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• W2012088448 abstract "In the present study we have investigated the mechanisms of pulmonary edema caused by platelet-activating factor (PAF) in isolated rat lungs as well as in mice in vivo. In blood-free perfused and ventilated rat lungs, PAF increased lung weight by 0.59 ± 0.18 g. The cyclooxygenase inhibitor aspirin (500 μ M) blocked this response by one-third, and the quinolines quinine (330 μ M), quinidine (100 μ M), and chloroquine (100 μ M) by two-thirds. Lipoxygenase inhibition (10 μ M AA861) alone or in combination with thromboxane receptor antagonism (10 μ M SQ29548) had no effect on PAF-induced weight gain. In combination with aspirin, quinine or quinidine completely prevented PAF-induced weight gain and the concomitant increase of the capillary filtration coefficient (Kf,c). Pretreatment with quinine in vivo prevented not only PAF-, but also endotoxin-induced edema formation as assessed by Evans Blue extravasation. In addition, in vivo quinine prevented the endotoxin-induced release of tumor neurosis factor (TNF). Furthermore, in perfused lungs quinine reduced the PAF-induced increases in airway and vascular resistance, as well as thromboxane release. These findings demonstrate the following anti-inflammatory properties of quinolines: reduction of thromboxane and TNF formation; reduction of PAF-induced vasoconstriction and bronchoconstriction; and attenuation of PAF- and lipopolysaccharide (LPS)-induced edema formation. We conclude that the PAF- induced edema consists of two separate mechanisms, one dependent on an unknown cyclooxygenase metabolite, the other one sensitive to quinolines. Falk S, Göggel R, Heydasch U, Brasch F, Müller K-M, Wendel A, Uhlig S. Quinolines attenuate PAF-induced pulmonary pressor responses and edema formation." @default.
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• W2012088448 date "1999-11-01" @default.
• W2012088448 modified "2023-10-17" @default.
• W2012088448 title "Quinolines Attenuate PAF-induced Pulmonary Pressor Responses and Edema Formation" @default.
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• W2012088448 doi "https://doi.org/10.1164/ajrccm.160.5.9902033" @default.
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