012067886 cites W1971771942 @default.
- W2012067886 cites W1973512372 @default.
- W2012067886 cites W1974698766 @default.
- W2012067886 cites W1980617751 @default.
- W2012067886 cites W1981816303 @default.
- W2012067886 cites W1984716242 @default.
- W2012067886 cites W1986171966 @default.
- W2012067886 cites W1995305819 @default.
- W2012067886 cites W1999598254 @default.
- W2012067886 cites W1999833864 @default.
- W2012067886 cites W2000303735 @default.
- W2012067886 cites W2002787842 @default.
- W2012067886 cites W2003084435 @default.
- W2012067886 cites W2004832777 @default.
- W2012067886 cites W2005971191 @default.
- W2012067886 cites W2006268333 @default.
- W2012067886 cites W2013436716 @default.
- W2012067886 cites W2015171213 @default.
- W2012067886 cites W2016529329 @default.
- W2012067886 cites W2018752391 @default.
- W2012067886 cites W2022710910 @default.
- W2012067886 cites W2028067698 @default.
- W2012067886 cites W2032722811 @default.
- W2012067886 cites W2035339007 @default.
- W2012067886 cites W2045859688 @default.
- W2012067886 cites W2046264159 @default.
- W2012067886 cites W2049269457 @default.
- W2012067886 cites W2053216099 @default.
- W2012067886 cites W2054093997 @default.
- W2012067886 cites W2057361706 @default.
- W2012067886 cites W2057864153 @default.
- W2012067886 cites W2063963676 @default.
- W2012067886 cites W2067549660 @default.
- W2012067886 cites W2073368157 @default.
- W2012067886 cites W2073784494 @default.
- W2012067886 cites W2076403326 @default.
- W2012067886 cites W2076848103 @default.
- W2012067886 cites W2089558675 @default.
- W2012067886 cites W2105416994 @default.
- W2012067886 cites W2110887671 @default.
- W2012067886 cites W2111516838 @default.
- W2012067886 cites W2119644933 @default.
- W2012067886 cites W2122694225 @default.
- W2012067886 cites W2123847061 @default.
- W2012067886 cites W2125451577 @default.
- W2012067886 cites W2131832714 @default.
- W2012067886 cites W2152110038 @default.
- W2012067886 cites W2153162541 @default.
- W2012067886 cites W2154771454 @default.
- W2012067886 cites W2156904908 @default.
- W2012067886 cites W2161001592 @default.
- W2012067886 cites W2161592001 @default.
- W2012067886 cites W2167442881 @default.
- W2012067886 cites W2167816663 @default.
- W2012067886 cites W2171960232 @default.
- W2012067886 cites W2182661714 @default.
- W2012067886 cites W4293154522 @default.
- W2012067886 doi "https://doi.org/10.1002/(sici)1097-4695(199901)38:1<27::aid-neu3>3.0.co;2-u" @default.
- W2012067886 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10027561" @default.
- W2012067886 hasPublicationYear "1999" @default.
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