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• W2012077235 abstract "Recent studies suggest that because of their energy value, sugars are more rewarding than non-caloric sweeteners. However, intragastric infusion data indicate that sugars differ in their postoral appetite-stimulating effects. We therefore compared the preference for isocaloric 8% sucrose, glucose, and fructose solutions with that of a non-caloric sweetener solution (0.8% sucralose) in C57BL/6J mice. Brief 2-bottle tests indicated that sucralose was isopreferred to sucrose but more preferred than glucose or fructose. Yet, in long-term tests, the mice preferred sucrose and glucose, but not fructose to sucralose. Additional experiments were conducted with a non-caloric 0.1% sucralose + 0.1% saccharin mixture (S + S), which does not have the postoral inhibitory effects of 0.8% sucralose. The S + S was preferred to fructose in brief and long-term choice tests. S + S was also preferred to glucose and sucrose in brief tests, but the sugars were preferred in long-term tests. In progressive ratio tests, non-deprived and food-deprived mice licked more for glucose but not fructose than for S + S. These findings demonstrate that the nutrient-specific postoral actions, not calories per se, determine the avidity for sugar versus non-caloric sweeteners. Furthermore, sweet taste intensity and potential postoral inhibitory actions must be considered in comparing non-caloric and caloric sweeteners." @default.
• W2012077235 created "2016-06-24" @default.
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• W2012077235 date "2015-02-24" @default.
• W2012077235 modified "2023-10-13" @default.
• W2012077235 title "Postoral Glucose Sensing, Not Caloric Content, Determines Sugar Reward in C57BL/6J Mice" @default.
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• W2012077235 doi "https://doi.org/10.1093/chemse/bjv002" @default.
• W2012077235 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4398051" @default.
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