FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2012085059> ?p ?o ?g. }

• W2012085059 endingPage "95" @default.
• W2012085059 startingPage "81" @default.
• W2012085059 abstract "Plasma fibronectin modulates reticuloendothelial (RE) phagocytosis of cellular and tissue debris, fibrin microaggregates, and gelatin-coated particulates. An antigenically related, but more insoluble form of fibronectin is found in various tissues and suspected to play a role in vascular permeability, cell adhesion, and wound healing. The current study developed a fluorescent immunoassay which could be utilized for the quantification of tissue fibronectin following its extraction from tissues. Additionally, the changes in tissue fibronectin induced by the intravenous injection of gelatin-coated colloids in rats (300–350 g), which acutely depletes the plasma fibronectin level, were also investigated. Injection of gelatinized RE test lipid emulsion (50 mg100 g) depleted the plasma fibronectin at 2 hr (80–85% depletion) followed by rebound restoration within 24 hr as quantified by either electroimmunoassay or fluorescent immunoassay. RES system clearance of the test particles from the blood resulted in an acute elevation in fibronectin extractable from the liver with a normalization by 48 hr. In contrast, assay of tissue fibronectin following a single extraction revealed a decrease in lung extractable fibronectin within 2 hr following RE blockade which persisted for 24–48 hr. Extractable fibronectin in spleen and renal tissue was unaltered by RE blockade. This microfluorescent immunoassay may provide a sensitive method to quantify fibronectin in small aliquots of tissue. Increased hepatic fibronectin most likely reflects interiorization of plasma fibronectin during Kupffer cell clearance of the test particles. Decreased lung extractable fibronectin may alter lung vascular sensitivity to a subsequent septic and/or intravascular coagulation stress. Thus, similar to the labile nature of plasma fibronectin, the concentration of fibronectin in various tissues, can undergo dynamic alterations." @default.
• W2012085059 created "2016-06-24" @default.
• W2012085059 creator A5006114730 @default.
• W2012085059 creator A5037703738 @default.
• W2012085059 creator A5091336789 @default.
• W2012085059 date "1984-08-01" @default.
• W2012085059 modified "2023-09-23" @default.
• W2012085059 title "Effect of acute plasma fibronectin depletion on tissue fibronectin levels: Analysis by a new fluorescent immunoassay" @default.
• W2012085059 cites W1488171851 @default.
• W2012085059 cites W1550118454 @default.
• W2012085059 cites W1828578349 @default.
• W2012085059 cites W1895482058 @default.
• W2012085059 cites W1993104510 @default.
• W2012085059 cites W1993582348 @default.
• W2012085059 cites W1994408107 @default.
• W2012085059 cites W2020511578 @default.
• W2012085059 cites W2024373128 @default.
• W2012085059 cites W2026641817 @default.
• W2012085059 cites W2033416896 @default.
• W2012085059 cites W2055589291 @default.
• W2012085059 cites W2056468589 @default.
• W2012085059 cites W2065610663 @default.
• W2012085059 cites W2065948470 @default.
• W2012085059 cites W2078278323 @default.
• W2012085059 cites W2082688835 @default.
• W2012085059 cites W2085931309 @default.
• W2012085059 cites W2091519770 @default.
• W2012085059 cites W2099054210 @default.
• W2012085059 cites W2109272101 @default.
• W2012085059 cites W2139084649 @default.
• W2012085059 cites W2147546487 @default.
• W2012085059 cites W2269433666 @default.
• W2012085059 cites W2465216279 @default.
• W2012085059 cites W82180823 @default.
• W2012085059 doi "https://doi.org/10.1016/0014-4800(84)90010-8" @default.
• W2012085059 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/6381090" @default.
• W2012085059 hasPublicationYear "1984" @default.
• W2012085059 type Work @default.
• W2012085059 sameAs 2012085059 @default.
• W2012085059 citedByCount "7" @default.
• W2012085059 crossrefType "journal-article" @default.
• W2012085059 hasAuthorship W2012085059A5006114730 @default.
• W2012085059 hasAuthorship W2012085059A5037703738 @default.
• W2012085059 hasAuthorship W2012085059A5091336789 @default.
• W2012085059 hasConcept C142724271 @default.
• W2012085059 hasConcept C153911025 @default.
• W2012085059 hasConcept C159654299 @default.
• W2012085059 hasConcept C160448771 @default.
• W2012085059 hasConcept C185592680 @default.
• W2012085059 hasConcept C189165786 @default.
• W2012085059 hasConcept C203014093 @default.
• W2012085059 hasConcept C2780420688 @default.
• W2012085059 hasConcept C2780931953 @default.
• W2012085059 hasConcept C54173615 @default.
• W2012085059 hasConcept C55493867 @default.
• W2012085059 hasConcept C71924100 @default.
• W2012085059 hasConcept C86492073 @default.
• W2012085059 hasConcept C86803240 @default.
• W2012085059 hasConceptScore W2012085059C142724271 @default.
• W2012085059 hasConceptScore W2012085059C153911025 @default.
• W2012085059 hasConceptScore W2012085059C159654299 @default.
• W2012085059 hasConceptScore W2012085059C160448771 @default.
• W2012085059 hasConceptScore W2012085059C185592680 @default.
• W2012085059 hasConceptScore W2012085059C189165786 @default.
• W2012085059 hasConceptScore W2012085059C203014093 @default.
• W2012085059 hasConceptScore W2012085059C2780420688 @default.
• W2012085059 hasConceptScore W2012085059C2780931953 @default.
• W2012085059 hasConceptScore W2012085059C54173615 @default.
• W2012085059 hasConceptScore W2012085059C55493867 @default.
• W2012085059 hasConceptScore W2012085059C71924100 @default.
• W2012085059 hasConceptScore W2012085059C86492073 @default.
• W2012085059 hasConceptScore W2012085059C86803240 @default.
• W2012085059 hasIssue "1" @default.
• W2012085059 hasLocation W20120850591 @default.
• W2012085059 hasLocation W20120850592 @default.
• W2012085059 hasOpenAccess W2012085059 @default.
• W2012085059 hasPrimaryLocation W20120850591 @default.
• W2012085059 hasRelatedWork W1960988955 @default.
• W2012085059 hasRelatedWork W1965405950 @default.
• W2012085059 hasRelatedWork W1996631463 @default.
• W2012085059 hasRelatedWork W2063887023 @default.
• W2012085059 hasRelatedWork W2068324201 @default.
• W2012085059 hasRelatedWork W2312945484 @default.
• W2012085059 hasRelatedWork W2334477084 @default.
• W2012085059 hasRelatedWork W2397837283 @default.
• W2012085059 hasRelatedWork W2415610735 @default.
• W2012085059 hasRelatedWork W2470623763 @default.
• W2012085059 hasVolume "41" @default.
• W2012085059 isParatext "false" @default.
• W2012085059 isRetracted "false" @default.
• W2012085059 magId "2012085059" @default.
• W2012085059 workType "article" @default.