Matches in SemOpenAlex for { <https://semopenalex.org/work/W2012086777> ?p ?o ?g. }
- W2012086777 endingPage "262" @default.
- W2012086777 startingPage "250" @default.
- W2012086777 abstract "Terminal differentiation of oligodendrocytes is associated with permanent withdrawal from the cell cycle. We studied the expression of the retinoblastoma protein, expression and activity of G1 cyclins and kinases in oligodendrocyte progenitor cells cultured in vitro. We found that Rb stopped to be expressed concomitantly with the activation of CNPase in oligodendrocytes differentiated with thyroid hormone. In contrast, Rb continued to be expressed at reduced levels in oligodendrocytes that were arrested in G1 by removal of mitogens. Cyclin D1, cdk2, and cdk4 kinase activities were decreased in G1-arrested and differentiated oligodendrocytes. Cyclin E, however, continued to be expressed in G1-arrested oligodendrocytes. Inhibition of differentiation induced by mitogens in oligodendrocytes arrested in G1 by Ad-p27 was accompanied by continued expression of Rb, D1, and E cyclins. After removal of mitogens and addition of thyroid hormone, Rb stopped being expressed and CNPase expression was activated with a temporal course similar to that of oligodendrocytes infected with a control adenovirus. Our results indicate that Rb may play an important function in differentiation of oligodendrocytes in response to external mitogens and differentiation factors." @default.
- W2012086777 created "2016-06-24" @default.
- W2012086777 creator A5001557633 @default.
- W2012086777 creator A5057361257 @default.
- W2012086777 creator A5061217486 @default.
- W2012086777 date "2002-02-01" @default.
- W2012086777 modified "2023-10-16" @default.
- W2012086777 title "Down-Regulation of the Retinoblastoma Protein (Rb) Is Associated with Rat Oligodendrocyte Differentiation" @default.
- W2012086777 cites W1497961594 @default.
- W2012086777 cites W1851939116 @default.
- W2012086777 cites W1900556344 @default.
- W2012086777 cites W1939346623 @default.
- W2012086777 cites W1963550744 @default.
- W2012086777 cites W1972524334 @default.
- W2012086777 cites W1974092339 @default.
- W2012086777 cites W1981283223 @default.
- W2012086777 cites W1986249155 @default.
- W2012086777 cites W1986420581 @default.
- W2012086777 cites W1989382065 @default.
- W2012086777 cites W1990200645 @default.
- W2012086777 cites W1990925999 @default.
- W2012086777 cites W1991832674 @default.
- W2012086777 cites W1992172737 @default.
- W2012086777 cites W1992245559 @default.
- W2012086777 cites W1992762478 @default.
- W2012086777 cites W1993618034 @default.
- W2012086777 cites W1998329265 @default.
- W2012086777 cites W1999330214 @default.
- W2012086777 cites W2004332335 @default.
- W2012086777 cites W2011557383 @default.
- W2012086777 cites W2015066175 @default.
- W2012086777 cites W2021334422 @default.
- W2012086777 cites W2027983444 @default.
- W2012086777 cites W2030126982 @default.
- W2012086777 cites W2033939933 @default.
- W2012086777 cites W2036518710 @default.
- W2012086777 cites W2036567890 @default.
- W2012086777 cites W2038846947 @default.
- W2012086777 cites W2051541258 @default.
- W2012086777 cites W2052651806 @default.
- W2012086777 cites W2058119565 @default.
- W2012086777 cites W2062522473 @default.
- W2012086777 cites W2066257477 @default.
- W2012086777 cites W2079091610 @default.
- W2012086777 cites W2085087860 @default.
- W2012086777 cites W2085593164 @default.
- W2012086777 cites W2088591814 @default.
- W2012086777 cites W2090289340 @default.
- W2012086777 cites W2092589801 @default.
- W2012086777 cites W2099082103 @default.
- W2012086777 cites W2105105956 @default.
- W2012086777 cites W2111600528 @default.
- W2012086777 cites W2114389372 @default.
- W2012086777 cites W2115692032 @default.
- W2012086777 cites W2127237580 @default.
- W2012086777 cites W2134331780 @default.
- W2012086777 cites W2137165110 @default.
- W2012086777 cites W2146636701 @default.
- W2012086777 cites W2149164963 @default.
- W2012086777 cites W2165240249 @default.
- W2012086777 cites W2167229704 @default.
- W2012086777 cites W2187173242 @default.
- W2012086777 cites W2188070684 @default.
- W2012086777 cites W2323387578 @default.
- W2012086777 cites W4253508985 @default.
- W2012086777 cites W4301760855 @default.
- W2012086777 doi "https://doi.org/10.1006/mcne.2001.1077" @default.
- W2012086777 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11860277" @default.
- W2012086777 hasPublicationYear "2002" @default.
- W2012086777 type Work @default.
- W2012086777 sameAs 2012086777 @default.
- W2012086777 citedByCount "31" @default.
- W2012086777 countsByYear W20120867772012 @default.
- W2012086777 countsByYear W20120867772014 @default.
- W2012086777 countsByYear W20120867772016 @default.
- W2012086777 countsByYear W20120867772017 @default.
- W2012086777 countsByYear W20120867772019 @default.
- W2012086777 countsByYear W20120867772020 @default.
- W2012086777 countsByYear W20120867772021 @default.
- W2012086777 crossrefType "journal-article" @default.
- W2012086777 hasAuthorship W2012086777A5001557633 @default.
- W2012086777 hasAuthorship W2012086777A5057361257 @default.
- W2012086777 hasAuthorship W2012086777A5061217486 @default.
- W2012086777 hasConcept C104317684 @default.
- W2012086777 hasConcept C120089663 @default.
- W2012086777 hasConcept C134018914 @default.
- W2012086777 hasConcept C148738053 @default.
- W2012086777 hasConcept C1491633281 @default.
- W2012086777 hasConcept C184235292 @default.
- W2012086777 hasConcept C199835354 @default.
- W2012086777 hasConcept C2776062698 @default.
- W2012086777 hasConcept C2776577112 @default.
- W2012086777 hasConcept C2776985911 @default.
- W2012086777 hasConcept C2778609137 @default.
- W2012086777 hasConcept C29537977 @default.
- W2012086777 hasConcept C529278444 @default.
- W2012086777 hasConcept C55493867 @default.
- W2012086777 hasConcept C86803240 @default.