Matches in SemOpenAlex for { <https://semopenalex.org/work/W2012080456> ?p ?o ?g. }
Showing items 1 to 97 of
97
with 100 items per page.
- W2012080456 endingPage "345" @default.
- W2012080456 startingPage "340" @default.
- W2012080456 abstract "Chondrocytes lose their phenotypic traits, including type II collagen, after serial passage in monolayer cultures. Osteogenin, a bone morphogenetic protein, induces cartilage and bone in nonskeletal sites. This investigation examined the ability of osteogenin to promote the reexpression of cartilage phenotype by dedifferentiated chondrocytes obtained from rabbit articular cartilage. The results revealed that osteogenin, in synergism with selected growth factors, promoted the reexpression of type II collagen and proteoglycans by dedifferentiated chondrocytes in agarose. Insulin, a constituent of the basal medium, appeared to be essential for the colony-forming aspect of this phenomenon, since when insulin was replaced by insulin-like growth factor-1 colony formation did not occur. Epidermal growth factor, platelet-derived growth factor (PDGF), and basic fibroblast growth factor appeared to be an optimal combination for the action of osteogenin. Neutralizing antibodies to transforming growth factor-beta did not influence the response to osteogenin. It is noteworthy that, compared to freshly passaged cells, those stored in liquid nitrogen were not as responsive to osteogenin and growth factors. A higher concentration of fibroblast growth factor in conjunction with osteogenin and PDGF, increased the responsiveness of frozen cells only in part, as the Alcian blue-positive proteoglycan matrix was not restored completely." @default.
- W2012080456 created "2016-06-24" @default.
- W2012080456 creator A5040780928 @default.
- W2012080456 creator A5051479554 @default.
- W2012080456 creator A5059823367 @default.
- W2012080456 date "1991-02-01" @default.
- W2012080456 modified "2023-09-23" @default.
- W2012080456 title "Osteogenin promotes reexpression of cartilage phenotype by dedifferentiated articular chondrocytes in serum-free medium" @default.
- W2012080456 cites W1517038772 @default.
- W2012080456 cites W1590193762 @default.
- W2012080456 cites W1967269017 @default.
- W2012080456 cites W1968822620 @default.
- W2012080456 cites W1971108302 @default.
- W2012080456 cites W1986469118 @default.
- W2012080456 cites W1996487528 @default.
- W2012080456 cites W1997454006 @default.
- W2012080456 cites W2000172237 @default.
- W2012080456 cites W2035538985 @default.
- W2012080456 cites W2039019631 @default.
- W2012080456 cites W2050273631 @default.
- W2012080456 cites W2050825830 @default.
- W2012080456 cites W2064930094 @default.
- W2012080456 cites W2067248474 @default.
- W2012080456 cites W2070038994 @default.
- W2012080456 cites W2088085332 @default.
- W2012080456 cites W2096904163 @default.
- W2012080456 cites W2099292585 @default.
- W2012080456 cites W2130486107 @default.
- W2012080456 cites W2134335726 @default.
- W2012080456 cites W2151370338 @default.
- W2012080456 doi "https://doi.org/10.1016/0014-4827(91)90050-5" @default.
- W2012080456 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1988283" @default.
- W2012080456 hasPublicationYear "1991" @default.
- W2012080456 type Work @default.
- W2012080456 sameAs 2012080456 @default.
- W2012080456 citedByCount "43" @default.
- W2012080456 countsByYear W20120804562015 @default.
- W2012080456 countsByYear W20120804562016 @default.
- W2012080456 countsByYear W20120804562017 @default.
- W2012080456 crossrefType "journal-article" @default.
- W2012080456 hasAuthorship W2012080456A5040780928 @default.
- W2012080456 hasAuthorship W2012080456A5051479554 @default.
- W2012080456 hasAuthorship W2012080456A5059823367 @default.
- W2012080456 hasConcept C105702510 @default.
- W2012080456 hasConcept C134018914 @default.
- W2012080456 hasConcept C170493617 @default.
- W2012080456 hasConcept C180361614 @default.
- W2012080456 hasConcept C2775960820 @default.
- W2012080456 hasConcept C2776362946 @default.
- W2012080456 hasConcept C2779335624 @default.
- W2012080456 hasConcept C2780550940 @default.
- W2012080456 hasConcept C2781294074 @default.
- W2012080456 hasConcept C2781403057 @default.
- W2012080456 hasConcept C54355233 @default.
- W2012080456 hasConcept C55493867 @default.
- W2012080456 hasConcept C74373430 @default.
- W2012080456 hasConcept C81885089 @default.
- W2012080456 hasConcept C86803240 @default.
- W2012080456 hasConcept C95444343 @default.
- W2012080456 hasConceptScore W2012080456C105702510 @default.
- W2012080456 hasConceptScore W2012080456C134018914 @default.
- W2012080456 hasConceptScore W2012080456C170493617 @default.
- W2012080456 hasConceptScore W2012080456C180361614 @default.
- W2012080456 hasConceptScore W2012080456C2775960820 @default.
- W2012080456 hasConceptScore W2012080456C2776362946 @default.
- W2012080456 hasConceptScore W2012080456C2779335624 @default.
- W2012080456 hasConceptScore W2012080456C2780550940 @default.
- W2012080456 hasConceptScore W2012080456C2781294074 @default.
- W2012080456 hasConceptScore W2012080456C2781403057 @default.
- W2012080456 hasConceptScore W2012080456C54355233 @default.
- W2012080456 hasConceptScore W2012080456C55493867 @default.
- W2012080456 hasConceptScore W2012080456C74373430 @default.
- W2012080456 hasConceptScore W2012080456C81885089 @default.
- W2012080456 hasConceptScore W2012080456C86803240 @default.
- W2012080456 hasConceptScore W2012080456C95444343 @default.
- W2012080456 hasIssue "2" @default.
- W2012080456 hasLocation W20120804561 @default.
- W2012080456 hasLocation W20120804562 @default.
- W2012080456 hasOpenAccess W2012080456 @default.
- W2012080456 hasPrimaryLocation W20120804561 @default.
- W2012080456 hasRelatedWork W1508300148 @default.
- W2012080456 hasRelatedWork W2019424555 @default.
- W2012080456 hasRelatedWork W2021910014 @default.
- W2012080456 hasRelatedWork W2036369536 @default.
- W2012080456 hasRelatedWork W2072054054 @default.
- W2012080456 hasRelatedWork W2079023278 @default.
- W2012080456 hasRelatedWork W2088172319 @default.
- W2012080456 hasRelatedWork W2129332981 @default.
- W2012080456 hasRelatedWork W2144324589 @default.
- W2012080456 hasRelatedWork W2091984663 @default.
- W2012080456 hasVolume "192" @default.
- W2012080456 isParatext "false" @default.
- W2012080456 isRetracted "false" @default.
- W2012080456 magId "2012080456" @default.
- W2012080456 workType "article" @default.