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• W2012099265 endingPage "598" @default.
• W2012099265 startingPage "583" @default.
• W2012099265 abstract "The effects of simultaneous administrations of Cyclosporin A (CsA) and Glyburide on the immune system of rats has been evaluated in terms of Interleukin-2 (IL-2) production by Concanavalin A (ConA) stimulated splenocytes and exogenous IL-2 binding capacity. The inhibitory effect of Cyclosporin A on IL-2 production of lymphoid cells is well known. Spleen cells from rats receiving CsA had reduced levels of IL-2 when compared to untreated controls or rats receiving Glyburide only. Splenocytes from rats receiving both drugs had reduced levels of IL-2 when they were sacrificed 24 hours after one or three CsA administrations; instead when the animals were sacrificed 6 days after three CsA administrations, their ability of producing IL-2 is increased as well as increasing exogenous IL-2 binding capacity. These findings let us hypothesize that when there are lower concentrations of CsA in lymphocytes there is an increase of cellular metabolism induced by Glyburide that leads to an increase in IL-2 secretion and in IL-2 receptor expression on cellular surface restoring these levels to normal or slightly above normal levels." @default.
• W2012099265 created "2016-06-24" @default.
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• W2012099265 date "1999-01-01" @default.
• W2012099265 modified "2023-09-26" @default.
• W2012099265 title "Effects of Glyburide-Cyclosporin A Interaction on Interleukin-2 Production in Rats¹" @default.
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• W2012099265 doi "https://doi.org/10.3109/08923979909007127" @default.
• W2012099265 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10466081" @default.
• W2012099265 hasPublicationYear "1999" @default.
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