FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2012094514> ?p ?o ?g. }

• W2012094514 endingPage "328" @default.
• W2012094514 startingPage "319" @default.
• W2012094514 abstract "It is believed that biosynthesis of lipid mediators in the central nervous system after cerebral ischemia-reperfusion starts with phospholipid hydrolysis by calcium-dependent phospholipases and is followed by oxygenation of released fatty acids (FAs). Here, we report an alternative pathway whereby cereberal ischemia-reperfusion triggered oxygenation of a mitochondria-specific phospholipid, cardiolipin (CL), is followed by its hydrolysis to yield monolyso-CLs and oxygenated derivatives of fatty (linoleic) acids. We used a model of global cerebral ischemia-reperfusion characterized by 9 minutes of asphyxia leading to asystole followed by cardiopulmonary resuscitation in postnatal day 17 rats. Global ischemia and cardiopulmonary resuscitation resulted in: (1) selective oxidation and hydrolysis of CLs, (2) accumulation of lyso-CLs and oxygenated free FAs, (3) activation of caspase 3/7 in the brain, and (4) motor and cognitive dysfunction. On the basis of these findings, we used a mitochondria targeted nitroxide electron scavenger, which prevented CL oxidation and subsequent hydrolysis, attenuated caspase activation, and improved neurocognitive outcome when administered after cardiac arrest. These data show that calcium-independent CL oxidation and subsequent hydrolysis represent a previously unidentified pathogenic mechanism of brain injury incurred by ischemia-reperfusion and a clinically relevant therapeutic target." @default.
• W2012094514 created "2016-06-24" @default.
• W2012094514 creator A5010982315 @default.
• W2012094514 creator A5018024103 @default.
• W2012094514 creator A5023531457 @default.
• W2012094514 creator A5025786667 @default.
• W2012094514 creator A5030333904 @default.
• W2012094514 creator A5030917251 @default.
• W2012094514 creator A5040760802 @default.
• W2012094514 creator A5055133721 @default.
• W2012094514 creator A5055486451 @default.
• W2012094514 creator A5058521832 @default.
• W2012094514 creator A5059406567 @default.
• W2012094514 creator A5060016417 @default.
• W2012094514 creator A5061593498 @default.
• W2012094514 creator A5074571144 @default.
• W2012094514 creator A5083782243 @default.
• W2012094514 creator A5090131713 @default.
• W2012094514 date "2014-11-19" @default.
• W2012094514 modified "2023-10-17" @default.
• W2012094514 title "Deciphering of Mitochondrial Cardiolipin Oxidative Signaling in Cerebral Ischemia-Reperfusion" @default.
• W2012094514 cites W1163466779 @default.
• W2012094514 cites W127276580 @default.
• W2012094514 cites W1963745194 @default.
• W2012094514 cites W1969770915 @default.
• W2012094514 cites W1982783526 @default.
• W2012094514 cites W2002033816 @default.
• W2012094514 cites W2007051705 @default.
• W2012094514 cites W2010130396 @default.
• W2012094514 cites W2012897199 @default.
• W2012094514 cites W2023849102 @default.
• W2012094514 cites W2025211038 @default.
• W2012094514 cites W2035351765 @default.
• W2012094514 cites W2037580085 @default.
• W2012094514 cites W2038559524 @default.
• W2012094514 cites W2048705687 @default.
• W2012094514 cites W2053557775 @default.
• W2012094514 cites W2053869318 @default.
• W2012094514 cites W2060981140 @default.
• W2012094514 cites W2062897750 @default.
• W2012094514 cites W2068049473 @default.
• W2012094514 cites W2070369172 @default.
• W2012094514 cites W2070620348 @default.
• W2012094514 cites W2077755739 @default.
• W2012094514 cites W2085636087 @default.
• W2012094514 cites W2091601828 @default.
• W2012094514 cites W2095057456 @default.
• W2012094514 cites W2100726346 @default.
• W2012094514 cites W2110526875 @default.
• W2012094514 cites W2119159602 @default.
• W2012094514 cites W2133498992 @default.
• W2012094514 cites W2136222911 @default.
• W2012094514 cites W2142047675 @default.
• W2012094514 cites W2154378961 @default.
• W2012094514 doi "https://doi.org/10.1038/jcbfm.2014.204" @default.
• W2012094514 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4426750" @default.
• W2012094514 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25407268" @default.
• W2012094514 hasPublicationYear "2014" @default.
• W2012094514 type Work @default.
• W2012094514 sameAs 2012094514 @default.
• W2012094514 citedByCount "48" @default.
• W2012094514 countsByYear W20120945142015 @default.
• W2012094514 countsByYear W20120945142016 @default.
• W2012094514 countsByYear W20120945142017 @default.
• W2012094514 countsByYear W20120945142018 @default.
• W2012094514 countsByYear W20120945142019 @default.
• W2012094514 countsByYear W20120945142020 @default.
• W2012094514 countsByYear W20120945142021 @default.
• W2012094514 countsByYear W20120945142022 @default.
• W2012094514 countsByYear W20120945142023 @default.
• W2012094514 crossrefType "journal-article" @default.
• W2012094514 hasAuthorship W2012094514A5010982315 @default.
• W2012094514 hasAuthorship W2012094514A5018024103 @default.
• W2012094514 hasAuthorship W2012094514A5023531457 @default.
• W2012094514 hasAuthorship W2012094514A5025786667 @default.
• W2012094514 hasAuthorship W2012094514A5030333904 @default.
• W2012094514 hasAuthorship W2012094514A5030917251 @default.
• W2012094514 hasAuthorship W2012094514A5040760802 @default.
• W2012094514 hasAuthorship W2012094514A5055133721 @default.
• W2012094514 hasAuthorship W2012094514A5055486451 @default.
• W2012094514 hasAuthorship W2012094514A5058521832 @default.
• W2012094514 hasAuthorship W2012094514A5059406567 @default.
• W2012094514 hasAuthorship W2012094514A5060016417 @default.
• W2012094514 hasAuthorship W2012094514A5061593498 @default.
• W2012094514 hasAuthorship W2012094514A5074571144 @default.
• W2012094514 hasAuthorship W2012094514A5083782243 @default.
• W2012094514 hasAuthorship W2012094514A5090131713 @default.
• W2012094514 hasBestOaLocation W20120945141 @default.
• W2012094514 hasConcept C126322002 @default.
• W2012094514 hasConcept C185592680 @default.
• W2012094514 hasConcept C25498285 @default.
• W2012094514 hasConcept C2778918659 @default.
• W2012094514 hasConcept C2780114680 @default.
• W2012094514 hasConcept C2781302388 @default.
• W2012094514 hasConcept C28859421 @default.
• W2012094514 hasConcept C41625074 @default.
• W2012094514 hasConcept C541997718 @default.
• W2012094514 hasConcept C55493867 @default.

• next