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• W201209429 abstract "Research Article1 July 1994free access DP-1: a cell cycle-regulated and phosphorylated component of transcription factor DRTF1/E2F which is functionally important for recognition by pRb and the adenovirus E4 orf 6/7 protein. L.R. Bandara L.R. Bandara Laboratory of Eukaryotic Molecular Genetics, MRC National Institute for Medical Research, London, UK. Search for more papers by this author E.W. Lam E.W. Lam Laboratory of Eukaryotic Molecular Genetics, MRC National Institute for Medical Research, London, UK. Search for more papers by this author T.S. Sørensen T.S. Sørensen Laboratory of Eukaryotic Molecular Genetics, MRC National Institute for Medical Research, London, UK. Search for more papers by this author M. Zamanian M. Zamanian Laboratory of Eukaryotic Molecular Genetics, MRC National Institute for Medical Research, London, UK. Search for more papers by this author R. Girling R. Girling Laboratory of Eukaryotic Molecular Genetics, MRC National Institute for Medical Research, London, UK. Search for more papers by this author N.B. La Thangue N.B. La Thangue Laboratory of Eukaryotic Molecular Genetics, MRC National Institute for Medical Research, London, UK. Search for more papers by this author L.R. Bandara L.R. Bandara Laboratory of Eukaryotic Molecular Genetics, MRC National Institute for Medical Research, London, UK. Search for more papers by this author E.W. Lam E.W. Lam Laboratory of Eukaryotic Molecular Genetics, MRC National Institute for Medical Research, London, UK. Search for more papers by this author T.S. Sørensen T.S. Sørensen Laboratory of Eukaryotic Molecular Genetics, MRC National Institute for Medical Research, London, UK. Search for more papers by this author M. Zamanian M. Zamanian Laboratory of Eukaryotic Molecular Genetics, MRC National Institute for Medical Research, London, UK. Search for more papers by this author R. Girling R. Girling Laboratory of Eukaryotic Molecular Genetics, MRC National Institute for Medical Research, London, UK. Search for more papers by this author N.B. La Thangue N.B. La Thangue Laboratory of Eukaryotic Molecular Genetics, MRC National Institute for Medical Research, London, UK. Search for more papers by this author Author Information L.R. Bandara1, E.W. Lam1, T.S. Sørensen1, M. Zamanian1, R. Girling1 and N.B. La Thangue1 1Laboratory of Eukaryotic Molecular Genetics, MRC National Institute for Medical Research, London, UK. The EMBO Journal (1994)13:3104-3114https://doi.org/10.1002/j.1460-2075.1994.tb06609.x PDFDownload PDF of article text and main figures. ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinked InMendeleyWechatReddit Figures & Info The cellular transcription factor DRTF1/E2F integrates cell cycle events with the transcription apparatus through its cyclical interactions with important regulators of cellular proliferation. Two sequence-specific DNA binding proteins, DP-1 and E2F-1, are components of DRTF1/E2F which synergistically interact in a DP-1/E2F-1 heterodimer. Here, we show that DP-1 is a very frequent, possibly universal, component of DRTF1/E2F in 3T3 cells since it is present in all forms of the DNA binding activity that occur during cell cycle progression. Furthermore, the DP-1 polypeptide, which is phosphorylated, undergoes a phosphorylation-dependent mobility shift during the cell cycle suggesting that its level of phosphorylation is regulated during cell cycle progression. A C-terminal region in DP-1 can interact with pRb which, in the context of the DP-1/E2F-1 heterodimer, contributes to the efficiency of pRb binding. The DP-1/E2F-1 heterodimer specifically interacts with the adenovirus type 5 E4 orf 6/7 protein, to produce a DNA binding activity which binds co-operatively to, and transcriptionally activates through, two appropriately positioned E2F sites in a manner which resembles the regulation of DRTF1/E2F by E4 orf 6/7 during adenovirus infection. We conclude that DP-1 is a frequent and cell cycle-regulated component of DRTF1/E2F, and that in the DP-1/E2F-1 heterodimer it is functionally important for recognition by pRb and the E4 orf 6/7 protein. Previous ArticleNext Article Volume 13Issue 131 July 1994In this issue RelatedDetailsLoading ..." @default.
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• W201209429 title "DP-1: a cell cycle-regulated and phosphorylated component of transcription factor DRTF1/E2F which is functionally important for recognition by pRb and the adenovirus E4 orf 6/7 protein." @default.
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