FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2012095404> ?p ?o ?g. }

• W2012095404 endingPage "4263" @default.
• W2012095404 startingPage "4250" @default.
• W2012095404 abstract "We show that human stefin B, a protease inhibitor from the family of cystatins, is a copper binding protein, unlike stefin A. We have used isothermal titration calorimetry to directly monitor the binding event at pH 7 and pH 5. At pH 7 stefin B shows a picomolar affinity for copper but at pH 5 the affinity is in the nanomolar range. There is no difference in the affinity of copper between the wildtype stefin B (E31 isoform) and a variant (Y31 isoform), whereas the mutant (P79S), which is tetrameric, does not bind copper. The conformation of stefin B remains unaltered by copper binding. It is known that below pH 5 stefin B undergoes a conformational change and amyloid fibril formation. We show that copper binding inhibits the amyloid fibril formation and, to a lesser degree, the initial aggregation. Similarities to and differences from other copper binding amyloidogenic proteins are discussed." @default.
• W2012095404 created "2016-06-24" @default.
• W2012095404 creator A5035554801 @default.
• W2012095404 creator A5044523008 @default.
• W2012095404 creator A5052193029 @default.
• W2012095404 creator A5072478541 @default.
• W2012095404 creator A5077949525 @default.
• W2012095404 creator A5091019722 @default.
• W2012095404 date "2006-08-29" @default.
• W2012095404 modified "2023-10-04" @default.
• W2012095404 title "High affinity copper binding by stefin B (cystatin B) and its role in the inhibition of amyloid fibrillation" @default.
• W2012095404 cites W1501239505 @default.
• W2012095404 cites W1591864042 @default.
• W2012095404 cites W1704732331 @default.
• W2012095404 cites W1860073488 @default.
• W2012095404 cites W1878275597 @default.
• W2012095404 cites W1966618264 @default.
• W2012095404 cites W1968675059 @default.
• W2012095404 cites W1969387743 @default.
• W2012095404 cites W1970232844 @default.
• W2012095404 cites W1971549848 @default.
• W2012095404 cites W1972068748 @default.
• W2012095404 cites W1978363949 @default.
• W2012095404 cites W1979479317 @default.
• W2012095404 cites W1984687991 @default.
• W2012095404 cites W1987467162 @default.
• W2012095404 cites W1991241547 @default.
• W2012095404 cites W2006799495 @default.
• W2012095404 cites W2018333394 @default.
• W2012095404 cites W2021722828 @default.
• W2012095404 cites W2024443281 @default.
• W2012095404 cites W2024888626 @default.
• W2012095404 cites W2027659335 @default.
• W2012095404 cites W2028345570 @default.
• W2012095404 cites W2037030307 @default.
• W2012095404 cites W2048469936 @default.
• W2012095404 cites W2055378374 @default.
• W2012095404 cites W2070635941 @default.
• W2012095404 cites W2073375862 @default.
• W2012095404 cites W2073516240 @default.
• W2012095404 cites W2076834744 @default.
• W2012095404 cites W2076972075 @default.
• W2012095404 cites W2077595384 @default.
• W2012095404 cites W2085663169 @default.
• W2012095404 cites W2086599111 @default.
• W2012095404 cites W2089355216 @default.
• W2012095404 cites W2093861673 @default.
• W2012095404 cites W2097632069 @default.
• W2012095404 cites W2107677733 @default.
• W2012095404 cites W2108490599 @default.
• W2012095404 cites W2114059449 @default.
• W2012095404 cites W2131718952 @default.
• W2012095404 cites W2132670203 @default.
• W2012095404 cites W2133538960 @default.
• W2012095404 cites W2140260269 @default.
• W2012095404 cites W2140580771 @default.
• W2012095404 cites W2144695655 @default.
• W2012095404 cites W2148225540 @default.
• W2012095404 cites W2148671954 @default.
• W2012095404 cites W2149826984 @default.
• W2012095404 cites W2153026244 @default.
• W2012095404 cites W2161275159 @default.
• W2012095404 cites W4238052567 @default.
• W2012095404 cites W4253709458 @default.
• W2012095404 doi "https://doi.org/10.1111/j.1742-4658.2006.05426.x" @default.
• W2012095404 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16939620" @default.
• W2012095404 hasPublicationYear "2006" @default.
• W2012095404 type Work @default.
• W2012095404 sameAs 2012095404 @default.
• W2012095404 citedByCount "27" @default.
• W2012095404 countsByYear W20120954042012 @default.
• W2012095404 countsByYear W20120954042013 @default.
• W2012095404 countsByYear W20120954042014 @default.
• W2012095404 countsByYear W20120954042015 @default.
• W2012095404 countsByYear W20120954042016 @default.
• W2012095404 countsByYear W20120954042017 @default.
• W2012095404 countsByYear W20120954042019 @default.
• W2012095404 countsByYear W20120954042020 @default.
• W2012095404 countsByYear W20120954042021 @default.
• W2012095404 countsByYear W20120954042022 @default.
• W2012095404 crossrefType "journal-article" @default.
• W2012095404 hasAuthorship W2012095404A5035554801 @default.
• W2012095404 hasAuthorship W2012095404A5044523008 @default.
• W2012095404 hasAuthorship W2012095404A5052193029 @default.
• W2012095404 hasAuthorship W2012095404A5072478541 @default.
• W2012095404 hasAuthorship W2012095404A5077949525 @default.
• W2012095404 hasAuthorship W2012095404A5091019722 @default.
• W2012095404 hasConcept C104317684 @default.
• W2012095404 hasConcept C12554922 @default.
• W2012095404 hasConcept C156911925 @default.
• W2012095404 hasConcept C159641895 @default.
• W2012095404 hasConcept C178790620 @default.
• W2012095404 hasConcept C179104552 @default.
• W2012095404 hasConcept C181199279 @default.
• W2012095404 hasConcept C185592680 @default.
• W2012095404 hasConcept C2776714187 @default.
• W2012095404 hasConcept C2777633098 @default.
• W2012095404 hasConcept C2779548226 @default.

• next