Matches in SemOpenAlex for { <https://semopenalex.org/work/W2012099880> ?p ?o ?g. }
- W2012099880 endingPage "2264" @default.
- W2012099880 startingPage "2256" @default.
- W2012099880 abstract "Chronic hepatitis C virus (HCV) infection of the liver with either genotype 1 or genotype 3 gives rise to distinct pathologies, and the two viral genotypes respond differently to antiviral therapy.To understand these clinical differences, we compared gene transcription profiles in liver biopsies from patients infected with either gt1 or gt3, and uninfected controls.Gt1-infected biopsies displayed elevated levels of transcripts regulated by type I and type III interferons (IFN), including genes that predict response to IFN-α therapy. In contrast, genes controlled by IFN-γ were induced in gt3-infected biopsies. Moreover, IFN-γ levels were higher in gt3-infected biopsies. Analysis of hepatocyte-derived cell lines confirmed that the genes upregulated in gt3 infection were preferentially induced by IFN-γ. The transcriptional profile of gt3 infection was unaffected by IFNL4 polymorphisms, providing a rationale for the reduced predictive power of IFNL genotyping in gt3-infected patients.The interactions between HCV genotypes 1 and 3 and hepatocytes are distinct. These unique interactions provide avenues to explore the biological mechanisms that drive viral genotype-specific differences in disease progression and treatment response. A greater understanding of the distinct host-pathogen interactions of the different HCV genotypes is required to facilitate optimal management of HCV infection." @default.
- W2012099880 created "2016-06-24" @default.
- W2012099880 creator A5006670345 @default.
- W2012099880 creator A5007804720 @default.
- W2012099880 creator A5022405565 @default.
- W2012099880 creator A5031085183 @default.
- W2012099880 creator A5051926617 @default.
- W2012099880 creator A5053053781 @default.
- W2012099880 creator A5060555512 @default.
- W2012099880 creator A5062152339 @default.
- W2012099880 creator A5065502978 @default.
- W2012099880 creator A5087719558 @default.
- W2012099880 creator A5089334488 @default.
- W2012099880 date "2015-04-07" @default.
- W2012099880 modified "2023-09-27" @default.
- W2012099880 title "Viral genotype correlates with distinct liver gene transcription signatures in chronic hepatitis C virus infection" @default.
- W2012099880 cites W1604557454 @default.
- W2012099880 cites W1969720994 @default.
- W2012099880 cites W1975519799 @default.
- W2012099880 cites W1994879221 @default.
- W2012099880 cites W2001781369 @default.
- W2012099880 cites W2003772658 @default.
- W2012099880 cites W2017013905 @default.
- W2012099880 cites W2020173029 @default.
- W2012099880 cites W2025843699 @default.
- W2012099880 cites W2026067734 @default.
- W2012099880 cites W2026430330 @default.
- W2012099880 cites W2026614040 @default.
- W2012099880 cites W2028439225 @default.
- W2012099880 cites W2034641125 @default.
- W2012099880 cites W2034966611 @default.
- W2012099880 cites W2038576929 @default.
- W2012099880 cites W2053960602 @default.
- W2012099880 cites W2055949285 @default.
- W2012099880 cites W2057211436 @default.
- W2012099880 cites W2058538904 @default.
- W2012099880 cites W2063285149 @default.
- W2012099880 cites W2077467499 @default.
- W2012099880 cites W2078251659 @default.
- W2012099880 cites W2078586740 @default.
- W2012099880 cites W2085202049 @default.
- W2012099880 cites W2086409213 @default.
- W2012099880 cites W2096347191 @default.
- W2012099880 cites W2100305481 @default.
- W2012099880 cites W2105764241 @default.
- W2012099880 cites W2111357931 @default.
- W2012099880 cites W2115123532 @default.
- W2012099880 cites W2124641180 @default.
- W2012099880 cites W2127997174 @default.
- W2012099880 cites W2133036275 @default.
- W2012099880 cites W2139252405 @default.
- W2012099880 cites W2159163240 @default.
- W2012099880 cites W2163559237 @default.
- W2012099880 cites W2170103725 @default.
- W2012099880 doi "https://doi.org/10.1111/liv.12830" @default.
- W2012099880 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4949513" @default.
- W2012099880 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25800823" @default.
- W2012099880 hasPublicationYear "2015" @default.
- W2012099880 type Work @default.
- W2012099880 sameAs 2012099880 @default.
- W2012099880 citedByCount "10" @default.
- W2012099880 countsByYear W20120998802015 @default.
- W2012099880 countsByYear W20120998802016 @default.
- W2012099880 countsByYear W20120998802018 @default.
- W2012099880 countsByYear W20120998802019 @default.
- W2012099880 countsByYear W20120998802022 @default.
- W2012099880 crossrefType "journal-article" @default.
- W2012099880 hasAuthorship W2012099880A5006670345 @default.
- W2012099880 hasAuthorship W2012099880A5007804720 @default.
- W2012099880 hasAuthorship W2012099880A5022405565 @default.
- W2012099880 hasAuthorship W2012099880A5031085183 @default.
- W2012099880 hasAuthorship W2012099880A5051926617 @default.
- W2012099880 hasAuthorship W2012099880A5053053781 @default.
- W2012099880 hasAuthorship W2012099880A5060555512 @default.
- W2012099880 hasAuthorship W2012099880A5062152339 @default.
- W2012099880 hasAuthorship W2012099880A5065502978 @default.
- W2012099880 hasAuthorship W2012099880A5087719558 @default.
- W2012099880 hasAuthorship W2012099880A5089334488 @default.
- W2012099880 hasBestOaLocation W20120998801 @default.
- W2012099880 hasConcept C104317684 @default.
- W2012099880 hasConcept C135763542 @default.
- W2012099880 hasConcept C142462285 @default.
- W2012099880 hasConcept C159047783 @default.
- W2012099880 hasConcept C203014093 @default.
- W2012099880 hasConcept C2522874641 @default.
- W2012099880 hasConcept C2776178377 @default.
- W2012099880 hasConcept C2776408679 @default.
- W2012099880 hasConcept C2777075537 @default.
- W2012099880 hasConcept C3019392825 @default.
- W2012099880 hasConcept C31467283 @default.
- W2012099880 hasConcept C54355233 @default.
- W2012099880 hasConcept C55493867 @default.
- W2012099880 hasConcept C86803240 @default.
- W2012099880 hasConcept C8891405 @default.
- W2012099880 hasConceptScore W2012099880C104317684 @default.
- W2012099880 hasConceptScore W2012099880C135763542 @default.
- W2012099880 hasConceptScore W2012099880C142462285 @default.
- W2012099880 hasConceptScore W2012099880C159047783 @default.