Matches in SemOpenAlex for { <https://semopenalex.org/work/W2012105483> ?p ?o ?g. }
- W2012105483 endingPage "1291" @default.
- W2012105483 startingPage "1280" @default.
- W2012105483 abstract "The receptor for activated C-kinase (RACK1), a scaffolding protein that participates in the protein kinase C (PKC) signaling pathway, has an important role in shuttling active PKCs to its substrate. Indeed, recent studies have revealed that RACK1 has an important role in tumorigenesis and that enhancement of the feed-forward mechanism of the c-Jun N-terminal kinase (JNK)–Jun pathway via RACK1 is associated with constitutive activation of MEK (MAPK-ERK kinase)–ERK (extracellular signal-regulated kinase) signaling in human melanoma cells. Taken together, RACK1 additionally has a very important role in the mitogen-activated protein kinase (MAPK) signaling pathway. Here, we show that one of the tripartite motif-containing (TRIM) family ubiquitin ligases, TRIM45, is a novel RACK1-interacting protein and downregulates MAPK signal transduction. Importantly, the expression of TRIM45 is induced when growth-promoting extracellular stimuli activate the MAPK signaling pathway, resulting in attenuation of activation of the MAPK pathway. These findings suggest that TRIM45 functions as a member of the negative feedback loop of the MAPK pathway." @default.
- W2012105483 created "2016-06-24" @default.
- W2012105483 creator A5026368397 @default.
- W2012105483 creator A5026840406 @default.
- W2012105483 creator A5032163283 @default.
- W2012105483 creator A5045899068 @default.
- W2012105483 creator A5068374303 @default.
- W2012105483 date "2014-03-31" @default.
- W2012105483 modified "2023-10-18" @default.
- W2012105483 title "The TRIM-FLMN protein TRIM45 directly interacts with RACK1 and negatively regulates PKC-mediated signaling pathway" @default.
- W2012105483 cites W1980991018 @default.
- W2012105483 cites W1983687466 @default.
- W2012105483 cites W1984901090 @default.
- W2012105483 cites W1989039704 @default.
- W2012105483 cites W1993793397 @default.
- W2012105483 cites W1994758600 @default.
- W2012105483 cites W1997917368 @default.
- W2012105483 cites W1998809668 @default.
- W2012105483 cites W1999597976 @default.
- W2012105483 cites W2002039213 @default.
- W2012105483 cites W2018078080 @default.
- W2012105483 cites W2022802363 @default.
- W2012105483 cites W2023972740 @default.
- W2012105483 cites W2029352353 @default.
- W2012105483 cites W2031962092 @default.
- W2012105483 cites W2034134605 @default.
- W2012105483 cites W2034375388 @default.
- W2012105483 cites W2043532819 @default.
- W2012105483 cites W2048140226 @default.
- W2012105483 cites W2049904360 @default.
- W2012105483 cites W2059411210 @default.
- W2012105483 cites W2064222837 @default.
- W2012105483 cites W2066509081 @default.
- W2012105483 cites W2074767062 @default.
- W2012105483 cites W2078481163 @default.
- W2012105483 cites W2079216025 @default.
- W2012105483 cites W2088947549 @default.
- W2012105483 cites W2090471661 @default.
- W2012105483 cites W2100712519 @default.
- W2012105483 cites W2107495112 @default.
- W2012105483 cites W2116189372 @default.
- W2012105483 cites W2116773729 @default.
- W2012105483 cites W2122057254 @default.
- W2012105483 cites W2123626707 @default.
- W2012105483 cites W2129029860 @default.
- W2012105483 cites W2131037087 @default.
- W2012105483 cites W2136701323 @default.
- W2012105483 cites W2138696503 @default.
- W2012105483 cites W2140001006 @default.
- W2012105483 cites W2140017673 @default.
- W2012105483 cites W2144099695 @default.
- W2012105483 cites W2155584359 @default.
- W2012105483 cites W2160332942 @default.
- W2012105483 cites W2161696777 @default.
- W2012105483 cites W2162434450 @default.
- W2012105483 cites W2310610289 @default.
- W2012105483 cites W4211258630 @default.
- W2012105483 cites W4385110469 @default.
- W2012105483 doi "https://doi.org/10.1038/onc.2014.68" @default.
- W2012105483 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24681954" @default.
- W2012105483 hasPublicationYear "2014" @default.
- W2012105483 type Work @default.
- W2012105483 sameAs 2012105483 @default.
- W2012105483 citedByCount "27" @default.
- W2012105483 countsByYear W20121054832014 @default.
- W2012105483 countsByYear W20121054832016 @default.
- W2012105483 countsByYear W20121054832017 @default.
- W2012105483 countsByYear W20121054832018 @default.
- W2012105483 countsByYear W20121054832019 @default.
- W2012105483 countsByYear W20121054832020 @default.
- W2012105483 countsByYear W20121054832021 @default.
- W2012105483 countsByYear W20121054832022 @default.
- W2012105483 countsByYear W20121054832023 @default.
- W2012105483 crossrefType "journal-article" @default.
- W2012105483 hasAuthorship W2012105483A5026368397 @default.
- W2012105483 hasAuthorship W2012105483A5026840406 @default.
- W2012105483 hasAuthorship W2012105483A5032163283 @default.
- W2012105483 hasAuthorship W2012105483A5045899068 @default.
- W2012105483 hasAuthorship W2012105483A5068374303 @default.
- W2012105483 hasBestOaLocation W20121054831 @default.
- W2012105483 hasConcept C124160383 @default.
- W2012105483 hasConcept C137361374 @default.
- W2012105483 hasConcept C184235292 @default.
- W2012105483 hasConcept C195794163 @default.
- W2012105483 hasConcept C2909504400 @default.
- W2012105483 hasConcept C53645450 @default.
- W2012105483 hasConcept C57074206 @default.
- W2012105483 hasConcept C62478195 @default.
- W2012105483 hasConcept C86803240 @default.
- W2012105483 hasConcept C90934575 @default.
- W2012105483 hasConcept C95444343 @default.
- W2012105483 hasConcept C97029542 @default.
- W2012105483 hasConcept C99405784 @default.
- W2012105483 hasConceptScore W2012105483C124160383 @default.
- W2012105483 hasConceptScore W2012105483C137361374 @default.
- W2012105483 hasConceptScore W2012105483C184235292 @default.
- W2012105483 hasConceptScore W2012105483C195794163 @default.
- W2012105483 hasConceptScore W2012105483C2909504400 @default.