Matches in SemOpenAlex for { <https://semopenalex.org/work/W2012086961> ?p ?o ?g. }
- W2012086961 endingPage "871" @default.
- W2012086961 startingPage "871" @default.
- W2012086961 abstract "Polyketides (PKs) are a class of natural products with highly diverse structures and bioactivities. Important clinical antibiotics like tetracycline, erythromycin, mupirocin, and dalfopristin (a component of Synercid®) belong to this compound class. The diversity of PK structures depends on their assembly process, for which multifunctional enzymes, the modular polyketide synthases (PKSs), are required. These megasynthases are organized in modules, consisting of integrated enzymatic domains, which catalyze the individual reaction steps in PK biosynthesis. Here, we focus on a subset of PKSs, the trans-AT type modular PKSs and their discrete acyltransferases (ATs). In contrast to the classical cis-AT PKSs which have AT domains within the megasynthases, the trans-AT PKSs recruit discrete ATs, which are encoded by separate genes. ATs are required for the selection of precursors and their loading to acyl carrier protein (ACP) domains of the PKS. Although, the number of identified trans-AT PKS gene clusters increased over the last decade, the functional analysis of the discrete ATs in those pathways was carried out only for a few examples. In these cases – excluding ATs accepting ACP-linked extenders – transfer of malonyl-CoA was observed. This suggested a strict malonyl-CoA specificity of the in trans acting ATs. Only recently, a discrete AT, which selects freestanding ethylmalonyl-CoA and uses this substrate for the direct loading of a specific ACP domain of a kirromycin PKS, was described. Furthermore, this represents a novel mechanism of incorporation of branched structures into polyketides. The identification of the AT motifs responsible for the substrate recognition and ACP docking are of particular importance for understanding and modification of such systems. Here, we provide a summary of information gained from experimental studies on discrete ATs involved in polyketide biosynthesis until the end of 2011." @default.
- W2012086961 created "2016-06-24" @default.
- W2012086961 creator A5072329060 @default.
- W2012086961 creator A5086274481 @default.
- W2012086961 date "2012-01-01" @default.
- W2012086961 modified "2023-09-26" @default.
- W2012086961 title "Discrete acyltransferases involved in polyketide biosynthesis" @default.
- W2012086961 cites W133422227 @default.
- W2012086961 cites W1492914770 @default.
- W2012086961 cites W1499436602 @default.
- W2012086961 cites W1536211123 @default.
- W2012086961 cites W1547054036 @default.
- W2012086961 cites W1844278134 @default.
- W2012086961 cites W1906022976 @default.
- W2012086961 cites W1913554254 @default.
- W2012086961 cites W1963566065 @default.
- W2012086961 cites W1964926058 @default.
- W2012086961 cites W1965532584 @default.
- W2012086961 cites W1966664751 @default.
- W2012086961 cites W1967397050 @default.
- W2012086961 cites W1967645465 @default.
- W2012086961 cites W1968670526 @default.
- W2012086961 cites W1972337385 @default.
- W2012086961 cites W1973124483 @default.
- W2012086961 cites W1973421302 @default.
- W2012086961 cites W1974191073 @default.
- W2012086961 cites W1974755668 @default.
- W2012086961 cites W1975494987 @default.
- W2012086961 cites W1977263994 @default.
- W2012086961 cites W1978418188 @default.
- W2012086961 cites W1979298568 @default.
- W2012086961 cites W1982580806 @default.
- W2012086961 cites W1982793579 @default.
- W2012086961 cites W1985262327 @default.
- W2012086961 cites W1985723784 @default.
- W2012086961 cites W1985972344 @default.
- W2012086961 cites W1988369885 @default.
- W2012086961 cites W1988643982 @default.
- W2012086961 cites W1988948560 @default.
- W2012086961 cites W1989467069 @default.
- W2012086961 cites W1990461957 @default.
- W2012086961 cites W1994380180 @default.
- W2012086961 cites W1995120858 @default.
- W2012086961 cites W1995241750 @default.
- W2012086961 cites W1998498230 @default.
- W2012086961 cites W1999944965 @default.
- W2012086961 cites W2001827734 @default.
- W2012086961 cites W2003047055 @default.
- W2012086961 cites W2004050482 @default.
- W2012086961 cites W2004470352 @default.
- W2012086961 cites W2004481736 @default.
- W2012086961 cites W2005679878 @default.
- W2012086961 cites W2007318690 @default.
- W2012086961 cites W2007483319 @default.
- W2012086961 cites W2008912752 @default.
- W2012086961 cites W2010371815 @default.
- W2012086961 cites W2011757239 @default.
- W2012086961 cites W2013310372 @default.
- W2012086961 cites W2014197955 @default.
- W2012086961 cites W2017572508 @default.
- W2012086961 cites W2017739927 @default.
- W2012086961 cites W2018658509 @default.
- W2012086961 cites W2019109037 @default.
- W2012086961 cites W2020382107 @default.
- W2012086961 cites W2021231007 @default.
- W2012086961 cites W2022011257 @default.
- W2012086961 cites W2023380434 @default.
- W2012086961 cites W2024170763 @default.
- W2012086961 cites W2025106895 @default.
- W2012086961 cites W2025203284 @default.
- W2012086961 cites W2026399160 @default.
- W2012086961 cites W2029242612 @default.
- W2012086961 cites W2030374422 @default.
- W2012086961 cites W2030431481 @default.
- W2012086961 cites W2031162742 @default.
- W2012086961 cites W2031326137 @default.
- W2012086961 cites W2032283958 @default.
- W2012086961 cites W2032292596 @default.
- W2012086961 cites W2034383954 @default.
- W2012086961 cites W2035020496 @default.
- W2012086961 cites W2036080658 @default.
- W2012086961 cites W2037016546 @default.
- W2012086961 cites W2038299797 @default.
- W2012086961 cites W2038422272 @default.
- W2012086961 cites W2039285595 @default.
- W2012086961 cites W2042283097 @default.
- W2012086961 cites W2043364538 @default.
- W2012086961 cites W2043689147 @default.
- W2012086961 cites W2046006818 @default.
- W2012086961 cites W2046197352 @default.
- W2012086961 cites W2046907677 @default.
- W2012086961 cites W2047100123 @default.
- W2012086961 cites W2049522349 @default.
- W2012086961 cites W2051397923 @default.
- W2012086961 cites W2051844246 @default.
- W2012086961 cites W2052659638 @default.
- W2012086961 cites W2054302957 @default.
- W2012086961 cites W2055767424 @default.