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- W2012099961 endingPage "136" @default.
- W2012099961 startingPage "128" @default.
- W2012099961 abstract "Genome instability contributes to cancer development and accelerates age-related pathologies as evidenced by a variety of congenital cancer susceptibility and progeroid syndromes that are caused by defects in genome maintenance mechanisms. DNA damage response (DDR) pathways that are mediated through the tumor suppressor p53 play an important role in the cell-intrinsic responses to genome instability, including a transient cell cycle arrest, senescence and apoptosis. Both senescence and apoptosis are powerful tumor-suppressive pathways preventing the uncontrolled proliferation of transformed cells. However, both pathways can potentially deplete stem and progenitor cell pools, thus promoting tissue degeneration and organ failure, which are both hallmarks of aging. p53 signaling is also involved in mediating non-cell-autonomous interactions with the innate immune system and in the systemic adjustments during the aging process. The network of p53 target genes thus functions as an important regulator of cancer prevention and aging." @default.
- W2012099961 created "2016-06-24" @default.
- W2012099961 creator A5030035319 @default.
- W2012099961 creator A5062040602 @default.
- W2012099961 date "2012-03-01" @default.
- W2012099961 modified "2023-09-28" @default.
- W2012099961 title "The p53 network: cellular and systemic DNA damage responses in aging and cancer" @default.
- W2012099961 cites W1650797637 @default.
- W2012099961 cites W1968958521 @default.
- W2012099961 cites W1970249544 @default.
- W2012099961 cites W1970332601 @default.
- W2012099961 cites W1972618720 @default.
- W2012099961 cites W1979041271 @default.
- W2012099961 cites W1981148605 @default.
- W2012099961 cites W1984185924 @default.
- W2012099961 cites W1985028322 @default.
- W2012099961 cites W1986076152 @default.
- W2012099961 cites W1988008469 @default.
- W2012099961 cites W1995648202 @default.
- W2012099961 cites W1997439652 @default.
- W2012099961 cites W1998492363 @default.
- W2012099961 cites W2000823493 @default.
- W2012099961 cites W2001733842 @default.
- W2012099961 cites W2004273407 @default.
- W2012099961 cites W2004314923 @default.
- W2012099961 cites W2005542290 @default.
- W2012099961 cites W2010086173 @default.
- W2012099961 cites W2010114834 @default.
- W2012099961 cites W2010417927 @default.
- W2012099961 cites W2016375116 @default.
- W2012099961 cites W2022075548 @default.
- W2012099961 cites W2022487205 @default.
- W2012099961 cites W2022572059 @default.
- W2012099961 cites W2023696449 @default.
- W2012099961 cites W2025476423 @default.
- W2012099961 cites W2028361915 @default.
- W2012099961 cites W2031484851 @default.
- W2012099961 cites W2034805414 @default.
- W2012099961 cites W2034916584 @default.
- W2012099961 cites W2039196160 @default.
- W2012099961 cites W2041156660 @default.
- W2012099961 cites W2041552603 @default.
- W2012099961 cites W2042461504 @default.
- W2012099961 cites W2042499074 @default.
- W2012099961 cites W2042716686 @default.
- W2012099961 cites W2047160541 @default.
- W2012099961 cites W2048376025 @default.
- W2012099961 cites W2048614750 @default.
- W2012099961 cites W2055349083 @default.
- W2012099961 cites W2057289143 @default.
- W2012099961 cites W2058647415 @default.
- W2012099961 cites W2058794142 @default.
- W2012099961 cites W2059051391 @default.
- W2012099961 cites W2059971436 @default.
- W2012099961 cites W2067751798 @default.
- W2012099961 cites W2069519394 @default.
- W2012099961 cites W2072609916 @default.
- W2012099961 cites W2074832995 @default.
- W2012099961 cites W2077180087 @default.
- W2012099961 cites W2077436902 @default.
- W2012099961 cites W2077450385 @default.
- W2012099961 cites W2080245613 @default.
- W2012099961 cites W2080717926 @default.
- W2012099961 cites W2080726412 @default.
- W2012099961 cites W2081894694 @default.
- W2012099961 cites W2082559623 @default.
- W2012099961 cites W2083714302 @default.
- W2012099961 cites W2084695608 @default.
- W2012099961 cites W2086877549 @default.
- W2012099961 cites W2087635687 @default.
- W2012099961 cites W2088740611 @default.
- W2012099961 cites W2091369486 @default.
- W2012099961 cites W2093355627 @default.
- W2012099961 cites W2096452837 @default.
- W2012099961 cites W2096587251 @default.
- W2012099961 cites W2097059325 @default.
- W2012099961 cites W2097651998 @default.
- W2012099961 cites W2099135369 @default.
- W2012099961 cites W2099952417 @default.
- W2012099961 cites W2101428185 @default.
- W2012099961 cites W2104908670 @default.
- W2012099961 cites W2106117065 @default.
- W2012099961 cites W2111772438 @default.
- W2012099961 cites W2112968535 @default.
- W2012099961 cites W2116054786 @default.
- W2012099961 cites W2118682325 @default.
- W2012099961 cites W2118750047 @default.
- W2012099961 cites W2120936083 @default.
- W2012099961 cites W2121371748 @default.
- W2012099961 cites W2128564242 @default.
- W2012099961 cites W2132915404 @default.
- W2012099961 cites W2135829603 @default.
- W2012099961 cites W2136545880 @default.
- W2012099961 cites W2137304974 @default.
- W2012099961 cites W2137694720 @default.
- W2012099961 cites W2142205521 @default.
- W2012099961 cites W2145200068 @default.
- W2012099961 cites W2148479228 @default.