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- W2012104034 abstract "Liver/kidney microsome autoantibodies are detectable in different forms of chronic hepatitis, namely autoimmune, viral, and drug-induced hepatitis and in hepatitis associated with Type 1 autoimmune polyglandular syndrome. Based on the aetiology of chronic hepatitis, liver/kidney microsome autoantibodies are directed against different enzymes with very little overlap. Thus, the simple Indirect Immunofluorescence test, which is universally used as a screening test to detect autoantibodies, does not allow subtyping of liver/kidney microsome autoantibodies. This brief review stresses the need to use methods such as Western-Blotting and enzyme-linked immunosorbent assay together with Indirect Immunofluorescence to characterize the liver/kidney microsome autoantibodies. Identification of the liver/kidney microsome target antigens, when possible, makes differential diagnosis easier and, at times, may help the clinician to choose the best approach to treatment." @default.
- W2012104034 created "2016-06-24" @default.
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- W2012104034 date "2000-01-01" @default.
- W2012104034 modified "2023-10-17" @default.
- W2012104034 title "Autoantigen characterization in liver/kidney microsome positive hepatitis" @default.
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- W2012104034 doi "https://doi.org/10.1016/s1590-8658(00)80043-2" @default.
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