Matches in SemOpenAlex for { <https://semopenalex.org/work/W2012073343> ?p ?o ?g. }
- W2012073343 endingPage "42" @default.
- W2012073343 startingPage "36" @default.
- W2012073343 abstract "Transmissible gastroenteritis virus (TGEV) is identified as one of the most important pathogenic agents during swine enteric infection, leading to high mortality in neonatal pigs and severe annual economic loss in swine-producing areas. Up to date, various vaccines developed against TGEV still need to be improved. To exploit the possibility of using RNA interference (RNAi) as a strategy against TGEV infection, two shRNA-expressing plasmids (pEGFP-U6/P1 and pEGFP-U6/P2) targeting the RNA-dependent RNA polymerase (RdRp) gene of TGEV were constructed and transfected into swine testicular (ST) cells. The cytopathic effect (CPE) and MTS assays demonstrated that both shRNAs were capable of protecting cells against TGEV invasion with very high specificity and efficiency. A real-time quantitative RT-PCR further confirmed that the amounts of viral RNAs in cell cultures pre-transfected with the two plasmids were reduced by 95.2% and up to 100%, respectively. Our results suggest that RNAi might be a promising new strategy against TGEV infection." @default.
- W2012073343 created "2016-06-24" @default.
- W2012073343 creator A5005743292 @default.
- W2012073343 creator A5012142437 @default.
- W2012073343 creator A5053248971 @default.
- W2012073343 creator A5057046498 @default.
- W2012073343 creator A5057741217 @default.
- W2012073343 creator A5068183875 @default.
- W2012073343 creator A5077374383 @default.
- W2012073343 creator A5083163638 @default.
- W2012073343 date "2007-04-01" @default.
- W2012073343 modified "2023-09-27" @default.
- W2012073343 title "Effective inhibition of porcine transmissible gastroenteritis virus replication in ST cells by shRNAs targeting RNA-dependent RNA polymerase gene" @default.
- W2012073343 cites W1611419331 @default.
- W2012073343 cites W1647075334 @default.
- W2012073343 cites W1649334496 @default.
- W2012073343 cites W1811783050 @default.
- W2012073343 cites W1966326748 @default.
- W2012073343 cites W1969681834 @default.
- W2012073343 cites W1971290134 @default.
- W2012073343 cites W1975692925 @default.
- W2012073343 cites W1977354935 @default.
- W2012073343 cites W1989407131 @default.
- W2012073343 cites W2006231275 @default.
- W2012073343 cites W2009344644 @default.
- W2012073343 cites W2018663057 @default.
- W2012073343 cites W2019431237 @default.
- W2012073343 cites W2026431947 @default.
- W2012073343 cites W2034831897 @default.
- W2012073343 cites W2040930600 @default.
- W2012073343 cites W2042641363 @default.
- W2012073343 cites W2047082074 @default.
- W2012073343 cites W2051649294 @default.
- W2012073343 cites W2060046341 @default.
- W2012073343 cites W2060889706 @default.
- W2012073343 cites W2065343056 @default.
- W2012073343 cites W2069242612 @default.
- W2012073343 cites W2071139337 @default.
- W2012073343 cites W2072040665 @default.
- W2012073343 cites W2086765669 @default.
- W2012073343 cites W2100160011 @default.
- W2012073343 cites W2106367530 @default.
- W2012073343 cites W2107277218 @default.
- W2012073343 cites W2111403591 @default.
- W2012073343 cites W2112480575 @default.
- W2012073343 cites W2113657260 @default.
- W2012073343 cites W2124640087 @default.
- W2012073343 cites W2132536108 @default.
- W2012073343 cites W2135629385 @default.
- W2012073343 cites W2136061223 @default.
- W2012073343 cites W2140043368 @default.
- W2012073343 cites W2144510218 @default.
- W2012073343 cites W2153902498 @default.
- W2012073343 cites W2162220606 @default.
- W2012073343 cites W2163501419 @default.
- W2012073343 cites W2165586566 @default.
- W2012073343 cites W231935617 @default.
- W2012073343 cites W2412503090 @default.
- W2012073343 cites W2518724052 @default.
- W2012073343 cites W82101445 @default.
- W2012073343 doi "https://doi.org/10.1016/j.antiviral.2006.12.007" @default.
- W2012073343 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7114347" @default.
- W2012073343 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17287033" @default.
- W2012073343 hasPublicationYear "2007" @default.
- W2012073343 type Work @default.
- W2012073343 sameAs 2012073343 @default.
- W2012073343 citedByCount "19" @default.
- W2012073343 countsByYear W20120733432012 @default.
- W2012073343 countsByYear W20120733432014 @default.
- W2012073343 countsByYear W20120733432015 @default.
- W2012073343 countsByYear W20120733432016 @default.
- W2012073343 countsByYear W20120733432019 @default.
- W2012073343 countsByYear W20120733432021 @default.
- W2012073343 countsByYear W20120733432022 @default.
- W2012073343 countsByYear W20120733432023 @default.
- W2012073343 crossrefType "journal-article" @default.
- W2012073343 hasAuthorship W2012073343A5005743292 @default.
- W2012073343 hasAuthorship W2012073343A5012142437 @default.
- W2012073343 hasAuthorship W2012073343A5053248971 @default.
- W2012073343 hasAuthorship W2012073343A5057046498 @default.
- W2012073343 hasAuthorship W2012073343A5057741217 @default.
- W2012073343 hasAuthorship W2012073343A5068183875 @default.
- W2012073343 hasAuthorship W2012073343A5077374383 @default.
- W2012073343 hasAuthorship W2012073343A5083163638 @default.
- W2012073343 hasBestOaLocation W20120733431 @default.
- W2012073343 hasConcept C104317684 @default.
- W2012073343 hasConcept C159047783 @default.
- W2012073343 hasConcept C166703698 @default.
- W2012073343 hasConcept C190232843 @default.
- W2012073343 hasConcept C22615655 @default.
- W2012073343 hasConcept C22744801 @default.
- W2012073343 hasConcept C2522874641 @default.
- W2012073343 hasConcept C2775996393 @default.
- W2012073343 hasConcept C2776449523 @default.
- W2012073343 hasConcept C54009773 @default.
- W2012073343 hasConcept C54355233 @default.
- W2012073343 hasConcept C67705224 @default.
- W2012073343 hasConcept C70916841 @default.