FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2012087989> ?p ?o ?g. }

• W2012087989 endingPage "608" @default.
• W2012087989 startingPage "601" @default.
• W2012087989 abstract "Beef insulin, pork proinsulin and four derivatives of beef insulin modified at the A1-B29 site on the molecular surface have been studied. Three derivatives had a synthetic crosslink between the A and B chains. Previous studies with these materials [2, 3 and 5] had demonstrated in vivo bioactivities which were much higher than those displayed in vitro. This paper reports experiments which explain this discrepancy. The analogues were administered at equimolar rates to anaesthetised greyhounds by a priming-dose constant infusion technique and the plasma concentrations achieved were estimated by radioimmunoassay. Proinsulin and the modified insulins were metabolised more slowly than insulin. Biopotency values, which related fall in plasma glucose concentration to the total administered dose of analogue, agreed broadly with published results of conventional in vivo bioassays. On the other hand, calculation of potency in relation to the serum concentration of analogue actually achieved, yielded results which agreed more closely with in vitro assay data. We conclude that for these analogues, reported discrepancies between in vitro and in vivo biopotencies can be largely explained by the different rates at which these materials are metabolised." @default.
• W2012087989 created "2016-06-24" @default.
• W2012087989 creator A5024831104 @default.
• W2012087989 creator A5041781177 @default.
• W2012087989 creator A5046297999 @default.
• W2012087989 creator A5046769127 @default.
• W2012087989 creator A5056674673 @default.
• W2012087989 date "1976-12-01" @default.
• W2012087989 modified "2023-10-16" @default.
• W2012087989 title "Biological properties of chemically modified insulins. I. Biological activity of proinsulin and insulin modified at A1-glycine and B29-lysine" @default.
• W2012087989 cites W1487462613 @default.
• W2012087989 cites W1587305227 @default.
• W2012087989 cites W1605939661 @default.
• W2012087989 cites W1893651774 @default.
• W2012087989 cites W1924025063 @default.
• W2012087989 cites W1999222278 @default.
• W2012087989 cites W2005228679 @default.
• W2012087989 cites W2029790191 @default.
• W2012087989 cites W2039242258 @default.
• W2012087989 cites W2046152615 @default.
• W2012087989 cites W2053311112 @default.
• W2012087989 cites W2064134818 @default.
• W2012087989 cites W2086739116 @default.
• W2012087989 cites W2210714950 @default.
• W2012087989 cites W226547484 @default.
• W2012087989 cites W2321499021 @default.
• W2012087989 cites W2416424592 @default.
• W2012087989 cites W2432962991 @default.
• W2012087989 cites W2913152705 @default.
• W2012087989 cites W2992362329 @default.
• W2012087989 cites W331502463 @default.
• W2012087989 cites W964503500 @default.
• W2012087989 doi "https://doi.org/10.1007/bf01220637" @default.
• W2012087989 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1001848" @default.
• W2012087989 hasPublicationYear "1976" @default.
• W2012087989 type Work @default.
• W2012087989 sameAs 2012087989 @default.
• W2012087989 citedByCount "31" @default.
• W2012087989 countsByYear W20120879892012 @default.
• W2012087989 countsByYear W20120879892013 @default.
• W2012087989 countsByYear W20120879892016 @default.
• W2012087989 crossrefType "journal-article" @default.
• W2012087989 hasAuthorship W2012087989A5024831104 @default.
• W2012087989 hasAuthorship W2012087989A5041781177 @default.
• W2012087989 hasAuthorship W2012087989A5046297999 @default.
• W2012087989 hasAuthorship W2012087989A5046769127 @default.
• W2012087989 hasAuthorship W2012087989A5056674673 @default.
• W2012087989 hasBestOaLocation W20120879891 @default.
• W2012087989 hasConcept C104488531 @default.
• W2012087989 hasConcept C116073593 @default.
• W2012087989 hasConcept C126322002 @default.
• W2012087989 hasConcept C134018914 @default.
• W2012087989 hasConcept C150903083 @default.
• W2012087989 hasConcept C176685330 @default.
• W2012087989 hasConcept C185592680 @default.
• W2012087989 hasConcept C202751555 @default.
• W2012087989 hasConcept C207001950 @default.
• W2012087989 hasConcept C2777756961 @default.
• W2012087989 hasConcept C2779306644 @default.
• W2012087989 hasConcept C515207424 @default.
• W2012087989 hasConcept C54355233 @default.
• W2012087989 hasConcept C55493867 @default.
• W2012087989 hasConcept C57992300 @default.
• W2012087989 hasConcept C71924100 @default.
• W2012087989 hasConcept C86803240 @default.
• W2012087989 hasConcept C90061646 @default.
• W2012087989 hasConcept C98274493 @default.
• W2012087989 hasConceptScore W2012087989C104488531 @default.
• W2012087989 hasConceptScore W2012087989C116073593 @default.
• W2012087989 hasConceptScore W2012087989C126322002 @default.
• W2012087989 hasConceptScore W2012087989C134018914 @default.
• W2012087989 hasConceptScore W2012087989C150903083 @default.
• W2012087989 hasConceptScore W2012087989C176685330 @default.
• W2012087989 hasConceptScore W2012087989C185592680 @default.
• W2012087989 hasConceptScore W2012087989C202751555 @default.
• W2012087989 hasConceptScore W2012087989C207001950 @default.
• W2012087989 hasConceptScore W2012087989C2777756961 @default.
• W2012087989 hasConceptScore W2012087989C2779306644 @default.
• W2012087989 hasConceptScore W2012087989C515207424 @default.
• W2012087989 hasConceptScore W2012087989C54355233 @default.
• W2012087989 hasConceptScore W2012087989C55493867 @default.
• W2012087989 hasConceptScore W2012087989C57992300 @default.
• W2012087989 hasConceptScore W2012087989C71924100 @default.
• W2012087989 hasConceptScore W2012087989C86803240 @default.
• W2012087989 hasConceptScore W2012087989C90061646 @default.
• W2012087989 hasConceptScore W2012087989C98274493 @default.
• W2012087989 hasIssue "6" @default.
• W2012087989 hasLocation W20120879891 @default.
• W2012087989 hasLocation W20120879892 @default.
• W2012087989 hasOpenAccess W2012087989 @default.
• W2012087989 hasPrimaryLocation W20120879891 @default.
• W2012087989 hasRelatedWork W1997039251 @default.
• W2012087989 hasRelatedWork W2030768859 @default.
• W2012087989 hasRelatedWork W2039992937 @default.
• W2012087989 hasRelatedWork W2064751303 @default.
• W2012087989 hasRelatedWork W2072014172 @default.
• W2012087989 hasRelatedWork W2079112323 @default.
• W2012087989 hasRelatedWork W2113905390 @default.

• next