FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2012079485> ?p ?o ?g. }

• W2012079485 endingPage "1061" @default.
• W2012079485 startingPage "1052" @default.
• W2012079485 abstract "Molecular imaging aims at sensing specific molecular targets, fundamental biological processes, and certain cell types in living subjects. An integrative discipline rooted in the biological, chemical, and imaging sciences, molecular imaging has broad applications in biology and drug discovery1–5 and increasingly within cardiovascular disease.6–12 Before discussing key factors spurring the growth of this field, we first briefly review 2 essential components of this technology: imaging agents and imaging hardware.Molecular imaging requires highly sensitive and specific imaging agents. Such agents incorporate 2 key factors: (1) a signal detection compound and the corresponding imaging hardware platform and (2) an affinity ligand that recognizes the intended molecular or cellular target. Favorable targets include those with established biological and clinical importance in a disease of interest, as well as targets with inherent signal amplification potential such as internalizing receptors or enzymes. Inaccessible and low-abundance targets (DNA, RNA, sparsely expressed proteins) present greater challenges, particularly in a noninvasive, clinical setting.Signal detection compounds include radioisotopes for positron emission tomography (PET) and single-photon-emission computed tomography (SPECT) imaging, paramagnetic (gadolinium)/superparamagnetic (iron oxide) agents for magnetic resonance imaging (MRI), fluorochromes for near-infrared fluorescence imaging, and microbubbles for ultrasound imaging. Certain agents can exhibit unique physical changes favorable for signal amplification when spaced close together (eg, quenching of fluorochromes13–18 or augmented relaxivity of magnetic substrates19–21). These tags can form the basis of imaging agents with inherent chemical amplification capabilities. Amplification strategies generally enable higher target-to-background ratios, a key strategy for developing sufficiently sensitive agents for clinical use.Affinity ligands confer molecular or cellular specificity for the target of interest. The application of novel ligand screening methods, emerging new chemistries for conjugation and signal amplification, and nanotechnology have fostered substantial growth in ligand development. From a clinical perspective, qualities of an ideal ligand include (1) …" @default.
• W2012079485 created "2016-06-24" @default.
• W2012079485 creator A5035255903 @default.
• W2012079485 creator A5043201732 @default.
• W2012079485 creator A5067255019 @default.
• W2012079485 date "2007-08-28" @default.
• W2012079485 modified "2023-10-13" @default.
• W2012079485 title "Molecular Imaging of Cardiovascular Disease" @default.
• W2012079485 cites W1501982791 @default.
• W2012079485 cites W1532250764 @default.
• W2012079485 cites W1561193751 @default.
• W2012079485 cites W1969492846 @default.
• W2012079485 cites W1972582749 @default.
• W2012079485 cites W1973523151 @default.
• W2012079485 cites W1977222829 @default.
• W2012079485 cites W1979740301 @default.
• W2012079485 cites W1983549854 @default.
• W2012079485 cites W1984336760 @default.
• W2012079485 cites W1986805734 @default.
• W2012079485 cites W1987533231 @default.
• W2012079485 cites W1988072585 @default.
• W2012079485 cites W1988893964 @default.
• W2012079485 cites W1993157780 @default.
• W2012079485 cites W1995431655 @default.
• W2012079485 cites W1997586556 @default.
• W2012079485 cites W1998782296 @default.
• W2012079485 cites W2002718660 @default.
• W2012079485 cites W2008457366 @default.
• W2012079485 cites W2014945829 @default.
• W2012079485 cites W2017506762 @default.
• W2012079485 cites W2023663301 @default.
• W2012079485 cites W2024021832 @default.
• W2012079485 cites W2028063382 @default.
• W2012079485 cites W2029773366 @default.
• W2012079485 cites W2035883624 @default.
• W2012079485 cites W2037057361 @default.
• W2012079485 cites W2039026859 @default.
• W2012079485 cites W2039601697 @default.
• W2012079485 cites W2039881470 @default.
• W2012079485 cites W2039963413 @default.
• W2012079485 cites W2049815086 @default.
• W2012079485 cites W2052088499 @default.
• W2012079485 cites W2052098523 @default.
• W2012079485 cites W2058821631 @default.
• W2012079485 cites W2059246878 @default.
• W2012079485 cites W2061006668 @default.
• W2012079485 cites W2064645407 @default.
• W2012079485 cites W2065182922 @default.
• W2012079485 cites W2066963386 @default.
• W2012079485 cites W2072242219 @default.
• W2012079485 cites W2072715455 @default.
• W2012079485 cites W2075048068 @default.
• W2012079485 cites W2078683567 @default.
• W2012079485 cites W2080656903 @default.
• W2012079485 cites W2083863641 @default.
• W2012079485 cites W2084693381 @default.
• W2012079485 cites W2085736171 @default.
• W2012079485 cites W2087728676 @default.
• W2012079485 cites W2090863707 @default.
• W2012079485 cites W2093718909 @default.
• W2012079485 cites W2096045982 @default.
• W2012079485 cites W2099365062 @default.
• W2012079485 cites W2101037111 @default.
• W2012079485 cites W2101681003 @default.
• W2012079485 cites W2102248106 @default.
• W2012079485 cites W2106203321 @default.
• W2012079485 cites W2108524724 @default.
• W2012079485 cites W2110403270 @default.
• W2012079485 cites W2112285684 @default.
• W2012079485 cites W2113136548 @default.
• W2012079485 cites W2113580829 @default.
• W2012079485 cites W2113930687 @default.
• W2012079485 cites W2116810900 @default.
• W2012079485 cites W2119507443 @default.
• W2012079485 cites W2129445703 @default.
• W2012079485 cites W2130796239 @default.
• W2012079485 cites W2131299942 @default.
• W2012079485 cites W2132746436 @default.
• W2012079485 cites W2135153062 @default.
• W2012079485 cites W2139409935 @default.
• W2012079485 cites W2144705350 @default.
• W2012079485 cites W2146595692 @default.
• W2012079485 cites W2148026867 @default.
• W2012079485 cites W2148225980 @default.
• W2012079485 cites W2148706200 @default.
• W2012079485 cites W2151790333 @default.
• W2012079485 cites W2157070021 @default.
• W2012079485 cites W2161739492 @default.
• W2012079485 cites W2162666572 @default.
• W2012079485 cites W2162771855 @default.
• W2012079485 cites W2165738780 @default.
• W2012079485 cites W2169410333 @default.
• W2012079485 cites W2172157091 @default.
• W2012079485 cites W2186448008 @default.
• W2012079485 cites W2335455113 @default.
• W2012079485 cites W4240900378 @default.
• W2012079485 cites W74127843 @default.
• W2012079485 cites W2146136758 @default.

• next