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- W2012080863 endingPage "9006" @default.
- W2012080863 startingPage "8993" @default.
- W2012080863 abstract "Macromolecular crowding is expected to have a significant effect on protein aggregation. In the present study we analyzed the effect of macromolecular crowding on fibrillation of four proteins, bovine S-carboxymethyl-alpha-lactalbumin (a disordered form of the protein with reduced three out of four disulfide bridges), human insulin, bovine core histones, and human alpha-synuclein. These proteins are structurally different, varying from natively unfolded (alpha-synuclein and core histones) to folded proteins with rigid tertiary and quaternary structures (monomeric and hexameric forms of insulin). All these proteins are known to fibrillate in diluted solutions, however their aggregation mechanisms are very divers and some of them are able to form different aggregates in addition to fibrils. We studied how macromolecular crowding guides protein between different aggregation pathways by analyzing the effect of crowding agents on the aggregation patterns under the variety of conditions favoring different aggregated end products in diluted solutions." @default.
- W2012080863 created "2016-06-24" @default.
- W2012080863 creator A5032345635 @default.
- W2012080863 creator A5061603180 @default.
- W2012080863 creator A5083199032 @default.
- W2012080863 creator A5083818614 @default.
- W2012080863 date "2008-07-30" @default.
- W2012080863 modified "2023-10-18" @default.
- W2012080863 title "Guiding Protein Aggregation with Macromolecular Crowding" @default.
- W2012080863 cites W1512176015 @default.
- W2012080863 cites W1527671059 @default.
- W2012080863 cites W1695118278 @default.
- W2012080863 cites W1709580310 @default.
- W2012080863 cites W1720678970 @default.
- W2012080863 cites W1806791563 @default.
- W2012080863 cites W1814457426 @default.
- W2012080863 cites W1970452781 @default.
- W2012080863 cites W1971087828 @default.
- W2012080863 cites W1975445752 @default.
- W2012080863 cites W1976488701 @default.
- W2012080863 cites W1984729685 @default.
- W2012080863 cites W1986250688 @default.
- W2012080863 cites W1986424517 @default.
- W2012080863 cites W1987898839 @default.
- W2012080863 cites W1988598575 @default.
- W2012080863 cites W1988949963 @default.
- W2012080863 cites W1989998882 @default.
- W2012080863 cites W1990622532 @default.
- W2012080863 cites W1991347541 @default.
- W2012080863 cites W1992067976 @default.
- W2012080863 cites W1992626528 @default.
- W2012080863 cites W1996798281 @default.
- W2012080863 cites W1998205923 @default.
- W2012080863 cites W1999092875 @default.
- W2012080863 cites W2000769077 @default.
- W2012080863 cites W2000943591 @default.
- W2012080863 cites W2001261348 @default.
- W2012080863 cites W2003744642 @default.
- W2012080863 cites W2003899611 @default.
- W2012080863 cites W2006654567 @default.
- W2012080863 cites W2007449704 @default.
- W2012080863 cites W2007717513 @default.
- W2012080863 cites W2008289288 @default.
- W2012080863 cites W2008827338 @default.
- W2012080863 cites W2009890105 @default.
- W2012080863 cites W2010048885 @default.
- W2012080863 cites W2010462701 @default.
- W2012080863 cites W2016429684 @default.
- W2012080863 cites W2017836578 @default.
- W2012080863 cites W2018380608 @default.
- W2012080863 cites W2018633688 @default.
- W2012080863 cites W2023245921 @default.
- W2012080863 cites W2023440735 @default.
- W2012080863 cites W2024148114 @default.
- W2012080863 cites W2029750840 @default.
- W2012080863 cites W2030045395 @default.
- W2012080863 cites W2033212454 @default.
- W2012080863 cites W2033829612 @default.
- W2012080863 cites W2034728705 @default.
- W2012080863 cites W2035057765 @default.
- W2012080863 cites W2037262444 @default.
- W2012080863 cites W2039792018 @default.
- W2012080863 cites W2042007687 @default.
- W2012080863 cites W2043350405 @default.
- W2012080863 cites W2043761562 @default.
- W2012080863 cites W2052474135 @default.
- W2012080863 cites W2053328000 @default.
- W2012080863 cites W2056324592 @default.
- W2012080863 cites W2058674503 @default.
- W2012080863 cites W2060872711 @default.
- W2012080863 cites W2064053352 @default.
- W2012080863 cites W2065492425 @default.
- W2012080863 cites W2071894993 @default.
- W2012080863 cites W2077044335 @default.
- W2012080863 cites W2078862798 @default.
- W2012080863 cites W2080751623 @default.
- W2012080863 cites W2085987859 @default.
- W2012080863 cites W2086926270 @default.
- W2012080863 cites W2088858313 @default.
- W2012080863 cites W2089082619 @default.
- W2012080863 cites W2090160047 @default.
- W2012080863 cites W2091265794 @default.
- W2012080863 cites W2092328911 @default.
- W2012080863 cites W2093221129 @default.
- W2012080863 cites W2096140548 @default.
- W2012080863 cites W2098004479 @default.
- W2012080863 cites W2110052787 @default.
- W2012080863 cites W2113312001 @default.
- W2012080863 cites W2114823344 @default.
- W2012080863 cites W2116890114 @default.
- W2012080863 cites W2119693327 @default.
- W2012080863 cites W2122802861 @default.
- W2012080863 cites W2123431154 @default.
- W2012080863 cites W2131187223 @default.
- W2012080863 cites W2134972813 @default.
- W2012080863 cites W2136617021 @default.
- W2012080863 cites W2140114637 @default.
- W2012080863 cites W2144339897 @default.