FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2012078920> ?p ?o ?g. }

• W2012078920 endingPage "595" @default.
• W2012078920 startingPage "586" @default.
• W2012078920 abstract "Reduced fetal growth has been closely associated with an increased risk for the development of chronic disease in later life. Accumulating evidence indicates that fetal exposure to excess glucocorticoids represents a critical mechanism underlying this association. Approximately 7% of pregnant women are at risk of preterm delivery and these women are routinely treated with synthetic glucocorticoids (sGC) between 24 and 34 of weeks gestation to improve neonatal outcome. Animal studies have demonstrated that maternally administered sGC crosses the placenta, affecting fetal hypothalamic-pituitary-adrenal (HPA) development, resulting in changes in HPA axis function that persist throughout life. These changes appear to be modulated at the level of glucocorticoid receptors (GR) and mineralocorticoid receptors (MR) in the brain and pituitary. As the HPA axis interacts with many other physiological pathways, the changes in endocrine function are also sex-specific and age-dependent. Alterations in behavior, particularly locomotion, in animals exposed to sGC in utero have also been demonstrated. Consistent with the finding in animal models, emerging human data are indicating attention deficit-hyperactivity disorder (ADHD)-like symptoms in children exposed to repeated courses of sGC in utero. This behavioral phenotype is likely linked to alterations in dopamine (DA) signaling, suggesting that sGC are able to permanently modify or 'program' this system. Finally, it is emerging that changes in HPA axis function and behavior following antenatal exposure to sGC are transgenerational and likely involve epigenetic mechanisms. A comprehensive understanding of the acute and long-term impact of sGC exposure in utero is necessary to begin to develop recommendations and treatment options for pregnant women at risk of preterm delivery." @default.
• W2012078920 created "2016-06-24" @default.
• W2012078920 creator A5012295903 @default.
• W2012078920 creator A5037762972 @default.
• W2012078920 creator A5071397090 @default.
• W2012078920 date "2008-03-01" @default.
• W2012078920 modified "2023-10-03" @default.
• W2012078920 title "Fetal programming of hypothalamic–pituitary–adrenal (HPA) axis function and behavior by synthetic glucocorticoids" @default.
• W2012078920 cites W1496119708 @default.
• W2012078920 cites W1497498736 @default.
• W2012078920 cites W1527534059 @default.
• W2012078920 cites W1532296443 @default.
• W2012078920 cites W1537578955 @default.
• W2012078920 cites W1544278771 @default.
• W2012078920 cites W1547061295 @default.
• W2012078920 cites W1547452419 @default.
• W2012078920 cites W1838549903 @default.
• W2012078920 cites W1886309510 @default.
• W2012078920 cites W1932533342 @default.
• W2012078920 cites W1965166228 @default.
• W2012078920 cites W1968341955 @default.
• W2012078920 cites W1975066103 @default.
• W2012078920 cites W1975231696 @default.
• W2012078920 cites W1976062681 @default.
• W2012078920 cites W1976372065 @default.
• W2012078920 cites W1976464755 @default.
• W2012078920 cites W1984224154 @default.
• W2012078920 cites W1985281892 @default.
• W2012078920 cites W1986667734 @default.
• W2012078920 cites W1992285829 @default.
• W2012078920 cites W1994520348 @default.
• W2012078920 cites W1996477944 @default.
• W2012078920 cites W1999105866 @default.
• W2012078920 cites W2001688956 @default.
• W2012078920 cites W2006493242 @default.
• W2012078920 cites W2007005063 @default.
• W2012078920 cites W2011083427 @default.
• W2012078920 cites W2014029070 @default.
• W2012078920 cites W2016339543 @default.
• W2012078920 cites W2019400672 @default.
• W2012078920 cites W2020232631 @default.
• W2012078920 cites W2020469940 @default.
• W2012078920 cites W2021031411 @default.
• W2012078920 cites W2022892231 @default.
• W2012078920 cites W2024746554 @default.
• W2012078920 cites W2025047921 @default.
• W2012078920 cites W2026754089 @default.
• W2012078920 cites W2027760035 @default.
• W2012078920 cites W2027985523 @default.
• W2012078920 cites W2028533496 @default.
• W2012078920 cites W2031752348 @default.
• W2012078920 cites W2035000881 @default.
• W2012078920 cites W2035308427 @default.
• W2012078920 cites W2036598382 @default.
• W2012078920 cites W2036740896 @default.
• W2012078920 cites W2038199976 @default.
• W2012078920 cites W2038673601 @default.
• W2012078920 cites W2039282773 @default.
• W2012078920 cites W2041013321 @default.
• W2012078920 cites W2041607042 @default.
• W2012078920 cites W2043603348 @default.
• W2012078920 cites W2047358716 @default.
• W2012078920 cites W2048920034 @default.
• W2012078920 cites W2050766410 @default.
• W2012078920 cites W2055001133 @default.
• W2012078920 cites W2057395782 @default.
• W2012078920 cites W2061318641 @default.
• W2012078920 cites W2068799943 @default.
• W2012078920 cites W2073214657 @default.
• W2012078920 cites W2073793623 @default.
• W2012078920 cites W2076404033 @default.
• W2012078920 cites W2080131125 @default.
• W2012078920 cites W2084462922 @default.
• W2012078920 cites W2092684842 @default.
• W2012078920 cites W2094183267 @default.
• W2012078920 cites W2095529067 @default.
• W2012078920 cites W2101153618 @default.
• W2012078920 cites W2103873915 @default.
• W2012078920 cites W2104624454 @default.
• W2012078920 cites W2112103177 @default.
• W2012078920 cites W2113680708 @default.
• W2012078920 cites W2116629441 @default.
• W2012078920 cites W2117733693 @default.
• W2012078920 cites W2119883401 @default.
• W2012078920 cites W2121411996 @default.
• W2012078920 cites W2123051717 @default.
• W2012078920 cites W2123481286 @default.
• W2012078920 cites W2126848882 @default.
• W2012078920 cites W2128803592 @default.
• W2012078920 cites W2130093713 @default.
• W2012078920 cites W2132585563 @default.
• W2012078920 cites W2132818745 @default.
• W2012078920 cites W2136828755 @default.
• W2012078920 cites W2144563590 @default.
• W2012078920 cites W2145750641 @default.
• W2012078920 cites W2160398153 @default.
• W2012078920 cites W2161277545 @default.
• W2012078920 cites W2162438271 @default.

• next