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- W2012076703 abstract "The cataclysmic disease that develops in mice and humans lacking CD4+ T cells expressing the transcription factor Foxp3 has provided abundant evidence that Foxp3+CD4+ Tregs are required to suppress a latent autoreactivity of the immune system. There is also evidence for the existence of tissue-specific Tregs that can act to suppress regional autoimmune responses, suggesting that Tregs exert their effects, in part, through responding to self-peptides. However, how the immune system generates a repertoire of Tregs that is designed to recognize and direct regulatory function to self-peptides is incompletely understood. This review describes studies aimed at determining how T cell recognition of self-peptide(s) directs Treg formation in the thymus, including discussion of a modified avidity model of thymocyte development. Studies aimed at determining how TCR specificity contributes to the ability of Tregs to suppress autoimmune diseases are also discussed." @default.
- W2012076703 created "2016-06-24" @default.
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- W2012076703 date "2010-05-21" @default.
- W2012076703 modified "2023-10-12" @default.
- W2012076703 title "How specificity for self-peptides shapes the development and function of regulatory T cells" @default.
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- W2012076703 doi "https://doi.org/10.1189/jlb.0310183" @default.
- W2012076703 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2996893" @default.
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