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- W2012093148 abstract "In this report, we have compared the changes in the production of [Formula: see text] (initiator tRNA Met ) and tRNA Asn , which occur during erythroid differentiation in the Friend erythroleukemia cell. The relative steady-state concentration of these two tRNAs (relative to the total tRNA population) was measured by aminoacylation. The results show that while the relative steady-state concentration of [Formula: see text] changes very little in the cytoplasmic tRNA population, the relative concentration of tRNA Asn decreases during the first two days of differentiation and then undergoes an increase. This difference in the behavior of these two tRNAs is also seen when their relative concentrations in newly synthesized tRNA is examined. When tRNA is labeled with tritiated uridine for 24 h in vivo prior to isolation, the hybridization of this labeled tRNA to filter-bound tRNA genes shows that the relative concentration of [Formula: see text] in newly synthesized tRNA changes very little, while the relative concentration of newly synthesized tRNA Asn again decreases through the first 2 days of differentiation, and then undergoes a smaller increase. Thus, the production of these two tRNAs appears to be independently regulated. Independent regulation of synthesis is also observed when examining the production of these two tRNAs in isolated nuclei. During erythroid differentiation, the relative synthesis of [Formula: see text] (relative to total nuclear RNA synthesis) remains constant, while the relative synthesis of tRNA Asn undergoes periodic increases and decreases in value." @default.
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- W2012093148 date "1988-07-01" @default.
- W2012093148 modified "2023-10-14" @default.
- W2012093148 title "The independent regulation of and tRNAAsn synthesis during Friend cell erythroid differentiation" @default.
- W2012093148 doi "https://doi.org/10.1139/o88-088" @default.
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