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• W2012099558 abstract "Male and female weanling rats, divided into three groups, were maintained for 30, 60 and 90 days on an experimental diet without vitamin C. The drinking water containing or devoid of vitamin C was offered each day. The first group had no vitamin C; the second group or control had normal vitamin C and the third group had above-normal vitamin C in the water. Twenty-four hours after the last feeding, the animals were decapitated and the liver microsomes plus soluble fraction (9000 g) were prepared. This preparation was used for O-demethylase and the hydroxylase assays of aflatoxins B1 and G1 (AFB1 and AFG1). Results from O-demethylation in both control and experimental groups of both sexes, showed that O-demethylase activity is directly related to ascorbic acid content of the water. But the hydroxylase activity in male and female animals maintained on the same diet showed only slight differences. In the male, there was an increase with time of hydroxylase activity with AFB1 up to 60 days and a decrease at 90 days. Hydroxylation assay revealed that in the female, metabolism of AFB1 increased at 30 days but decreased at 60 and 90 days." @default.
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• W2012099558 date "1978-03-01" @default.
• W2012099558 modified "2023-09-23" @default.
• W2012099558 title "Effect of vitamin a deficiency and excess on aflatoxin metabolism in the rabbit" @default.
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• W2012099558 doi "https://doi.org/10.1016/0006-2952(78)90540-3" @default.
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