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• W2012072488 abstract "Normal pregnancy is characterized by attenuated vascular reactivity to a variety of contractile agonists and this, in part, has been attributed to increased circulating vasodilators and/or impaired Ca2+-influx through L-type Ca2+-channels. Our hypothesis in this study was that reduced Ca2+-dependent (influx) and Ca2+-independent (involving the RhoA/Rho-kinase pathway) mechanisms contributed to attenuated vasopressin-induced contraction of the pregnant rat aorta. AVP (10− 10 − 3 × 10− 7 M) induced concentration-dependent contraction of aortic ring segments from nonpregnant and pregnant rats with no significant change in pD2 values (8.53 ± 0.11 and 8.33 ± 0.18 in nonpregnant and pregnant rats, respectively). The maximum response was however significantly reduced in aorta segments from pregnant rats. Nifedipine (10− 6 M) significantly inhibited AVP-induced contraction in artery segments from nonpregnant but not pregnant rats indicating a reduced role for Ca2+-influx through L-type Ca2+-channels in AVP-induced contractions of the pregnant rat aorta. Western blot analysis revealed the expression of ROCK-1 and ROCK-II isoforms in aorta segments from both groups. There was a significant reduction in the expression of ROCK-1 and ROCK-II isoforms in aortic tissues from pregnant rats. This is consistent with the reduced potency of Y-27632 in inhibiting AVP (10− 7 M) induced contraction in aorta segments from pregnant rats. It was concluded that pregnancy-induced attenuated vascular response to AVP was due to decreased Ca2+-influx through L-type Ca2+-channels and decreased sensitization of the contractile myofilaments to Ca2+." @default.
• W2012072488 created "2016-06-24" @default.
• W2012072488 creator A5036834833 @default.
• W2012072488 creator A5051831713 @default.
• W2012072488 creator A5063454369 @default.
• W2012072488 date "2006-03-01" @default.
• W2012072488 modified "2023-09-27" @default.
• W2012072488 title "Pregnancy-induced modulation of calcium mobilization and down-regulation of Rho-kinase expression contribute to attenuated vasopressin-induced contraction of the rat aorta" @default.
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• W2012072488 doi "https://doi.org/10.1016/j.vph.2005.11.003" @default.
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