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• W2012069250 abstract "Antiplatelet drugs are a cornerstone of tretment in patients with acute coronary syndromes leading to significant reduction of recurrent ischemic events [ [1] Patrono C. Bachmann F. Baigent C. Bode C. De Caterina R. Charbonnier B. et al. European Society of Cardiology. Expert consensus document on the use of antiplatelet agents. The task force on the use of antiplatelet agents in patients with atherosclerotic cardiovascular disease of the European society of cardiology. Eur Heart J. 2004; 25: 166-181 Crossref PubMed Scopus (388) Google Scholar ]. Benefits of antiplatelet therapy may be limited by increased frequency of bleeding incidents [ [1] Patrono C. Bachmann F. Baigent C. Bode C. De Caterina R. Charbonnier B. et al. European Society of Cardiology. Expert consensus document on the use of antiplatelet agents. The task force on the use of antiplatelet agents in patients with atherosclerotic cardiovascular disease of the European society of cardiology. Eur Heart J. 2004; 25: 166-181 Crossref PubMed Scopus (388) Google Scholar ]. Renal impairment has been established as one of the major risk factors of bleeding in ACS mainly as a cause of coexisting patelet dysfunction [ 2 Moscucci M. Fox K.A. Cannon C.P. Klein W. López-Sendón J. Montalescot G. et al. Predictors of major bleeding in acute coronary syndromes: the Global Registry of Acute Coronary Events (GRACE). Eur Heart J. 2003; 24: 1815-1823 Crossref PubMed Scopus (792) Google Scholar , 3 Attallah N. Yassine L. Fisher K. Yee J. Risk of bleeding and restenosis among chronic kidney disease patients undergoing percutaneous coronary intervention. Clin Nephrol. 2005; 64: 412-418 Crossref PubMed Google Scholar ]. Commonly used antiplatelet drugs in ACS such as aspirin, clopidogrel or abciximab are not undergoing renal elimination and therefore are believed to have a safe profile in renal dysfunction [ [4] Task Force for Diagnosis and Treatment of Non-ST-Segment Elevation Acute Coronary Syndromes of European Society of Cardiology Bassand J.P. Hamm C.W. Ardissino D. Boersma E. Budaj A. et al. Guidelines for the diagnosis and treatment of non-ST-segment elevation acute coronary syndromes. Eur Heart J. 2007; 28: 1598-1660 Crossref PubMed Scopus (1) Google Scholar ]. However, deminished platelet function in renal impairment may be related to lower platelet reactivity in patients with ACS and renal dysfunction in comparison to patients with ACS and normal renal function [ 5 Sohal A.S. Gangji A.S. Crowther M.A. Treleaven D. Uremic bleeding: pathophysiology and clinical risk factors. Thromb Res. 2006; 118: 417-422 Abstract Full Text Full Text PDF PubMed Scopus (119) Google Scholar , 6 Noris M. Benigni A. Boccardo P. Gotti E. Benfenati E. Aiello S. et al. Enhanced nitric oxide synthesis in uremia: implications for platelet dysfunction and dialysis hypotension. Kidney Int. 1993; 44: 445-450 Crossref PubMed Scopus (211) Google Scholar , 7 Noris M. Remuzzi G. Uremic bleeding: closing the circle after 30 years of controversies?. Blood. 1999; 94: 2569-2574 PubMed Google Scholar ]. Confirmation of the above hypothesis would improve our understanding of the potential mechanism behind increased tendency for bleeding in patients with ACS and renal dysfunction. Therefore, the aim of the study was to analyze platelet reactivity in relation to renal function in patients with ACS treated with dual (aspirin and clopidogrel) or triple (aspirin, clopidogrel and abciximab) antiplatelet therapy." @default.
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• W2012069250 date "2010-01-01" @default.
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• W2012069250 title "Platelet reactivity on aspirin, clopidogrel and abciximab in patients with acute coronary syndromes and reduced estimated glomerular filtration rate" @default.
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• W2012069250 doi "https://doi.org/10.1016/j.thromres.2009.03.015" @default.
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