FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2012082077> ?p ?o ?g. }

• W2012082077 endingPage "662" @default.
• W2012082077 startingPage "659" @default.
• W2012082077 abstract "Recent work has demonstrated a correlation between frequency of aspirin ingestion and colorectal cancer prevention. Sulindac, another nonsteroidal anti-inflammatory drug (NSAID), has been shown to cause polyp regression and a fall in cell proliferation in patients with familial adenomatous polyposis, who are destined to develop colorectal cancer unless the colon is removed. However, the mode of action of NSAIDs in colorectal carcinogenesis prevention remains to be determined, although a prostaglandin-mediated mechanism seems likely.Rectal or duodenal biopsies from 20 patients with familial adenomatous polyposis, who had been randomized to sulindac or placebo, were analyzed for prostaglandin (PG) E2 and F2 alpha levels before and after treatment.A significant fall in prostaglandin E2 and F2 alpha levels was seen in patients who were on sulindac; this correlated with a visual improvement in number and size of polyps in the same patients (P = 0.0096; PGE2, P = 0.036; PGF2 alpha, Spearman's rank correlation).Nonsteroidal anti-inflammatory drugs may prevent colorectal cancer by their inhibition of prostaglandin synthesis. Prostaglandins may be implicated in carcinogenesis through an increase in cell proliferation, through immunosuppression, by increasing neovascularization, or via a mutagenic effect." @default.
• W2012082077 created "2016-06-24" @default.
• W2012082077 creator A5023928027 @default.
• W2012082077 creator A5025402904 @default.
• W2012082077 creator A5041248693 @default.
• W2012082077 date "1996-06-01" @default.
• W2012082077 modified "2023-09-23" @default.
• W2012082077 title "Tissue prostaglandin levels in familial adenomatous polyposis patients treated with sulindac" @default.
• W2012082077 cites W1511102453 @default.
• W2012082077 cites W1996715439 @default.
• W2012082077 cites W2009538335 @default.
• W2012082077 cites W2010425851 @default.
• W2012082077 cites W2023896274 @default.
• W2012082077 cites W2031652451 @default.
• W2012082077 cites W2035612792 @default.
• W2012082077 cites W2038889926 @default.
• W2012082077 cites W2039073493 @default.
• W2012082077 cites W2040060814 @default.
• W2012082077 cites W2047499066 @default.
• W2012082077 cites W2055951936 @default.
• W2012082077 cites W2058486668 @default.
• W2012082077 cites W2059689162 @default.
• W2012082077 cites W2081700576 @default.
• W2012082077 cites W2083380425 @default.
• W2012082077 cites W2110635352 @default.
• W2012082077 cites W2114589635 @default.
• W2012082077 cites W2129510413 @default.
• W2012082077 cites W2199203165 @default.
• W2012082077 cites W2308519941 @default.
• W2012082077 cites W2330709704 @default.
• W2012082077 cites W2340945640 @default.
• W2012082077 doi "https://doi.org/10.1007/bf02056946" @default.
• W2012082077 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8646953" @default.
• W2012082077 hasPublicationYear "1996" @default.
• W2012082077 type Work @default.
• W2012082077 sameAs 2012082077 @default.
• W2012082077 citedByCount "40" @default.
• W2012082077 countsByYear W20120820772013 @default.
• W2012082077 countsByYear W20120820772014 @default.
• W2012082077 countsByYear W20120820772020 @default.
• W2012082077 countsByYear W20120820772022 @default.
• W2012082077 crossrefType "journal-article" @default.
• W2012082077 hasAuthorship W2012082077A5023928027 @default.
• W2012082077 hasAuthorship W2012082077A5025402904 @default.
• W2012082077 hasAuthorship W2012082077A5041248693 @default.
• W2012082077 hasConcept C121608353 @default.
• W2012082077 hasConcept C126322002 @default.
• W2012082077 hasConcept C142724271 @default.
• W2012082077 hasConcept C143998085 @default.
• W2012082077 hasConcept C204787440 @default.
• W2012082077 hasConcept C27081682 @default.
• W2012082077 hasConcept C2776241388 @default.
• W2012082077 hasConcept C2777628954 @default.
• W2012082077 hasConcept C2777956040 @default.
• W2012082077 hasConcept C2778139025 @default.
• W2012082077 hasConcept C2778237340 @default.
• W2012082077 hasConcept C2778484676 @default.
• W2012082077 hasConcept C2780664492 @default.
• W2012082077 hasConcept C2780814781 @default.
• W2012082077 hasConcept C526805850 @default.
• W2012082077 hasConcept C71924100 @default.
• W2012082077 hasConcept C90924648 @default.
• W2012082077 hasConceptScore W2012082077C121608353 @default.
• W2012082077 hasConceptScore W2012082077C126322002 @default.
• W2012082077 hasConceptScore W2012082077C142724271 @default.
• W2012082077 hasConceptScore W2012082077C143998085 @default.
• W2012082077 hasConceptScore W2012082077C204787440 @default.
• W2012082077 hasConceptScore W2012082077C27081682 @default.
• W2012082077 hasConceptScore W2012082077C2776241388 @default.
• W2012082077 hasConceptScore W2012082077C2777628954 @default.
• W2012082077 hasConceptScore W2012082077C2777956040 @default.
• W2012082077 hasConceptScore W2012082077C2778139025 @default.
• W2012082077 hasConceptScore W2012082077C2778237340 @default.
• W2012082077 hasConceptScore W2012082077C2778484676 @default.
• W2012082077 hasConceptScore W2012082077C2780664492 @default.
• W2012082077 hasConceptScore W2012082077C2780814781 @default.
• W2012082077 hasConceptScore W2012082077C526805850 @default.
• W2012082077 hasConceptScore W2012082077C71924100 @default.
• W2012082077 hasConceptScore W2012082077C90924648 @default.
• W2012082077 hasIssue "6" @default.
• W2012082077 hasLocation W20120820771 @default.
• W2012082077 hasLocation W20120820772 @default.
• W2012082077 hasOpenAccess W2012082077 @default.
• W2012082077 hasPrimaryLocation W20120820771 @default.
• W2012082077 hasRelatedWork W2000429810 @default.
• W2012082077 hasRelatedWork W2012082077 @default.
• W2012082077 hasRelatedWork W2065406556 @default.
• W2012082077 hasRelatedWork W2093023732 @default.
• W2012082077 hasRelatedWork W2120723871 @default.
• W2012082077 hasRelatedWork W2165332825 @default.
• W2012082077 hasRelatedWork W2169682004 @default.
• W2012082077 hasRelatedWork W2528118601 @default.
• W2012082077 hasRelatedWork W2182509089 @default.
• W2012082077 hasRelatedWork W2277274488 @default.
• W2012082077 hasVolume "39" @default.
• W2012082077 isParatext "false" @default.
• W2012082077 isRetracted "false" @default.
• W2012082077 magId "2012082077" @default.

• next