Matches in SemOpenAlex for { <https://semopenalex.org/work/W2012079473> ?p ?o ?g. }
- W2012079473 abstract "Corticospinal tract is mainly descending tracts by dominating voluntary movement of the limbs and fine movement of distal limb, especially in mammals. Distal axonal degeneration is called anterograde degeneration. Proximal end is connected to the neuron cell body, whereas retrograde degeneration is very slight with the possibility of regeneration. MicroRNAs (miRNAs) are a short non-coding RNAs that regulate gene expression at the post-transcriptional level by binding with the 3' untranslated region of target mRNAs. In order to understand the mechanism of underlying gene alteration in the rostral and caudal, respectively, after the corticospinal tract injury, we analyzed rostral and caudal mRNA and miRNA, respectively, using microRNA and mRNA profiles. We combined the predicted targets of miRNA with differentially expressed mRNA for selecting intersection gene. To predict the function miRNAs, GO and KEGG enrichment analysis were performed to find genes associated with change of rostral and caudal, respectively. The bioinformatics analysis indicated that changes in miRNA and target mRNA expression affected rostral regeneration, including negative regulation of apoptosis, positive regulation of cell proliferation, cell adhesion, oligodendrocyte development etc. It also affected caudal degeneration, including induction of apoptosis, down-regulating nervous system development, immune response etc. The current results illustrated that corticospinal tract injury produces a wide range changes of miRNAs, whereas mRNA also showed significantly change which affects key biological processes after injury in rostral and caudal." @default.
- W2012079473 created "2016-06-24" @default.
- W2012079473 creator A5002616304 @default.
- W2012079473 creator A5007404705 @default.
- W2012079473 creator A5018794755 @default.
- W2012079473 creator A5022761731 @default.
- W2012079473 creator A5035168940 @default.
- W2012079473 creator A5040891414 @default.
- W2012079473 creator A5043930065 @default.
- W2012079473 creator A5088072412 @default.
- W2012079473 date "2014-04-01" @default.
- W2012079473 modified "2023-10-16" @default.
- W2012079473 title "Potential role of microRNA: Identification and functional analysis of microRNA in corticospinal tract after unilateral lesions of the medullary pyramid" @default.
- W2012079473 cites W123913560 @default.
- W2012079473 cites W1431520658 @default.
- W2012079473 cites W144423133 @default.
- W2012079473 cites W1621337337 @default.
- W2012079473 cites W1885960134 @default.
- W2012079473 cites W1966758310 @default.
- W2012079473 cites W1976990591 @default.
- W2012079473 cites W1980148614 @default.
- W2012079473 cites W1986005801 @default.
- W2012079473 cites W1988875977 @default.
- W2012079473 cites W1993421868 @default.
- W2012079473 cites W2006517495 @default.
- W2012079473 cites W2010597994 @default.
- W2012079473 cites W2014946489 @default.
- W2012079473 cites W2021439150 @default.
- W2012079473 cites W2025787566 @default.
- W2012079473 cites W2028651825 @default.
- W2012079473 cites W2034546140 @default.
- W2012079473 cites W2038811384 @default.
- W2012079473 cites W2040199078 @default.
- W2012079473 cites W2046485522 @default.
- W2012079473 cites W2049646029 @default.
- W2012079473 cites W2049893910 @default.
- W2012079473 cites W2050091174 @default.
- W2012079473 cites W2053038848 @default.
- W2012079473 cites W2054010777 @default.
- W2012079473 cites W2054245229 @default.
- W2012079473 cites W2064566258 @default.
- W2012079473 cites W2065446314 @default.
- W2012079473 cites W2069025840 @default.
- W2012079473 cites W2108399976 @default.
- W2012079473 cites W2135920287 @default.
- W2012079473 cites W2142219882 @default.
- W2012079473 cites W2149538964 @default.
- W2012079473 cites W2151293405 @default.
- W2012079473 cites W2159752654 @default.
- W2012079473 cites W2397749376 @default.
- W2012079473 doi "https://doi.org/10.1016/j.neulet.2013.12.050" @default.
- W2012079473 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24513234" @default.
- W2012079473 hasPublicationYear "2014" @default.
- W2012079473 type Work @default.
- W2012079473 sameAs 2012079473 @default.
- W2012079473 citedByCount "1" @default.
- W2012079473 countsByYear W20120794732018 @default.
- W2012079473 crossrefType "journal-article" @default.
- W2012079473 hasAuthorship W2012079473A5002616304 @default.
- W2012079473 hasAuthorship W2012079473A5007404705 @default.
- W2012079473 hasAuthorship W2012079473A5018794755 @default.
- W2012079473 hasAuthorship W2012079473A5022761731 @default.
- W2012079473 hasAuthorship W2012079473A5035168940 @default.
- W2012079473 hasAuthorship W2012079473A5040891414 @default.
- W2012079473 hasAuthorship W2012079473A5043930065 @default.
- W2012079473 hasAuthorship W2012079473A5088072412 @default.
- W2012079473 hasConcept C104317684 @default.
- W2012079473 hasConcept C105702510 @default.
- W2012079473 hasConcept C126838900 @default.
- W2012079473 hasConcept C143409427 @default.
- W2012079473 hasConcept C145059251 @default.
- W2012079473 hasConcept C149550507 @default.
- W2012079473 hasConcept C150194340 @default.
- W2012079473 hasConcept C169760540 @default.
- W2012079473 hasConcept C2779779279 @default.
- W2012079473 hasConcept C54355233 @default.
- W2012079473 hasConcept C71924100 @default.
- W2012079473 hasConcept C86803240 @default.
- W2012079473 hasConcept C95444343 @default.
- W2012079473 hasConceptScore W2012079473C104317684 @default.
- W2012079473 hasConceptScore W2012079473C105702510 @default.
- W2012079473 hasConceptScore W2012079473C126838900 @default.
- W2012079473 hasConceptScore W2012079473C143409427 @default.
- W2012079473 hasConceptScore W2012079473C145059251 @default.
- W2012079473 hasConceptScore W2012079473C149550507 @default.
- W2012079473 hasConceptScore W2012079473C150194340 @default.
- W2012079473 hasConceptScore W2012079473C169760540 @default.
- W2012079473 hasConceptScore W2012079473C2779779279 @default.
- W2012079473 hasConceptScore W2012079473C54355233 @default.
- W2012079473 hasConceptScore W2012079473C71924100 @default.
- W2012079473 hasConceptScore W2012079473C86803240 @default.
- W2012079473 hasConceptScore W2012079473C95444343 @default.
- W2012079473 hasLocation W20120794731 @default.
- W2012079473 hasLocation W20120794732 @default.
- W2012079473 hasOpenAccess W2012079473 @default.
- W2012079473 hasPrimaryLocation W20120794731 @default.
- W2012079473 hasRelatedWork W2044997719 @default.
- W2012079473 hasRelatedWork W2116982032 @default.
- W2012079473 hasRelatedWork W2589061078 @default.
- W2012079473 hasRelatedWork W2594860815 @default.