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• W2012095191 abstract "Deficits in dopamine D2/D3 receptor (D2R/D3R) binding availability using PET imaging have been reported in obese humans and rodents. Similar deficits have been reported in cocaine-addicts and cocaine-exposed primates. We found that D2R/D3R binding availability negatively correlated with measures of body weight at the time of scan (ventral striatum), at 1 (ventral striatum) and 2 months (dorsal and ventral striatum) post scan in rats. Cocaine preference was negatively correlated with D2R/D3R binding availability 2 months (ventral striatum) post scan. Our findings suggest that inherent deficits in striatal D2R/D3R signaling are related to obesity and drug addiction susceptibility and that ventral and dorsal striatum serve dissociable roles in maintaining weight gain and cocaine preference. Measuring D2R/D3R binding availability provides a way for assessing susceptibility to weight gain and cocaine abuse in rodents and given the translational nature of PET imaging, potentially primates and humans." @default.
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• W2012095191 date "2012-01-01" @default.
• W2012095191 modified "2023-10-13" @default.
• W2012095191 title "PET imaging predicts future body weight and cocaine preference" @default.
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• W2012095191 doi "https://doi.org/10.1016/j.neuroimage.2011.08.028" @default.
• W2012095191 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3230743" @default.
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