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- W2012103984 abstract "Shortly after the discovery of pressor activity in extracts of the posterior lobe of the pituitary gland (Oliver & Schafer 1895; Howell 1898) it was found that the addition of salt precipitated the active material (Osborne & Vincent 1900). Dale (1906) demonstrated the presence of the oxytocic principle in similar extracts. This activity was later found to accompany the pressor activity in salt precipitates (Kamm et al . 1928). Some years later van Dyke and his co-workers purified the material isolated from fresh pituitary tissue by salt precipitation. It was found to be a protein with a molecular weight of approximately 30 000, that appeared to be homogeneous by physico-chemical criteria. The protein possessed oxytocic, pressor and antidiuretic activities in the same ratios as they occur in the intact bovine pituitary gland (van Dyke, Chow, Greep & Rothen 1942). At that time, this protein was considered to be the natural form of a hormone possessing oxytocic, pressor and antidiuretic activities. However, another view, first expressed by Dudley (1919), suggested that the activities were attributable to the presence of two separate polypeptides. Kamm et al . (1928) extended the work of Dudley and by solvent extraction isolated two active principles, pitocin and pitressin, with molecular weights less than 1000. The classical work of du Vigneaud showed that the pituitary posterior lobe owes its characteristic biological activities to the presence of the polypeptide hormones, oxytocin and vasopressin (du Vigneaud 1955). The relation between the hormones and the so-called van Dyke protein was elucidated in Fromageot's laboratory. It was found that in mild acid oxytocin and vasopressin were dissociated from an inactive protein, neurophysin (Acher, Chauvet & Olivry 1956; Acher & Fromageot 1957. ) The portein-hormone complex could be reconstituted from the components in neutal solution." @default.
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- W2012103984 date "1968-05-14" @default.
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- W2012103984 title "Crystallization of complexes of neurophysins with vasopressin and oxytocin" @default.
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- W2012103984 doi "https://doi.org/10.1098/rspb.1968.0022" @default.
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