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• W2012080116 abstract "Introduction . The relation between minute ventilation (VE) and carbon dioxide production (VCO 2 ) can be characterised by the instantaneous ratio of ventilation to carbon dioxide production, the ventilatory equivalent for CO 2 (VEqCO 2 ). We hypothesised that the time taken to achieve the lowest VEqCO 2 (time to VEqCO2 nadir) may be a prognostic marker in patients with chronic heart failure (CHF). Methods . Patients and healthy controls underwent a symptom-limited, cardiopulmonary exercise test (CPET) on a treadmill to volitional exhaustion. Results . 423 patients with CHF (mean age years; 80% males) and 78 healthy controls (62% males; age years) were recruited. Time to VEqCO2 nadir was shorter in patients than controls ( s versus s; ). Univariable predictors of all-cause mortality included peak oxygen uptake (), VEqCO 2 nadir (), and time to VEqCO 2 nadir (). In an adjusted Cox multivariable proportional hazards model, peak oxygen uptake () and VEqCO 2 nadir () were the most significant independent predictors of all-cause mortality. Conclusion . The time to VEqCO 2 nadir was shorter in patients with CHF than in normal subjects and was a predictor of subsequent mortality." @default.
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• W2012080116 date "2012-01-01" @default.
• W2012080116 modified "2023-10-16" @default.
• W2012080116 title "Abnormalities of the Ventilatory Equivalent for Carbon Dioxide in Patients with Chronic Heart Failure" @default.
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• W2012080116 doi "https://doi.org/10.1155/2012/589164" @default.
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