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- W2012077451 endingPage "1222" @default.
- W2012077451 startingPage "1192" @default.
- W2012077451 abstract "ABSTRACT Numerous molecular, cellular, and physiological biomarkers have been used to assess the responses of marine animals to petroleum compounds. To be used in ecological risk assessment after an oil spill, a biomarker response needs to be linked to petroleum exposure and not strongly influenced by internal and external confounding factors. Biomarker responses to petroleum PAH, dominated by alklated two-and three-ringed aromatics, can be quite different than responses to pyrogenic PAH, dominated by four-and five-ringed aromatics. In many field sites there is a mixture of petrogenic and pyrogenic PAH, along with other contaminants, making it difficult to relate biomarker responses to a particular contaminant class. Biomarkers used to assess marine animal responses in the field include the cytochrome P450 system, heat stress protein, histopathology, and bile fluorescent compounds (FAC). Other biomarkers, including DNA/chromosomal damage and phase 2 enzymes, have been shown to respond after laboratory exposure, but more work needs to be done to demonstrate their usefulness in the field. One of the most useful biomarkers of petroleum exposure are the FAC responses in fish, which can be used to distinguish between petrogenic and pyrogenic PAH exposure. Few of the presently used biomarkers are linked to higher order biological effects, e.g. toxicity, reproductive failure." @default.
- W2012077451 created "2016-06-24" @default.
- W2012077451 creator A5028793996 @default.
- W2012077451 creator A5087894358 @default.
- W2012077451 date "2006-12-01" @default.
- W2012077451 modified "2023-10-11" @default.
- W2012077451 title "Use of Biomarkers in Oil Spill Risk Assessment in the Marine Environment" @default.
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