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- W2012079640 abstract "The metabolism by the intact bovine lens of l-[U-14C]glutamine has been studied and compared with that of l-[U-14C]glutamate. [14C]Glutamine was taken up and oxidized to 14CO2 at three times the rate of [14C]glutamate. [14C]Glutamine was largely converted to [14C]glutamate, which was found in the lens in the free form, in glutathione and in protein. Proline and three unidentified compounds were also labelled. The presence of unlabelled 2 mm-glutamine greatly reduced the production of 14CO2 and labelled protein from 5 μm[14C]glutamate, whereas unlabelled 2 mm-glutamate had little effect on the metabolism of 5 μm [14C]glutamine. The concentration of free glutamate in the lens was greater after incubation with 2 mm-glutamine than with 2 mm-glutamate. Glutamine and glutamate were assayed in the lens and aqueous humour. The ratio of concentrations in lens water to that in the aqueous humour is about 10·7 for glutamate and 0·55 for glutamine." @default.
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- W2012079640 date "1973-10-01" @default.
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- W2012079640 title "The metabolism of glutamine in the bovine lens: Glutamine as a source of glutamate" @default.
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- W2012079640 doi "https://doi.org/10.1016/0014-4835(73)90204-2" @default.
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