FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2012098081> ?p ?o ?g. }

• W2012098081 endingPage "91" @default.
• W2012098081 startingPage "84" @default.
• W2012098081 abstract "This study was undertaken to gain insights into the mechanism for Δ9-tetrahydrocannabinol (Δ9-THC)-mediated suppression of primary immunoglobulin M (IgM) responses in humans. An in vitro activation model, which employs cell surface-expressed CD40 ligand (CD40L) and recombinant cytokines (interleukin (IL)-2, -6, and -10), was used to differentiate human peripheral blood (HPB) naïve B cells into IgM secreting cells. Pretreatment with Δ9-THC significantly decreased the number of IgM secreting cells as determined by ELISPOT. The attenuation of IgM secretion by Δ9-THC involved, at least in part, the impairment of plasma cell differentiation as evidenced by suppression of immunoglobulin joining chain (IgJ) mRNA expression. The analysis at each of two different stages critically involved in plasma cell differentiation indicates that Δ9-THC impaired both the primary activation stage and proliferation of B cells. Interestingly, Δ9-THC selectively suppressed the surface expression of CD80, but not other measured B-cell activation markers (CD69, CD86, and ICAM1). Furthermore, pretreatment with Δ9-THC was accompanied by a robust decrease of STAT3 phosphorylation, whereas the phosphorylation of the p65 NFκB subunit was not affected. Collectively, these data provide new insights into the mechanisms for impaired B cell function by Δ9-THC." @default.
• W2012098081 created "2016-06-24" @default.
• W2012098081 creator A5003836269 @default.
• W2012098081 creator A5020056751 @default.
• W2012098081 creator A5020366031 @default.
• W2012098081 creator A5022564932 @default.
• W2012098081 creator A5049068674 @default.
• W2012098081 date "2013-08-01" @default.
• W2012098081 modified "2023-09-26" @default.
• W2012098081 title "Suppression by Δ9-tetrahydrocannabinol of the primary immunoglobulin M response by human peripheral blood B cells is associated with impaired STAT3 activation" @default.
• W2012098081 cites W1495466419 @default.
• W2012098081 cites W1608925095 @default.
• W2012098081 cites W1971670799 @default.
• W2012098081 cites W1978556684 @default.
• W2012098081 cites W1981118166 @default.
• W2012098081 cites W1981964639 @default.
• W2012098081 cites W1984035854 @default.
• W2012098081 cites W1997247528 @default.
• W2012098081 cites W1999680253 @default.
• W2012098081 cites W2000887760 @default.
• W2012098081 cites W2009859686 @default.
• W2012098081 cites W2026092903 @default.
• W2012098081 cites W2026831884 @default.
• W2012098081 cites W2040633452 @default.
• W2012098081 cites W2062266720 @default.
• W2012098081 cites W2070217465 @default.
• W2012098081 cites W2071217758 @default.
• W2012098081 cites W2072422429 @default.
• W2012098081 cites W2082450387 @default.
• W2012098081 cites W2083416451 @default.
• W2012098081 cites W2083797611 @default.
• W2012098081 cites W2086777766 @default.
• W2012098081 cites W2097930072 @default.
• W2012098081 cites W2107277218 @default.
• W2012098081 cites W2111585268 @default.
• W2012098081 cites W2114660866 @default.
• W2012098081 cites W2115406982 @default.
• W2012098081 cites W2118944694 @default.
• W2012098081 cites W2123369755 @default.
• W2012098081 cites W2128751441 @default.
• W2012098081 cites W2132599616 @default.
• W2012098081 cites W2137540753 @default.
• W2012098081 cites W2149748445 @default.
• W2012098081 cites W2154351751 @default.
• W2012098081 cites W2154901456 @default.
• W2012098081 cites W2163229826 @default.
• W2012098081 cites W2163643314 @default.
• W2012098081 cites W2164121384 @default.
• W2012098081 cites W2165197737 @default.
• W2012098081 cites W2168065686 @default.
• W2012098081 doi "https://doi.org/10.1016/j.tox.2013.05.009" @default.
• W2012098081 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3746317" @default.
• W2012098081 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23727458" @default.
• W2012098081 hasPublicationYear "2013" @default.
• W2012098081 type Work @default.
• W2012098081 sameAs 2012098081 @default.
• W2012098081 citedByCount "7" @default.
• W2012098081 countsByYear W20120980812016 @default.
• W2012098081 countsByYear W20120980812017 @default.
• W2012098081 countsByYear W20120980812018 @default.
• W2012098081 countsByYear W20120980812019 @default.
• W2012098081 countsByYear W20120980812022 @default.
• W2012098081 countsByYear W20120980812023 @default.
• W2012098081 crossrefType "journal-article" @default.
• W2012098081 hasAuthorship W2012098081A5003836269 @default.
• W2012098081 hasAuthorship W2012098081A5020056751 @default.
• W2012098081 hasAuthorship W2012098081A5020366031 @default.
• W2012098081 hasAuthorship W2012098081A5022564932 @default.
• W2012098081 hasAuthorship W2012098081A5049068674 @default.
• W2012098081 hasBestOaLocation W20120980812 @default.
• W2012098081 hasConcept C134018914 @default.
• W2012098081 hasConcept C153911025 @default.
• W2012098081 hasConcept C154317977 @default.
• W2012098081 hasConcept C159654299 @default.
• W2012098081 hasConcept C185592680 @default.
• W2012098081 hasConcept C200180986 @default.
• W2012098081 hasConcept C202751555 @default.
• W2012098081 hasConcept C203014093 @default.
• W2012098081 hasConcept C2776090121 @default.
• W2012098081 hasConcept C2778297628 @default.
• W2012098081 hasConcept C2778453870 @default.
• W2012098081 hasConcept C2781101188 @default.
• W2012098081 hasConcept C39347974 @default.
• W2012098081 hasConcept C55493867 @default.
• W2012098081 hasConcept C67662055 @default.
• W2012098081 hasConcept C86803240 @default.
• W2012098081 hasConcept C8891405 @default.
• W2012098081 hasConceptScore W2012098081C134018914 @default.
• W2012098081 hasConceptScore W2012098081C153911025 @default.
• W2012098081 hasConceptScore W2012098081C154317977 @default.
• W2012098081 hasConceptScore W2012098081C159654299 @default.
• W2012098081 hasConceptScore W2012098081C185592680 @default.
• W2012098081 hasConceptScore W2012098081C200180986 @default.
• W2012098081 hasConceptScore W2012098081C202751555 @default.
• W2012098081 hasConceptScore W2012098081C203014093 @default.
• W2012098081 hasConceptScore W2012098081C2776090121 @default.
• W2012098081 hasConceptScore W2012098081C2778297628 @default.
• W2012098081 hasConceptScore W2012098081C2778453870 @default.

• next