Matches in SemOpenAlex for { <https://semopenalex.org/work/W2012101044> ?p ?o ?g. }
- W2012101044 endingPage "660" @default.
- W2012101044 startingPage "646" @default.
- W2012101044 abstract "Severe hypoglycemia constitutes a medical emergency, involving seizures, coma and death. We hypothesized that seizures, during limited substrate availability, aggravate hypoglycemia-induced brain damage. Using immature isolated, intact hippocampi and frontal neocortical blocks subjected to low glucose perfusion, we characterized hypoglycemic (neuroglycopenic) seizures in vitro during transient hypoglycemia and their effects on synaptic transmission and glycogen content. Hippocampal hypoglycemic seizures were always followed by an irreversible reduction (>60% loss) in synaptic transmission and were occasionally accompanied by spreading depression-like events. Hypoglycemic seizures occurred more frequently with decreasing hypoglycemic extracellular glucose concentrations. In contrast, no hypoglycemic seizures were generated in the neocortex during transient hypoglycemia, and the reduction of synaptic transmission was reversible (<60% loss). Hypoglycemic seizures in the hippocampus were abolished by NMDA and non-NMDA antagonists. The anticonvulsant, midazolam, but neither phenytoin nor valproate, also abolished hypoglycemic seizures. Non-glycolytic, oxidative substrates attenuated, but did not abolish, hypoglycemic seizure activity and were unable to support synaptic transmission, even in the presence of the adenosine (A1) antagonist, DPCPX. Complete prevention of hypoglycemic seizures always led to the maintenance of synaptic transmission. A quantitative glycogen assay demonstrated that hypoglycemic seizures, in vitro, during hypoglycemia deplete hippocampal glycogen. These data suggest that suppressing seizures during hypoglycemia may decrease subsequent neuronal damage and dysfunction." @default.
- W2012101044 created "2016-06-24" @default.
- W2012101044 creator A5028699556 @default.
- W2012101044 creator A5030051787 @default.
- W2012101044 creator A5044113968 @default.
- W2012101044 creator A5055158979 @default.
- W2012101044 creator A5056031675 @default.
- W2012101044 creator A5062676942 @default.
- W2012101044 creator A5077435882 @default.
- W2012101044 creator A5080089008 @default.
- W2012101044 creator A5091196994 @default.
- W2012101044 date "2007-06-01" @default.
- W2012101044 modified "2023-10-12" @default.
- W2012101044 title "Hypoglycemic seizures during transient hypoglycemia exacerbate hippocampal dysfunction" @default.
- W2012101044 cites W128221721 @default.
- W2012101044 cites W1554485658 @default.
- W2012101044 cites W1628349667 @default.
- W2012101044 cites W1917708460 @default.
- W2012101044 cites W1928529925 @default.
- W2012101044 cites W1932953606 @default.
- W2012101044 cites W1965429742 @default.
- W2012101044 cites W1966593755 @default.
- W2012101044 cites W1967823843 @default.
- W2012101044 cites W1968076135 @default.
- W2012101044 cites W1974527546 @default.
- W2012101044 cites W1976091616 @default.
- W2012101044 cites W1979406476 @default.
- W2012101044 cites W1980591991 @default.
- W2012101044 cites W1982337029 @default.
- W2012101044 cites W1984475423 @default.
- W2012101044 cites W1985992749 @default.
- W2012101044 cites W1989700367 @default.
- W2012101044 cites W1990079576 @default.
- W2012101044 cites W1993878094 @default.
- W2012101044 cites W1994983905 @default.
- W2012101044 cites W1996700357 @default.
- W2012101044 cites W1997788251 @default.
- W2012101044 cites W1998164097 @default.
- W2012101044 cites W1998242728 @default.
- W2012101044 cites W1998886336 @default.
- W2012101044 cites W2001043195 @default.
- W2012101044 cites W2001844095 @default.
- W2012101044 cites W2002133823 @default.
- W2012101044 cites W2002433566 @default.
- W2012101044 cites W2005258558 @default.
- W2012101044 cites W2008496662 @default.
- W2012101044 cites W2016517961 @default.
- W2012101044 cites W2019417270 @default.
- W2012101044 cites W2020463662 @default.
- W2012101044 cites W2022923311 @default.
- W2012101044 cites W2024936320 @default.
- W2012101044 cites W2026725369 @default.
- W2012101044 cites W2026747842 @default.
- W2012101044 cites W2027724012 @default.
- W2012101044 cites W2028274352 @default.
- W2012101044 cites W2031387105 @default.
- W2012101044 cites W2032656566 @default.
- W2012101044 cites W2033005983 @default.
- W2012101044 cites W2034004233 @default.
- W2012101044 cites W2036074343 @default.
- W2012101044 cites W2040545929 @default.
- W2012101044 cites W2045147785 @default.
- W2012101044 cites W2045177497 @default.
- W2012101044 cites W2046152621 @default.
- W2012101044 cites W2046721567 @default.
- W2012101044 cites W2047060085 @default.
- W2012101044 cites W2047456559 @default.
- W2012101044 cites W2048305557 @default.
- W2012101044 cites W2048763222 @default.
- W2012101044 cites W2050530837 @default.
- W2012101044 cites W2051798963 @default.
- W2012101044 cites W2052085932 @default.
- W2012101044 cites W2055593737 @default.
- W2012101044 cites W2059469314 @default.
- W2012101044 cites W2065225601 @default.
- W2012101044 cites W2065491054 @default.
- W2012101044 cites W2065720880 @default.
- W2012101044 cites W2067805613 @default.
- W2012101044 cites W2071211769 @default.
- W2012101044 cites W2078156409 @default.
- W2012101044 cites W2080629022 @default.
- W2012101044 cites W2081982894 @default.
- W2012101044 cites W2086201954 @default.
- W2012101044 cites W2089257320 @default.
- W2012101044 cites W2091852171 @default.
- W2012101044 cites W2092635505 @default.
- W2012101044 cites W2093335803 @default.
- W2012101044 cites W2094242565 @default.
- W2012101044 cites W2094641597 @default.
- W2012101044 cites W2097759140 @default.
- W2012101044 cites W2102514021 @default.
- W2012101044 cites W2104938317 @default.
- W2012101044 cites W2105077078 @default.
- W2012101044 cites W2107080306 @default.
- W2012101044 cites W2112457470 @default.
- W2012101044 cites W2113792847 @default.
- W2012101044 cites W2115207803 @default.
- W2012101044 cites W2120336502 @default.