FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2012080407> ?p ?o ?g. }

• W2012080407 endingPage "359" @default.
• W2012080407 startingPage "352" @default.
• W2012080407 abstract "Progression of cells through the G1 phase of the cell cycle requires the assembly and activation of specific cyclin:cyclin-dependent kinase (cdk) complexes in a tightly regulated, sequential fashion. To more clearly define the temporal events leading to the G1/S transition, sequential changes in the expression of cyclin E and cdks 2, 4, and 6, as well as the phosphorylation of the retinoblastoma protein (pRb), were assayed in RA28 cells, a variant of human colon cancer RKO cells which were modified by transfection of an ecdysone-inducible antisense (AS) CD1 expression system. Induction of cyclin D1 antisense mRNA by the ecdysteroid, ponasterone A, resulted in a 55% decrease in cyclin D1 mRNA and a 58% decrease in CD1 protein levels. There was a 2.4-fold decrease in the ratio of hyperphosphorylated pRb (ppRb) to hypophosphorylated pRb, as well as a 60–75% decrease in cdk 2- and cdk 4-specific phosphorylated pRb proteins. Of interest, cyclin E-dependent phosphorylation (cdk2) decreased 2.5-fold at 3 h despite only a 30% decrease in cyclin E protein level. Levels of cdk 2, cdk 4, and cdk 6 decreased 40–70%, while levels of cyclin A and B were unaffected by induction of CD1 antisense. Induction of a CD1 antisense gene in a human colon cancer cell line resulted in rapid, concomitant changes in CD1 mRNA and protein, cyclin E, cdk2, cdk4, and cdk6, as well as the ratio of ppRb to pRb. In this system, growth regulatory events are tightly regulated and the perturbed expression of a single protein, CD1, rapidly alters expression of multiple regulatory proteins involved in the G1/S transition phase of cell cycle progression." @default.
• W2012080407 created "2016-06-24" @default.
• W2012080407 creator A5016235708 @default.
• W2012080407 creator A5026390249 @default.
• W2012080407 creator A5039355847 @default.
• W2012080407 creator A5053282401 @default.
• W2012080407 creator A5071579916 @default.
• W2012080407 date "2000-06-01" @default.
• W2012080407 modified "2023-10-14" @default.
• W2012080407 title "Downregulation of Cyclin D1 Alters cdk 4- and cdk 2-Specific Phosphorylation of Retinoblastoma Protein" @default.
• W2012080407 cites W1979647722 @default.
• W2012080407 cites W1979669293 @default.
• W2012080407 cites W1981939829 @default.
• W2012080407 cites W1982245444 @default.
• W2012080407 cites W1984509210 @default.
• W2012080407 cites W1988607142 @default.
• W2012080407 cites W1990925999 @default.
• W2012080407 cites W1999876280 @default.
• W2012080407 cites W2000518052 @default.
• W2012080407 cites W2027376766 @default.
• W2012080407 cites W2027558915 @default.
• W2012080407 cites W2029080338 @default.
• W2012080407 cites W2035978064 @default.
• W2012080407 cites W2041003951 @default.
• W2012080407 cites W2045463072 @default.
• W2012080407 cites W2051724614 @default.
• W2012080407 cites W2058271447 @default.
• W2012080407 cites W2058879820 @default.
• W2012080407 cites W2063110155 @default.
• W2012080407 cites W2078119356 @default.
• W2012080407 cites W2090303261 @default.
• W2012080407 cites W2099925982 @default.
• W2012080407 cites W2119874496 @default.
• W2012080407 cites W2128739161 @default.
• W2012080407 cites W2133697463 @default.
• W2012080407 cites W2167198441 @default.
• W2012080407 cites W2170659948 @default.
• W2012080407 doi "https://doi.org/10.1006/mcbr.2000.0238" @default.
• W2012080407 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11032757" @default.
• W2012080407 hasPublicationYear "2000" @default.
• W2012080407 type Work @default.
• W2012080407 sameAs 2012080407 @default.
• W2012080407 citedByCount "35" @default.
• W2012080407 countsByYear W20120804072012 @default.
• W2012080407 countsByYear W20120804072014 @default.
• W2012080407 countsByYear W20120804072015 @default.
• W2012080407 countsByYear W20120804072016 @default.
• W2012080407 countsByYear W20120804072017 @default.
• W2012080407 countsByYear W20120804072018 @default.
• W2012080407 countsByYear W20120804072019 @default.
• W2012080407 countsByYear W20120804072020 @default.
• W2012080407 countsByYear W20120804072021 @default.
• W2012080407 countsByYear W20120804072023 @default.
• W2012080407 crossrefType "journal-article" @default.
• W2012080407 hasAuthorship W2012080407A5016235708 @default.
• W2012080407 hasAuthorship W2012080407A5026390249 @default.
• W2012080407 hasAuthorship W2012080407A5039355847 @default.
• W2012080407 hasAuthorship W2012080407A5053282401 @default.
• W2012080407 hasAuthorship W2012080407A5071579916 @default.
• W2012080407 hasConcept C11882975 @default.
• W2012080407 hasConcept C11960822 @default.
• W2012080407 hasConcept C120089663 @default.
• W2012080407 hasConcept C124320809 @default.
• W2012080407 hasConcept C1491633281 @default.
• W2012080407 hasConcept C153911025 @default.
• W2012080407 hasConcept C16438837 @default.
• W2012080407 hasConcept C199649820 @default.
• W2012080407 hasConcept C199835354 @default.
• W2012080407 hasConcept C2776062698 @default.
• W2012080407 hasConcept C2778298596 @default.
• W2012080407 hasConcept C28179978 @default.
• W2012080407 hasConcept C29537977 @default.
• W2012080407 hasConcept C502942594 @default.
• W2012080407 hasConcept C55493867 @default.
• W2012080407 hasConcept C82495950 @default.
• W2012080407 hasConcept C86803240 @default.
• W2012080407 hasConcept C94561458 @default.
• W2012080407 hasConcept C95444343 @default.
• W2012080407 hasConcept C97029542 @default.
• W2012080407 hasConcept C9743823 @default.
• W2012080407 hasConceptScore W2012080407C11882975 @default.
• W2012080407 hasConceptScore W2012080407C11960822 @default.
• W2012080407 hasConceptScore W2012080407C120089663 @default.
• W2012080407 hasConceptScore W2012080407C124320809 @default.
• W2012080407 hasConceptScore W2012080407C1491633281 @default.
• W2012080407 hasConceptScore W2012080407C153911025 @default.
• W2012080407 hasConceptScore W2012080407C16438837 @default.
• W2012080407 hasConceptScore W2012080407C199649820 @default.
• W2012080407 hasConceptScore W2012080407C199835354 @default.
• W2012080407 hasConceptScore W2012080407C2776062698 @default.
• W2012080407 hasConceptScore W2012080407C2778298596 @default.
• W2012080407 hasConceptScore W2012080407C28179978 @default.
• W2012080407 hasConceptScore W2012080407C29537977 @default.
• W2012080407 hasConceptScore W2012080407C502942594 @default.
• W2012080407 hasConceptScore W2012080407C55493867 @default.
• W2012080407 hasConceptScore W2012080407C82495950 @default.
• W2012080407 hasConceptScore W2012080407C86803240 @default.
• W2012080407 hasConceptScore W2012080407C94561458 @default.

• next