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- W2012079261 abstract "The many attempts to identify genes for bipolar disorder (BD) have met with limited success, which has generally been attributed to genetic heterogeneity and small gene effects. However, it is also possible that the categorical phenotypes used in genetic studies of BD are not the most informative or biologically relevant. We have explored aspects of temperament as quantitative phenotypes for BD through the use of the Temperament Evaluation of Memphis, Pisa, Paris, and San Diego Auto-questionnaire (TEMPS-A), which is designed to assess lifelong, milder aspects of bipolar symptomatology and defines five temperaments: hyperthymic, dysthymic, cyclothymic, irritable, and anxious. We compared temperament scores between diagnostic groups and assessed heritability in a sample of 101 families collected for genetic studies of BD. A genome-wide SNP linkage study was then performed in the subset of 51 families for which genetic data was available. Significant group differences were observed between BD subjects, their first-degree relatives, and independent controls, and all five temperaments were found to be significantly heritable, with heritabilities ranging from 21% for the hyperthymic to 52% for the irritable temperaments. Suggestive evidence for linkage was observed for the hyperthymic (chromosomes 1q44, 2p16, 6q16, and 14q23), dysthymic (chromosomes 3p21 and 13q34), and irritable (chromosome 6q24) temperaments. The relatively small size of our linkage sample likely limited our ability to reach genome-wide significance in this study. While not genome-wide significant, these results suggest that aspects of temperament may prove useful in the identification of genes underlying BD susceptibility." @default.
- W2012079261 created "2016-06-24" @default.
- W2012079261 creator A5016043879 @default.
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- W2012079261 creator A5079329164 @default.
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- W2012079261 date "2013-09-01" @default.
- W2012079261 modified "2023-10-17" @default.
- W2012079261 title "Heritability and genome-wide SNP linkage analysis of temperament in bipolar disorder" @default.
- W2012079261 cites W119875242 @default.
- W2012079261 cites W1545695267 @default.
- W2012079261 cites W1548707190 @default.
- W2012079261 cites W1557029624 @default.
- W2012079261 cites W1882303649 @default.
- W2012079261 cites W1966111889 @default.
- W2012079261 cites W1966460145 @default.
- W2012079261 cites W1966483969 @default.
- W2012079261 cites W1966646865 @default.
- W2012079261 cites W1971916688 @default.
- W2012079261 cites W1972298322 @default.
- W2012079261 cites W1976358763 @default.
- W2012079261 cites W1978480599 @default.
- W2012079261 cites W1980502525 @default.
- W2012079261 cites W1980806190 @default.
- W2012079261 cites W1984636702 @default.
- W2012079261 cites W1984906757 @default.
- W2012079261 cites W1993588417 @default.
- W2012079261 cites W1996124672 @default.
- W2012079261 cites W1996545137 @default.
- W2012079261 cites W1996805443 @default.
- W2012079261 cites W2003491970 @default.
- W2012079261 cites W2010216869 @default.
- W2012079261 cites W2019932550 @default.
- W2012079261 cites W2020451388 @default.
- W2012079261 cites W2021106046 @default.
- W2012079261 cites W2023519015 @default.
- W2012079261 cites W2026608599 @default.
- W2012079261 cites W2033276865 @default.
- W2012079261 cites W2042718111 @default.
- W2012079261 cites W2042739521 @default.
- W2012079261 cites W2044394153 @default.
- W2012079261 cites W2056206967 @default.
- W2012079261 cites W2057682817 @default.
- W2012079261 cites W2060141818 @default.
- W2012079261 cites W2062466820 @default.
- W2012079261 cites W2063619823 @default.
- W2012079261 cites W2067761130 @default.
- W2012079261 cites W2071128065 @default.
- W2012079261 cites W2077192176 @default.
- W2012079261 cites W2078625752 @default.
- W2012079261 cites W2081030569 @default.
- W2012079261 cites W2081703948 @default.
- W2012079261 cites W2089359615 @default.
- W2012079261 cites W2095821536 @default.
- W2012079261 cites W2096581460 @default.
- W2012079261 cites W2099194304 @default.
- W2012079261 cites W2101214496 @default.
- W2012079261 cites W2101581938 @default.
- W2012079261 cites W2103189755 @default.
- W2012079261 cites W2104418842 @default.
- W2012079261 cites W2104743461 @default.
- W2012079261 cites W2105257553 @default.
- W2012079261 cites W2105306382 @default.
- W2012079261 cites W2108284636 @default.
- W2012079261 cites W2110334080 @default.
- W2012079261 cites W2113779935 @default.
- W2012079261 cites W2115335486 @default.
- W2012079261 cites W2117950559 @default.
- W2012079261 cites W2118455346 @default.
- W2012079261 cites W2122796918 @default.
- W2012079261 cites W2125566175 @default.
- W2012079261 cites W2126236504 @default.
- W2012079261 cites W2127442418 @default.
- W2012079261 cites W2127960585 @default.
- W2012079261 cites W2129284833 @default.
- W2012079261 cites W2129330384 @default.
- W2012079261 cites W2134783591 @default.
- W2012079261 cites W2134808298 @default.
- W2012079261 cites W2136702573 @default.
- W2012079261 cites W2143422704 @default.
- W2012079261 cites W2144506766 @default.
- W2012079261 cites W2147718673 @default.
- W2012079261 cites W2150763276 @default.
- W2012079261 cites W2151566815 @default.
- W2012079261 cites W2157659172 @default.
- W2012079261 cites W2158370744 @default.
- W2012079261 cites W2161641617 @default.
- W2012079261 cites W2165433062 @default.
- W2012079261 cites W2165540187 @default.
- W2012079261 cites W2168802470 @default.
- W2012079261 cites W2170335947 @default.
- W2012079261 cites W2171717223 @default.
- W2012079261 cites W2405069971 @default.