FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2012088617> ?p ?o ?g. }

• W2012088617 endingPage "e1003293" @default.
• W2012088617 startingPage "e1003293" @default.
• W2012088617 abstract "The IL-27R, WSX-1, is required to limit IFN-γ production by effector CD4⁺ T cells in a number of different inflammatory conditions but the molecular basis of WSX-1-mediated regulation of Th1 responses in vivo during infection has not been investigated in detail. In this study we demonstrate that WSX-1 signalling suppresses the development of pathogenic, terminally differentiated (KLRG-1⁺) Th1 cells during malaria infection and establishes a restrictive threshold to constrain the emergent Th1 response. Importantly, we show that WSX-1 regulates cell-intrinsic responsiveness to IL-12 and IL-2, but the fate of the effector CD4⁺ T cell pool during malaria infection is controlled primarily through IL-12 dependent signals. Finally, we show that WSX-1 regulates Th1 cell terminal differentiation during malaria infection through IL-10 and Foxp3 independent mechanisms; the kinetics and magnitude of the Th1 response, and the degree of Th1 cell terminal differentiation, were comparable in WT, IL-10R1⁻/⁻ and IL-10⁻/⁻ mice and the numbers and phenotype of Foxp3⁺ cells were largely unaltered in WSX-1⁻/⁻ mice during infection. As expected, depletion of Foxp3⁺ cells did not enhance Th1 cell polarisation or terminal differentiation during malaria infection. Our results significantly expand our understanding of how IL-27 regulates Th1 responses in vivo during inflammatory conditions and establishes WSX-1 as a critical and non-redundant regulator of the emergent Th1 effector response during malaria infection." @default.
• W2012088617 created "2016-06-24" @default.
• W2012088617 creator A5003951398 @default.
• W2012088617 creator A5008502588 @default.
• W2012088617 creator A5017348677 @default.
• W2012088617 creator A5038289225 @default.
• W2012088617 creator A5040066221 @default.
• W2012088617 creator A5052599084 @default.
• W2012088617 creator A5075407171 @default.
• W2012088617 creator A5079003683 @default.
• W2012088617 creator A5088453567 @default.
• W2012088617 creator A5091769869 @default.
• W2012088617 date "2013-04-11" @default.
• W2012088617 modified "2023-10-18" @default.
• W2012088617 title "IL-27 Receptor Signalling Restricts the Formation of Pathogenic, Terminally Differentiated Th1 Cells during Malaria Infection by Repressing IL-12 Dependent Signals" @default.
• W2012088617 cites W1530794261 @default.
• W2012088617 cites W1562074219 @default.
• W2012088617 cites W1564318084 @default.
• W2012088617 cites W1642027226 @default.
• W2012088617 cites W1854638296 @default.
• W2012088617 cites W1919902298 @default.
• W2012088617 cites W1931329582 @default.
• W2012088617 cites W1947939079 @default.
• W2012088617 cites W1952444941 @default.
• W2012088617 cites W1963632824 @default.
• W2012088617 cites W1966554631 @default.
• W2012088617 cites W1975682095 @default.
• W2012088617 cites W1976355501 @default.
• W2012088617 cites W1985294654 @default.
• W2012088617 cites W1987735044 @default.
• W2012088617 cites W1990555844 @default.
• W2012088617 cites W1999561404 @default.
• W2012088617 cites W2003182569 @default.
• W2012088617 cites W2009443186 @default.
• W2012088617 cites W2013015134 @default.
• W2012088617 cites W2016804485 @default.
• W2012088617 cites W2027581425 @default.
• W2012088617 cites W2040676910 @default.
• W2012088617 cites W2046205086 @default.
• W2012088617 cites W2052006922 @default.
• W2012088617 cites W2053236313 @default.
• W2012088617 cites W2057522151 @default.
• W2012088617 cites W2058425124 @default.
• W2012088617 cites W2059431619 @default.
• W2012088617 cites W2067640086 @default.
• W2012088617 cites W2070791475 @default.
• W2012088617 cites W2073242835 @default.
• W2012088617 cites W2081360252 @default.
• W2012088617 cites W2093276391 @default.
• W2012088617 cites W2098636562 @default.
• W2012088617 cites W2099918076 @default.
• W2012088617 cites W2100359781 @default.
• W2012088617 cites W2118736569 @default.
• W2012088617 cites W2123784213 @default.
• W2012088617 cites W2124890828 @default.
• W2012088617 cites W2126197815 @default.
• W2012088617 cites W2134742092 @default.
• W2012088617 cites W2147652122 @default.
• W2012088617 cites W2162432065 @default.
• W2012088617 cites W2167593148 @default.
• W2012088617 cites W2168079915 @default.
• W2012088617 cites W76119345 @default.
• W2012088617 doi "https://doi.org/10.1371/journal.ppat.1003293" @default.
• W2012088617 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3623720" @default.
• W2012088617 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23593003" @default.
• W2012088617 hasPublicationYear "2013" @default.
• W2012088617 type Work @default.
• W2012088617 sameAs 2012088617 @default.
• W2012088617 citedByCount "49" @default.
• W2012088617 countsByYear W20120886172013 @default.
• W2012088617 countsByYear W20120886172014 @default.
• W2012088617 countsByYear W20120886172015 @default.
• W2012088617 countsByYear W20120886172016 @default.
• W2012088617 countsByYear W20120886172017 @default.
• W2012088617 countsByYear W20120886172018 @default.
• W2012088617 countsByYear W20120886172019 @default.
• W2012088617 countsByYear W20120886172020 @default.
• W2012088617 countsByYear W20120886172021 @default.
• W2012088617 countsByYear W20120886172022 @default.
• W2012088617 countsByYear W20120886172023 @default.
• W2012088617 crossrefType "journal-article" @default.
• W2012088617 hasAuthorship W2012088617A5003951398 @default.
• W2012088617 hasAuthorship W2012088617A5008502588 @default.
• W2012088617 hasAuthorship W2012088617A5017348677 @default.
• W2012088617 hasAuthorship W2012088617A5038289225 @default.
• W2012088617 hasAuthorship W2012088617A5040066221 @default.
• W2012088617 hasAuthorship W2012088617A5052599084 @default.
• W2012088617 hasAuthorship W2012088617A5075407171 @default.
• W2012088617 hasAuthorship W2012088617A5079003683 @default.
• W2012088617 hasAuthorship W2012088617A5088453567 @default.
• W2012088617 hasAuthorship W2012088617A5091769869 @default.
• W2012088617 hasBestOaLocation W20120886171 @default.
• W2012088617 hasConcept C104317684 @default.
• W2012088617 hasConcept C148738053 @default.
• W2012088617 hasConcept C203014093 @default.
• W2012088617 hasConcept C2779727006 @default.
• W2012088617 hasConcept C51785407 @default.
• W2012088617 hasConcept C54355233 @default.

• next