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• W2012095162 abstract "The purpose of this study was to determine the prevalence of stria vascularis atrophy in individuals with presbycusis and flat audiometric patterns of hearing loss. Individuals with presbycusis have historically been categorized by the shape of their audiograms, and flat audiometric thresholds have been reported to be associated with atrophy of the stria vascularis. Stria vascularis volume was not measured in these studies.Retrospective case review.Archival human temporal bones from individuals with presbycusis were selected on the basis of strict audiometric criteria for flat audiometric thresholds. Six temporal bones that met these criteria were identified and compared with 10 temporal bones in individuals with normal hearing. A unique quantitative method was developed to measure the stria vascularis volume in these temporal bones. The hair cell and spiral ganglion cell populations also were quantitatively evaluated.Only one of the six individuals with presbycusis and flat audiometric thresholds had significant atrophy of the stria vascularis. This individual with stria vascularis atrophy also had reduced inner hair cell, outer hair cell, and ganglion cell populations. Three of the individuals with presbycusis had spiral ganglion cell loss, three individuals had inner hair cell loss, and all six individuals had outer hair cell loss.The results of this investigation suggest that individuals with presbycusis and flat audiometric patterns of hearing loss infrequently have stria vascularis atrophy. Outer hair cell loss alone or in combination with inner hair cell or ganglion cell loss may be the cause of flat audiometric thresholds in individuals with presbycusis." @default.
• W2012095162 created "2016-06-24" @default.
• W2012095162 creator A5036002705 @default.
• W2012095162 creator A5058060074 @default.
• W2012095162 date "2010-09-03" @default.
• W2012095162 modified "2023-10-17" @default.
• W2012095162 title "Presbycusis: A human temporal bone study of individuals with flat audiometric patterns of hearing loss using a new method to quantify stria vascularis volume" @default.
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• W2012095162 doi "https://doi.org/10.1097/00005537-200310000-00006" @default.
• W2012095162 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/14520091" @default.
• W2012095162 hasPublicationYear "2010" @default.
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