Matches in SemOpenAlex for { <https://semopenalex.org/work/W2012085812> ?p ?o ?g. }
- W2012085812 endingPage "143" @default.
- W2012085812 startingPage "133" @default.
- W2012085812 abstract "Clathrin-mediated vesicle recycling in synapses is maintained by a unique set of endocytic proteins and interactions. We show that endophilin localizes in the vesicle pool at rest and in spirals at the necks of clathrin-coated pits (CCPs) during activity in lamprey synapses. Endophilin and dynamin colocalize at the base of the clathrin coat. Protein spirals composed of these proteins on lipid tubes in vitro have a pitch similar to the one observed at necks of CCPs in living synapses, and lipid tubules are thinner than those formed by dynamin alone. Tubulation efficiency and the amount of dynamin recruited to lipid tubes are dramatically increased in the presence of endophilin. Blocking the interactions of the endophilin SH3 domain in situ reduces dynamin accumulation at the neck and prevents the formation of elongated necks observed in the presence of GTPγS. Therefore, endophilin recruits dynamin to a restricted part of the CCP neck, forming a complex, which promotes budding of new synaptic vesicles." @default.
- W2012085812 created "2016-06-24" @default.
- W2012085812 creator A5024219521 @default.
- W2012085812 creator A5033396109 @default.
- W2012085812 creator A5037492526 @default.
- W2012085812 creator A5053581463 @default.
- W2012085812 creator A5068346610 @default.
- W2012085812 creator A5068703722 @default.
- W2012085812 date "2011-01-01" @default.
- W2012085812 modified "2023-10-01" @default.
- W2012085812 title "An endophilin–dynamin complex promotes budding of clathrin-coated vesicles during synaptic vesicle recycling" @default.
- W2012085812 cites W1533663659 @default.
- W2012085812 cites W1965940344 @default.
- W2012085812 cites W1969473585 @default.
- W2012085812 cites W1970831436 @default.
- W2012085812 cites W1980143055 @default.
- W2012085812 cites W1983843391 @default.
- W2012085812 cites W1985685023 @default.
- W2012085812 cites W1989894857 @default.
- W2012085812 cites W1994332160 @default.
- W2012085812 cites W1999679029 @default.
- W2012085812 cites W2010136703 @default.
- W2012085812 cites W2013348217 @default.
- W2012085812 cites W2019040974 @default.
- W2012085812 cites W2025134925 @default.
- W2012085812 cites W2026064702 @default.
- W2012085812 cites W2033021180 @default.
- W2012085812 cites W2033395544 @default.
- W2012085812 cites W2050304765 @default.
- W2012085812 cites W2055555352 @default.
- W2012085812 cites W2067359176 @default.
- W2012085812 cites W2071877471 @default.
- W2012085812 cites W2079900215 @default.
- W2012085812 cites W2079981145 @default.
- W2012085812 cites W2087061911 @default.
- W2012085812 cites W2100869615 @default.
- W2012085812 cites W2115654142 @default.
- W2012085812 cites W2117649547 @default.
- W2012085812 cites W2130580181 @default.
- W2012085812 cites W2135194969 @default.
- W2012085812 cites W2139943177 @default.
- W2012085812 cites W2143898087 @default.
- W2012085812 cites W2166348969 @default.
- W2012085812 cites W2166439771 @default.
- W2012085812 cites W2167511682 @default.
- W2012085812 cites W51728322 @default.
- W2012085812 doi "https://doi.org/10.1242/jcs.072686" @default.
- W2012085812 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3001412" @default.
- W2012085812 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21172823" @default.
- W2012085812 hasPublicationYear "2011" @default.
- W2012085812 type Work @default.
- W2012085812 sameAs 2012085812 @default.
- W2012085812 citedByCount "104" @default.
- W2012085812 countsByYear W20120858122012 @default.
- W2012085812 countsByYear W20120858122013 @default.
- W2012085812 countsByYear W20120858122014 @default.
- W2012085812 countsByYear W20120858122015 @default.
- W2012085812 countsByYear W20120858122016 @default.
- W2012085812 countsByYear W20120858122017 @default.
- W2012085812 countsByYear W20120858122018 @default.
- W2012085812 countsByYear W20120858122019 @default.
- W2012085812 countsByYear W20120858122020 @default.
- W2012085812 countsByYear W20120858122021 @default.
- W2012085812 countsByYear W20120858122022 @default.
- W2012085812 countsByYear W20120858122023 @default.
- W2012085812 crossrefType "journal-article" @default.
- W2012085812 hasAuthorship W2012085812A5024219521 @default.
- W2012085812 hasAuthorship W2012085812A5033396109 @default.
- W2012085812 hasAuthorship W2012085812A5037492526 @default.
- W2012085812 hasAuthorship W2012085812A5053581463 @default.
- W2012085812 hasAuthorship W2012085812A5068346610 @default.
- W2012085812 hasAuthorship W2012085812A5068703722 @default.
- W2012085812 hasBestOaLocation W20120858122 @default.
- W2012085812 hasConcept C12554922 @default.
- W2012085812 hasConcept C130316041 @default.
- W2012085812 hasConcept C148785051 @default.
- W2012085812 hasConcept C156407911 @default.
- W2012085812 hasConcept C170493617 @default.
- W2012085812 hasConcept C198410946 @default.
- W2012085812 hasConcept C28005876 @default.
- W2012085812 hasConcept C2908668639 @default.
- W2012085812 hasConcept C41625074 @default.
- W2012085812 hasConcept C55493867 @default.
- W2012085812 hasConcept C63162447 @default.
- W2012085812 hasConcept C79747257 @default.
- W2012085812 hasConcept C86803240 @default.
- W2012085812 hasConcept C95444343 @default.
- W2012085812 hasConceptScore W2012085812C12554922 @default.
- W2012085812 hasConceptScore W2012085812C130316041 @default.
- W2012085812 hasConceptScore W2012085812C148785051 @default.
- W2012085812 hasConceptScore W2012085812C156407911 @default.
- W2012085812 hasConceptScore W2012085812C170493617 @default.
- W2012085812 hasConceptScore W2012085812C198410946 @default.
- W2012085812 hasConceptScore W2012085812C28005876 @default.
- W2012085812 hasConceptScore W2012085812C2908668639 @default.
- W2012085812 hasConceptScore W2012085812C41625074 @default.
- W2012085812 hasConceptScore W2012085812C55493867 @default.
- W2012085812 hasConceptScore W2012085812C63162447 @default.