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• W2012078396 endingPage "1170" @default.
• W2012078396 startingPage "1156" @default.
• W2012078396 abstract "Spinal interneurons modulating motor output are highly diverse but surprisingly arise from just a few embryonic subgroups. The principles governing their development, diversification, and integration into spinal circuits are unknown. This study focuses on the differentiation of adult Renshaw cells (RCs) and Ia inhibitory interneurons (IaINs), two subclasses that respectively mediate recurrent and reciprocal inhibition of motoneurons from embryonic V1 interneurons (V1-INs). V1-INs originate from p1 progenitors and, after they become postmitotic, specifically express the transcription factor engrailed-1, a property that permits genetic labeling of V1 lineages from embryo to adult. RCs and IaINs are V1 derived, but differ in morphology, location, calcium-binding protein expression, synaptic connectivity, and function. These differences are already present in neonates, and in this study we show that their differentiation starts in the early embryo. Using 5'-bromodeoxyuridine birth dating we established that mouse V1-INs can be divided into early (E9.5-E10.5) and late (E11.5-E12.5) groups generated from the p1 domain (where E is embryonic day). The early group upregulates calbindin expression soon after becoming postmitotic and includes RCs, which express the transcription factor MafB during early differentiation and maintain calbindin expression throughout life. The late group includes IaINs, are calbindin-negative, and express FoxP2 at the start of differentiation. Moreover, developing RCs follow a characteristic circumferential migratory route that places them in unique relationship with motor axons with whom they later synaptically interact. We conclude that the fate of these V1-IN subclasses is determined before synaptogenesis and circuit formation by a process that includes differences in neurogenesis time, transcription factor expression, and migratory pathways." @default.
• W2012078396 created "2016-06-24" @default.
• W2012078396 creator A5003096476 @default.
• W2012078396 creator A5066778151 @default.
• W2012078396 date "2012-01-25" @default.
• W2012078396 modified "2023-10-14" @default.
• W2012078396 title "Renshaw Cells and Ia Inhibitory Interneurons Are Generated at Different Times from p1 Progenitors and Differentiate Shortly after Exiting the Cell Cycle" @default.
• W2012078396 cites W1503727145 @default.
• W2012078396 cites W1504807885 @default.
• W2012078396 cites W1551890621 @default.
• W2012078396 cites W1718768577 @default.
• W2012078396 cites W1768274470 @default.
• W2012078396 cites W1802122538 @default.
• W2012078396 cites W1916997466 @default.
• W2012078396 cites W1941953147 @default.
• W2012078396 cites W1964689269 @default.
• W2012078396 cites W1969855284 @default.
• W2012078396 cites W1970957503 @default.
• W2012078396 cites W1971341839 @default.
• W2012078396 cites W1971626524 @default.
• W2012078396 cites W1974176378 @default.
• W2012078396 cites W1974706154 @default.
• W2012078396 cites W1980143518 @default.
• W2012078396 cites W1980242909 @default.
• W2012078396 cites W1983983875 @default.
• W2012078396 cites W1993836210 @default.
• W2012078396 cites W1994371461 @default.
• W2012078396 cites W2002015872 @default.
• W2012078396 cites W2006047257 @default.
• W2012078396 cites W2009697267 @default.
• W2012078396 cites W2014104667 @default.
• W2012078396 cites W2019264546 @default.
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• W2012078396 cites W2028304339 @default.
• W2012078396 cites W2029524468 @default.
• W2012078396 cites W2030150624 @default.
• W2012078396 cites W2032857446 @default.
• W2012078396 cites W2035204110 @default.
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• W2012078396 cites W2042252670 @default.
• W2012078396 cites W2045367058 @default.
• W2012078396 cites W2047378045 @default.
• W2012078396 cites W2051409024 @default.
• W2012078396 cites W2055353932 @default.
• W2012078396 cites W2066556283 @default.
• W2012078396 cites W2067627391 @default.
• W2012078396 cites W2069362985 @default.
• W2012078396 cites W2073929966 @default.
• W2012078396 cites W2075444384 @default.
• W2012078396 cites W2076432328 @default.
• W2012078396 cites W2078415923 @default.
• W2012078396 cites W2079344476 @default.
• W2012078396 cites W2081235375 @default.
• W2012078396 cites W2089722831 @default.
• W2012078396 cites W2092633485 @default.
• W2012078396 cites W2092959146 @default.
• W2012078396 cites W2094073595 @default.
• W2012078396 cites W2099450092 @default.
• W2012078396 cites W2101148603 @default.
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• W2012078396 cites W2115682148 @default.
• W2012078396 cites W2123838890 @default.
• W2012078396 cites W2127810309 @default.
• W2012078396 cites W2135271276 @default.
• W2012078396 cites W2141290457 @default.
• W2012078396 cites W2144891092 @default.
• W2012078396 cites W2146517909 @default.
• W2012078396 cites W2147670920 @default.
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• W2012078396 cites W2154575100 @default.
• W2012078396 cites W2158496649 @default.
• W2012078396 cites W2166540950 @default.
• W2012078396 cites W2169062325 @default.
• W2012078396 cites W2169542007 @default.
• W2012078396 cites W2171916720 @default.
• W2012078396 cites W2396170582 @default.
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• W2012078396 doi "https://doi.org/10.1523/jneurosci.3630-12.2012" @default.
• W2012078396 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3276112" @default.
• W2012078396 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22279202" @default.
• W2012078396 hasPublicationYear "2012" @default.
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