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• W2012076064 abstract "The objective of this study was to determine the effect of cleavage stage embryo quality on clinical outcomes for patients with poor blastocyst development on the day of embryo transfer. Review of data retrospectively collected over a period of 5 years. Patients with poor blastocyst development were divided into two treatment (Trt) groups based on the quality of the cleavage stage embryos the blastocysts developed from. Trt 1) Derived from high quality cleavage embryos. Trt 2) Derived from low quality cleavage embryos. Severe male factor patients and donor oocytes were excluded. Patients ≤37 years old (n=101) undergoing IVF with poor blastocyst development on the day of embryo transfer were used in this study. Embryos were cultured in sequential media under 6% CO2, 5% O2 and 89% Nitrogen. Cleavage embryos were classified as of high or low quality based on the number of blastomeres, cell symmetry and percentage of fragmentation. Clinical end points and laboratory parameters were analyzed using Fisher's exact test and t-test as appropriate. There was a higher implantation and clinical pregnancy rate after transferring poor quality blastocysts when they were derived from high quality as compared to low quality cleavage stage embryos. The biochemical pregnancy rate was higher when transferring poor quality blastocysts produced from low quality day 3 embryos. No difference was noted between treatment groups for number of oocytes retrieved, number of embryos transferred and patient age.Tabled 1Clinical outcomes for patients transferring poor quality blastocystsTrtnBiochemical Pregnancy (%)Implantation Rate (%)Clinical Pregnancy (%)1461 (2)aDifferent superscripts within columns indicate significant differences (P<0.05).34 (35)aDifferent superscripts within columns indicate significant differences (P<0.05).27 (59)aDifferent superscripts within columns indicate significant differences (P<0.05).2558 (15)bDifferent superscripts within columns indicate significant differences (P<0.05).21 (19)bDifferent superscripts within columns indicate significant differences (P<0.05).20 (36)bDifferent superscripts within columns indicate significant differences (P<0.05).a,b Different superscripts within columns indicate significant differences (P<0.05). Open table in a new tab Patients with poor blastocyst quality on the day of embryo transfer have superior clinical outcomes when the blastocysts are derived from high quality as compared to low quality day 3 embryos." @default.
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• W2012076064 date "2013-09-01" @default.
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• W2012076064 title "Cleavage stage embryo quality: a good prgnostic indicator for patients with poor quality blastocysts on the day of embryo transfer" @default.
• W2012076064 doi "https://doi.org/10.1016/j.fertnstert.2013.07.304" @default.
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